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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  先天免疫系统通过Toll样受体(TLR),其识别病原体相关的分子模式识别微生物病原体。不同的TLR识别不同病原体相关分子模式,所有的TLR具有电话-白细胞介素1受体(TIR)结构域,其负责信号转导。由该基因编码的蛋白质是一种参与免疫系统的TLR4信号传导途径一项TIR衔接蛋白。它激活的NF-κ-B,MAPK1,MAPK3和JNK,然后导致细胞因子分泌和炎症反应。在几个转录变异体本基因的结果的选择性剪接;然而,并非所有的变体已被充分地描述。 [由RefSeq的,2008年7月提供]
TIRAP基因(以及对应的蛋白质)的细胞分布位置:
TIRAP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Tuberculosis | 0.135731154 | 8 | 0 | BeFree_CTD_human_GAD_LHGDN |
Malaria | 0.120814326 | 4 | 2 | BeFree_CTD_human |
Bacteremia | 0.12 | 1 | 0 | CTD_human |
Pneumococcal Infections | 0.12 | 1 | 0 | CTD_human |
Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) | 0.12 | 0 | 0 | CTD_human |
Invasive Pneumococcal Disease, Recurrent Isolated, 1 | 0.12 | 0 | 0 | CTD_human |
Tuberculosis, Pulmonary | 0.00554839 | 5 | 2 | BeFree_GAD |
Sepsis | 0.00554839 | 3 | 0 | BeFree_GAD |
Lupus Erythematosus, Systemic | 0.005091382 | 1 | 0 | GAD_LHGDN |
Malignant neoplasm of prostate | 0.004734064 | 2 | 0 | GAD |
HIV Infections | 0.004267125 | 7 | 1 | BeFree_GAD |
Inflammatory Bowel Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Tuberculosis, Meningeal | 0.002909916 | 3 | 0 | BeFree_GAD |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Chagas Cardiomyopathy | 0.002638474 | 1 | 2 | BeFree_GAD |
Bacteriuria | 0.002367032 | 1 | 0 | GAD |
Oral candidiasis | 0.002367032 | 1 | 0 | GAD |
Cross Infection | 0.002367032 | 1 | 0 | GAD |
Cystitis | 0.002367032 | 1 | 0 | GAD |
Dermatitis, Atopic | 0.002367032 | 1 | 0 | GAD |
Malaria, Falciparum | 0.002367032 | 1 | 0 | GAD |
Pyelonephritis | 0.002367032 | 1 | 0 | GAD |
Respiratory Distress Syndrome, Adult | 0.002367032 | 1 | 0 | GAD |
Urinary tract infection | 0.002367032 | 1 | 0 | GAD |
Acute Lung Injury | 0.002367032 | 1 | 0 | GAD |
Pneumonia, Ventilator-Associated | 0.002367032 | 1 | 0 | GAD |
Acute Megakaryocytic Leukemias | 0.001357209 | 5 | 0 | BeFree |
Mediastinal (Thymic) Large B-Cell Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of cervix | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Septicemia | 0.000814326 | 3 | 0 | BeFree |
Pelvic Inflammatory Disease | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Rheumatoid Arthritis | 0.000542884 | 2 | 3 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Down Syndrome | 0.000542884 | 2 | 0 | BeFree |
Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
Esophageal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cervix carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cervical intraepithelial neoplasia grade 2 | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Cervix Diseases | 0.000271442 | 1 | 0 | BeFree |
Dengue Fever | 0.000271442 | 1 | 0 | BeFree |
Dental caries | 0.000271442 | 1 | 0 | BeFree |
Heavy Chain Disease | 0.000271442 | 1 | 0 | BeFree |
Severe Dengue | 0.000271442 | 1 | 0 | BeFree |
Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
Keloid | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Trisomy | 0.000271442 | 1 | 0 | BeFree |
Chagas Disease | 0.000271442 | 1 | 2 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic bacteriuria | 0.000271442 | 1 | 0 | BeFree |
Clinical infection | 0.000271442 | 1 | 0 | BeFree |
Chronic Chagas' disease | 0.000271442 | 1 | 2 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
Plasmodium ovale infection | 0.000271442 | 1 | 0 | BeFree |
Candidemia | 0.000271442 | 1 | 0 | BeFree |
Oropharyngeal candidiasis | 0.000271442 | 1 | 1 | BeFree |
Spondylarthritis | 0.000271442 | 1 | 2 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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