TIRAP(toll-interleukin 1 receptor (TIR) domain containing adaptor protein)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

11q24.2
基因染色体位置图

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  先天免疫系统通过Toll样受体(TLR),其识别病原体相关的分子模式识别微生物病原体。不同的TLR识别不同病原体相关分子模式,所有的TLR具有电话-白细胞介素1受体(TIR)结构域,其负责信号转导。由该基因编码的蛋白质是一种参与免疫系统的TLR4信号传导途径一项TIR衔接蛋白。它激活的NF-κ-B,MAPK1,MAPK3和JNK,然后导致细胞因子分泌和炎症反应。在几个转录变异体本基因的结果的选择性剪接;然而,并非所有的变体已被充分地描述。 [由RefSeq的,2008年7月提供]

TIRAP基因的碱基序列:[NCBI]
TIRAP基因的碱基突变:           显示全部snp
rs625413       rs4937115       rs8177378       rs34539128       rs73631789       rs77356646       rs79200087       rs112753441       rs117322993       rs145593047       rs148820042       rs149692387       rs181355081       rs190111292       rs201653471       rs529830154       rs530081831       rs530190298       rs530685619       rs531050488       rs536757576       rs538912520       rs539281854       rs544909573       rs546971518       rs551011407       rs552918325       rs553350842       rs556047977       rs556678042       rs558746241       rs559435483       rs561417205       rs565039182       rs565078424       rs567675929       rs570314235      
rs571798168       rs573069784       rs573259758       rs573676322       rs577332159       rs748112219       rs749423410       rs749834825       rs753166870       rs754851889       rs755942046       rs758129283       rs761001194       rs764815245       rs765928079       rs771113382       rs772382266       rs775655543       rs777153653       rs93957       rs563011       rs595022       rs595209       rs609634       rs611953       rs614700       rs646005       rs655540       rs671492       rs904546       rs1392060       rs1786697       rs1893352       rs3017014       rs3802813       rs3802814       rs4935964       rs4937114       rs7119265       rs7932766       rs7932976       rs8177340       rs8177341       rs8177342       rs8177343       rs8177344       rs8177345       rs8177346       rs8177347       rs8177348       rs8177349       rs8177350       rs8177351       rs8177352       rs8177353       rs8177354       rs8177355       rs8177356       rs8177357       rs8177358       rs8177359       rs8177360       rs8177361       rs8177362       rs8177364       rs8177365       rs8177366       rs8177367       rs8177368       rs8177369       rs8177371       rs8177372       rs8177373       rs8177374       rs8177375       rs8177376       rs8177377       rs8177396       rs8177397       rs8177398       rs8177399       rs8177400       rs10893493       rs11220440       rs34033281       rs35140212       rs58227470       rs58280127       rs59512602       rs60039687       rs71048778       rs71475948       rs73017367       rs73631779       rs73631781       rs74365595       rs74937157       rs75454257       rs75531260       rs75555088       rs76065102       rs77061488       rs78208328       rs78925792       rs79913367       rs79946960       rs111271231       rs111449740       rs111632926       rs111690127       rs112081523       rs112311849       rs112423831       rs113042259       rs113712604       rs116496943       rs117167403       rs117176605       rs117512949       rs138228187       rs138477220       rs138656252       rs139098112       rs139545965       rs140419050       rs140585265       rs140720235       rs141036053       rs141277221       rs141375375       rs141732221       rs141779289       rs141792148       rs141988661       rs142475083       rs142819483       rs143034071       rs143347154       rs143770995       rs143817644       rs144124211       rs144258412       rs145158457       rs145234436       rs145551980       rs145569484       rs145991466       rs146328813       rs146531774       rs146931609       rs146954493       rs147530219       rs147593820       rs147709707       rs147917451       rs147940572       rs148181935       rs148618551       rs148671043       rs148714582       rs149049403       rs149490135       rs149850632       rs149892282       rs150070873       rs150079666       rs150121675       rs150763317       rs151025684       rs180718376       rs181037127       rs181553923       rs181704739       rs181981276       rs182105045       rs183126753       rs183249132       rs183336403       rs183881679       rs184071676       rs184255980       rs184268617       rs184774567       rs185062387       rs185114125       rs186025443       rs186149435       rs186179301       rs186287734       rs186766660       rs186799814       rs187454335       rs187568807       rs187945091       rs188147665       rs188398729       rs188687753       rs188749225       rs189099942       rs189466471       rs189470404       rs189556826       rs189610165       rs190295653       rs190517969       rs190659583       rs191103683       rs191200631       rs191752210       rs192136400       rs192294692       rs192440178       rs192734323       rs192770230       rs199545047       rs199561634       rs199660307       rs199835227       rs199917692       rs199998834       rs200001768       rs200346561       rs200394933       rs200442139       rs200601992       rs200632029       rs200902905       rs201377080       rs201438432       rs201470535       rs201689745       rs202146623       rs202228775       rs367776674       rs367981684       rs368163253       rs368360725       rs368658841       rs368918609       rs369062013       rs370087661       rs370165397       rs370327778       rs370415672       rs370902644       rs371062583       rs371238382       rs371258734       rs371475856       rs372040321       rs372137090       rs372725192       rs372803124       rs373668992       rs373866119       rs374470306       rs374738895       rs374746831       rs375840989       rs375992020       rs376255622       rs376275326       rs376494593       rs376608885       rs377122587       rs377193452       rs377412443       rs397820022       rs398045713       rs527324282       rs527374521       rs527632744       rs528033961       rs528352426       rs528383769       rs528400653       rs528650257       rs528977303       rs529015796       rs529133625       rs529445226       rs529468179       rs529663797       rs529873587       rs530012627       rs530714717       rs530833545       rs531086680       rs531455918       rs531716431       rs531750429       rs531831552       rs532296481       rs532438907       rs532577631       rs532665736       rs532728808       rs532885851       rs533434228       rs533471383       rs533613663       rs533653624       rs534165298       rs534579716       rs534793953       rs534859363       rs534965018       rs535306914       rs535310174       rs536327305       rs536688502       rs536724633       rs537135497       rs537172529       rs537212025       rs537565465       rs537808222       rs537883742       rs538051685       rs538097011       rs538133863       rs538145206       rs538550141       rs538949337       rs539074838       rs539320450       rs539337534       rs539607549       rs540498904       rs540780734       rs541054649       rs541133540       rs541439959       rs541850843       rs541889790       rs542279259       rs542279352       rs542284217       rs542315970       rs543051018       rs543232963       rs543271785       rs543510485       rs543844957       rs543916727       rs544062433       rs544099152       rs544487120       rs544499191       rs544727620       rs545179533       rs545701610       rs545738437       rs546285736       rs547066847       rs547076029       rs547657084       rs547712649       rs548169969       rs548257923       rs548259823       rs548594347       rs548742559       rs548764091       rs548815192       rs549504346       rs549615868       rs549777408       rs550102318       rs550141015       rs550780348       rs551426825       rs552322718       rs552359208       rs552572066       rs552753664       rs553438497       rs553477239       rs553666219       rs553913263       rs553945339       rs554581765       rs554719830       rs554756421       rs554916634       rs555155716       rs555918042       rs556103037       rs556376399       rs556387047       rs556713393       rs557049744       rs557664107       rs557850258       rs558190491       rs558676904       rs558907545       rs558942736       rs558942850       rs559126856       rs559253556       rs559269340       rs559338971       rs559677379       rs560408899       rs560550120       rs561051130       rs561160232       rs561369239       rs561733312       rs562683866       rs562684565       rs562937250       rs562945557       rs563269513       rs563437358       rs563836979       rs564049159       rs564069013       rs564343089       rs564530372       rs564844467       rs564912785       rs565074002       rs565217335       rs565319069       rs565508190       rs565706730       rs566475661       rs566722631       rs566866099       rs567078924       rs567333611       rs567673899       rs567797528       rs567808997       rs568070666       rs568101960       rs568284829       rs568886214       rs569120191       rs569197366       rs569235623       rs569274207       rs570197170       rs570715394       rs570847444       rs570852178       rs571397965       rs571494023       rs571561466       rs571740027       rs571759537       rs572123088       rs572239664       rs572360033       rs572886105       rs573241018       rs573312624       rs573398675       rs573435423       rs573607343       rs573609407       rs573968662       rs574055018       rs574384452       rs574454880       rs574703369       rs575103598       rs575206160       rs575485656       rs575836905       rs575921771       rs576124949       rs576166186       rs576655628       rs577919796       rs578026713       rs745657996       rs745690141       rs745973224       rs746387179       rs746511505       rs746556658       rs746590765       rs746808811       rs746978648       rs747051110       rs747158943       rs747376430       rs747533881       rs747655758       rs747681363       rs748062933       rs748133187       rs748387019       rs748624875       rs748844777       rs748902355       rs748951042       rs749603061       rs749705411       rs749865186       rs749987518       rs749999955       rs750111581       rs750153440       rs750353344       rs750457025       rs750571122       rs750704073       rs751251348       rs751865534       rs751919028       rs752935097       rs753041693       rs753059647       rs753272873       rs753280935       rs753885211       rs754008409       rs754139124       rs754373958       rs754727557       rs754830044       rs755014520       rs755084660       rs755202575       rs755654831       rs755778574       rs756158088       rs756386841       rs756548291       rs756558444       rs756647617       rs756728303       rs756734619       rs757282543       rs757439874       rs757708701       rs757872440       rs757898151       rs757928686       rs758051128       rs758594472       rs758642937       rs758763451       rs758804211       rs758948205       rs759310955       rs759467034       rs759472481       rs759677196       rs759918323       rs759995906       rs760487756       rs760961688       rs761236017       rs761479944       rs761805889       rs761929898       rs762150180       rs762717757       rs763103589       rs763105480       rs763113795       rs763335757       rs763520934       rs764022736       rs764091270       rs764540927       rs764568258       rs764570431       rs764955992       rs765257391       rs765726820       rs765775900       rs765930909       rs766347245       rs766588692       rs766698588       rs766752020       rs766778509       rs766792026       rs767266208       rs767316936       rs767436996       rs767725127       rs768403294       rs768526790       rs768530403       rs768797256       rs769482991       rs769912545       rs769940334       rs770014584       rs770169710       rs770438419       rs770500774       rs770504972       rs770625492       rs770737775       rs771069753       rs771228866       rs771322089       rs771651612       rs771728710       rs771932352       rs771952286       rs772224671       rs772729225       rs772763353       rs772823681       rs773053552       rs773226287       rs773281763       rs773371263       rs773396251       rs773485764       rs773742868       rs774196466       rs774514307       rs774640801       rs775082196       rs775149300       rs775206937       rs775382891       rs775748248       rs775978982       rs776604499       rs776649284       rs776805808       rs777219128       rs777669984       rs777871896       rs778246345       rs778328776       rs778354163       rs778602443       rs778742734       rs779284482       rs779664279       rs780524458       rs780635079       rs780683842       rs780780502       rs781088797       rs781244646       rs781258150       rs781581574       rs781760006       rs869220658       rs869257544      

TIRAP基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
ATGTACTACGTCGATGGCA
59
GAGTGTCTGCAGATAACGC
59
GATTCATGTACTACGTCGATGG
59
TCTGCAGATAACGCATGAC
58
AGATGGCTGACTGGTTCAG
59
ACTACTGCCACTGTCACTC
59
TAGGCAAGATGGCTGACTG
60
GTGTCAGGTATGTCAGGGAG
60
AGATGGCTGACTGGTTCAG
59
GAGACGTGACTGAGCTGAG
59
AGAACATGGCCTTACATAGGA
58
AACTGTTCTCTGCTCCACC
59
ATGTACTACGTCGATGGCA
59
GAGTGTCTGCAGATAACGC
59
TAGGCAAGATGGCTGACTG
59
GAGACGTGACTGAGCTGAG
59
CATGTACTACGTCGATGGC
58
GAGTGTCTGCAGATAACGC
59
GATTCATGTACTACGTCGATGG
59
TCTGCAGATAACGCATGAC
58
      尚未收录相关数据

TIRAP基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TIRAP基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0002755
P58753(UniProtKB)
TAS
GO:0002755
P58753(UniProtKB)
TAS
GO:0005080
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005515
P58753(UniProtKB)
IPI
GO:0005546
P58753(UniProtKB)
ISS
GO:0005654
P58753(UniProtKB)
IDA
GO:0005737
P58753(UniProtKB)
IDA
GO:0005737
P58753(UniProtKB)
IDA
GO:0005829
P58753(UniProtKB)
TAS
GO:0005829
P58753(UniProtKB)
TAS
GO:0005829
P58753(UniProtKB)
TAS
GO:0005829
P58753(UniProtKB)
TAS
GO:0005829
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
IDA
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0005886
P58753(UniProtKB)
TAS
GO:0006954
P58753(UniProtKB)
IEA
GO:0007166
P58753(UniProtKB)
ISS
GO:0030099
P58753(UniProtKB)
ISS
GO:0030139
P58753(UniProtKB)
ISS
GO:0030674
P58753(UniProtKB)
NAS
GO:0030890
P58753(UniProtKB)
ISS
GO:0032496
P58753(UniProtKB)
IDA
GO:0032587
P58753(UniProtKB)
ISS
GO:0032648
P58753(UniProtKB)
ISS
GO:0032735
P58753(UniProtKB)
ISS
GO:0032738
P58753(UniProtKB)
IDA
GO:0032757
P58753(UniProtKB)
IMP
GO:0032760
P58753(UniProtKB)
IMP
GO:0032760
P58753(UniProtKB)
IMP
GO:0034137
P58753(UniProtKB)
IMP
GO:0034141
P58753(UniProtKB)
ISS
GO:0034142
P58753(UniProtKB)
TAS
GO:0034145
P58753(UniProtKB)
IMP
GO:0035662
P58753(UniProtKB)
IPI
GO:0035663
P58753(UniProtKB)
IPI
GO:0035665
P58753(UniProtKB)
IDA
GO:0042803
P58753(UniProtKB)
ISS
GO:0043123
P58753(UniProtKB)
IMP
GO:0044130
P58753(UniProtKB)
ISS
GO:0045087
P58753(UniProtKB)
IEA
GO:0045088
P58753(UniProtKB)
IC
GO:0045171
P58753(UniProtKB)
IDA
GO:0045410
P58753(UniProtKB)
IMP
GO:0046330
P58753(UniProtKB)
IMP
GO:0046982
P58753(UniProtKB)
IDA
GO:0050830
P58753(UniProtKB)
ISS
GO:0051092
P58753(UniProtKB)
IMP
GO:0070374
P58753(UniProtKB)
IMP
GO:0070935
P58753(UniProtKB)
IDA
GO:0071221
P58753(UniProtKB)
ISS
GO:0071223
P58753(UniProtKB)
ISS
GO:0090023
P58753(UniProtKB)
ISS
GO:0090073
P58753(UniProtKB)
IDA
GO:2000340
P58753(UniProtKB)
ISS
GO:2000343
P58753(UniProtKB)
ISS
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控TIRAP基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Tuberculosis 0.135731154 8 0 BeFree_CTD_human_GAD_LHGDN
Malaria 0.120814326 4 2 BeFree_CTD_human
Bacteremia 0.12 1 0 CTD_human
Pneumococcal Infections 0.12 1 0 CTD_human
Prostatic Neoplasms 0.12 1 0 CTD_human
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO (finding) 0.12 0 0 CTD_human
Invasive Pneumococcal Disease, Recurrent Isolated, 1 0.12 0 0 CTD_human
Tuberculosis, Pulmonary 0.00554839 5 2 BeFree_GAD
Sepsis 0.00554839 3 0 BeFree_GAD
Lupus Erythematosus, Systemic 0.005091382 1 0 GAD_LHGDN
Malignant neoplasm of prostate 0.004734064 2 0 GAD
HIV Infections 0.004267125 7 1 BeFree_GAD
Inflammatory Bowel Diseases 0.002995792 1 0 BeFree_LHGDN
Tuberculosis, Meningeal 0.002909916 3 0 BeFree_GAD
Infection 0.00272435 1 0 LHGDN
Chagas Cardiomyopathy 0.002638474 1 2 BeFree_GAD
Bacteriuria 0.002367032 1 0 GAD
Oral candidiasis 0.002367032 1 0 GAD
Cross Infection 0.002367032 1 0 GAD
Cystitis 0.002367032 1 0 GAD
Dermatitis, Atopic 0.002367032 1 0 GAD
Malaria, Falciparum 0.002367032 1 0 GAD
Pyelonephritis 0.002367032 1 0 GAD
Respiratory Distress Syndrome, Adult 0.002367032 1 0 GAD
Urinary tract infection 0.002367032 1 0 GAD
Acute Lung Injury 0.002367032 1 0 GAD
Pneumonia, Ventilator-Associated 0.002367032 1 0 GAD
Acute Megakaryocytic Leukemias 0.001357209 5 0 BeFree
Mediastinal (Thymic) Large B-Cell Lymphoma 0.001085767 4 0 BeFree
Malignant neoplasm of breast 0.000814326 3 0 BeFree
Malignant tumor of cervix 0.000814326 3 0 BeFree
Leukemia, Myelocytic, Acute 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Septicemia 0.000814326 3 0 BeFree
Pelvic Inflammatory Disease 0.000814326 3 0 BeFree
Breast Carcinoma 0.000814326 3 0 BeFree
Stomach Carcinoma 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Rheumatoid Arthritis 0.000542884 2 3 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Down Syndrome 0.000542884 2 0 BeFree
Esophageal Neoplasms 0.000542884 2 0 BeFree
Liver neoplasms 0.000542884 2 0 BeFree
Esophageal carcinoma 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Cervical intraepithelial neoplasia grade 2 0.000542884 2 0 BeFree
Malignant neoplasm of esophagus 0.000542884 2 0 BeFree
Squamous cell carcinoma of the head and neck 0.000542884 2 0 BeFree
Bacterial Infections 0.000271442 1 0 BeFree
Cervix Diseases 0.000271442 1 0 BeFree
Dengue Fever 0.000271442 1 0 BeFree
Dental caries 0.000271442 1 0 BeFree
Heavy Chain Disease 0.000271442 1 0 BeFree
Severe Dengue 0.000271442 1 0 BeFree
Hodgkin Disease 0.000271442 1 0 BeFree
Keloid 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pneumonia 0.000271442 1 0 BeFree
Trisomy 0.000271442 1 0 BeFree
Chagas Disease 0.000271442 1 2 BeFree
Virus Diseases 0.000271442 1 0 BeFree
Asymptomatic bacteriuria 0.000271442 1 0 BeFree
Clinical infection 0.000271442 1 0 BeFree
Chronic Chagas' disease 0.000271442 1 2 BeFree
Leukemogenesis 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Malignant neoplasm of gastrointestinal tract 0.000271442 1 0 BeFree
Plasmodium ovale infection 0.000271442 1 0 BeFree
Candidemia 0.000271442 1 0 BeFree
Oropharyngeal candidiasis 0.000271442 1 1 BeFree
Spondylarthritis 0.000271442 1 2 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Classical Hodgkin's Lymphoma 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
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