更多...
收起
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是用于甲状腺素核激素受体。它是几个受体甲状腺激素之一,并且已经显示出介导甲状腺激素的生物活性。在小鼠中敲除的研究表明,在不同的受体,而具有冗余的一定程度时,可以介导的甲状腺激素不同的功能。已经报道了编码不同同种型的可变剪接转录物变体。 [由RefSeq的,2008年7月提供]
THRA基因(以及对应的蛋白质)的细胞分布位置:
THRA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 6 | 0.24 | 2 | 2 | CLINVAR_UNIPROT |
Endometriosis | 0.12 | 1 | 0 | CTD_human |
Diaphragmatic Hernia | 0.12 | 1 | 0 | CTD_human |
Left Ventricular Hypertrophy | 0.08 | 1 | 0 | RGD |
Alzheimer's Disease | 0.007101096 | 3 | 0 | GAD |
Thyroid Neoplasm | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Thyroid carcinoma | 0.003724241 | 5 | 0 | BeFree_GAD |
Liver carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Adenoma | 0.00272435 | 1 | 0 | LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Degenerative polyarthritis | 0.002638474 | 1 | 0 | BeFree_GAD |
Malignant neoplasm of thyroid | 0.001085767 | 4 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Neurofibromatosis 1 | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Hypothyroidism | 0.000542884 | 2 | 0 | BeFree |
Erythroblastosis | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Thyroid Hormone Resistance Syndrome | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Constipation | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Dwarfism | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 1 | BeFree |
Acute Erythroblastic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Macrocephaly | 0.000271442 | 1 | 0 | BeFree |
Liver mass | 0.000271442 | 1 | 0 | BeFree |
Benign neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Skeletal dysplasia | 0.000271442 | 1 | 0 | BeFree |
Van Buchem disease | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。