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The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个二硫键连接的同源三聚体蛋白质的一个亚单位。这种蛋白质是粘合剂的糖蛋白介导细胞 - 细胞和细胞 - 基质相互作用。这种蛋白质可以结合到纤维蛋白原,纤连蛋白,层粘连蛋白,V型胶原蛋白和整联的α-V /β-1。这种蛋白已经显示出血小板聚集,血管生成和肿瘤发生中发挥的作用。 [由RefSeq的,2008年7月提供]
THBS1基因(以及对应的蛋白质)的细胞分布位置:
THBS1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetic Retinopathy | 0.2 | 1 | 0 | CTD_human_RGD |
| Mammary Neoplasms | 0.123538676 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Liver Cirrhosis | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Schizophrenia | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Fibrosis | 0.12 | 1 | 0 | CTD_human |
| Nephritis, Interstitial | 0.12 | 1 | 0 | CTD_human |
| Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Myocardial Infarction | 0.094364013 | 11 | 2 | BeFree_GAD_LHGDN_RGD |
| Prostatic Neoplasms | 0.081085767 | 5 | 0 | BeFree_RGD |
| Heart Diseases | 0.080271442 | 2 | 0 | BeFree_RGD |
| Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
| Mammary Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
| Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
| Sjogren's Syndrome | 0.08 | 0 | 0 | MGD |
| Cerebral Hemorrhage | 0.08 | 1 | 0 | RGD |
| Tropical Spastic Paraparesis | 0.013572094 | 50 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.013300652 | 49 | 1 | BeFree |
| Neoplasm Metastasis | 0.011963305 | 25 | 1 | BeFree_LHGDN |
| Inflammation | 0.010897401 | 4 | 0 | LHGDN |
| melanoma | 0.006795978 | 15 | 0 | BeFree_LHGDN |
| Colorectal Cancer | 0.006634157 | 8 | 10 | BeFree_GAD |
| Squamous cell carcinoma | 0.006263026 | 4 | 0 | BeFree_LHGDN |
| Leukemia, T-Cell | 0.006243163 | 23 | 0 | BeFree |
| Diabetic Nephropathy | 0.005991584 | 3 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.005971721 | 22 | 0 | BeFree |
| Breast Carcinoma | 0.005971721 | 22 | 0 | BeFree |
| Colorectal Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Thyroid Neoplasm | 0.0054487 | 2 | 0 | LHGDN |
| Glioma | 0.005438769 | 10 | 0 | BeFree_LHGDN |
| Adenoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Coronary Artery Disease | 0.00408156 | 5 | 1 | BeFree_LHGDN |
| Rheumatoid Arthritis | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Ischemia | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Tumor Progression | 0.003800186 | 14 | 0 | BeFree |
| Coronary Arteriosclerosis | 0.003724241 | 6 | 1 | BeFree_GAD |
| Malignant neoplasm of prostate | 0.003724241 | 5 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Renal Cell Carcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Osteosarcoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.003452799 | 5 | 0 | BeFree_GAD |
| Malignant neoplasm of stomach | 0.003257302 | 12 | 1 | BeFree |
| Carcinogenesis | 0.003257302 | 12 | 0 | BeFree |
| Tumor Angiogenesis | 0.003257302 | 12 | 0 | BeFree |
| Fibroid Tumor | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Stomach Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Inclusion Body Myositis (disorder) | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Dementia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Stomach Carcinoma | 0.002985861 | 11 | 1 | BeFree |
| Anoxia | 0.00272435 | 1 | 0 | LHGDN |
| Fever | 0.00272435 | 1 | 0 | LHGDN |
| Hemorrhagic Fever with Renal Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| keratoacanthoma | 0.00272435 | 1 | 0 | LHGDN |
| Penile Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Synovitis | 0.00272435 | 1 | 0 | LHGDN |
| Epiretinal Membrane | 0.00272435 | 1 | 0 | LHGDN |
| Sarcoma | 0.00272435 | 1 | 0 | LHGDN |
| Cerebrovascular accident | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malignant tumor of colon | 0.002442977 | 9 | 0 | BeFree |
| HTLV-I Infections | 0.002442977 | 9 | 0 | BeFree |
| Pancreatic carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Premature Birth | 0.002367032 | 1 | 0 | GAD |
| Brain hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
| Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Stroke, Lacunar | 0.002367032 | 1 | 0 | GAD |
| nervous system disorder | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.002171535 | 8 | 0 | BeFree |
| Colon Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Carcinoma | 0.001900093 | 7 | 10 | BeFree |
| Obesity | 0.001900093 | 7 | 0 | BeFree |
| Ovarian Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Thyroid carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Human T-cell lymphotropic virus 1 infection | 0.001900093 | 7 | 0 | BeFree |
| Glioblastoma | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.001628651 | 6 | 0 | BeFree |
| Arteriosclerosis | 0.001357209 | 5 | 0 | BeFree |
| Bone Marrow Diseases | 0.001357209 | 5 | 0 | BeFree |
| Coronary heart disease | 0.001357209 | 5 | 1 | BeFree |
| HIV Infections | 0.001357209 | 5 | 2 | BeFree |
| Spinal Cord Diseases | 0.001357209 | 5 | 0 | BeFree |
| Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.001357209 | 5 | 1 | BeFree |
| Inflammatory disorder | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.001085767 | 4 | 0 | BeFree |
| Endometriosis | 0.001085767 | 4 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
| Diabetes | 0.000814326 | 3 | 0 | BeFree |
| Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
| leukemia | 0.000814326 | 3 | 0 | BeFree |
| Multiple Sclerosis | 0.000814326 | 3 | 0 | BeFree |
| Degenerative polyarthritis | 0.000814326 | 3 | 0 | BeFree |
| Virus Diseases | 0.000814326 | 3 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Dermatomyositis, Childhood Type | 0.000814326 | 3 | 0 | BeFree |
| Endometrioma | 0.000814326 | 3 | 0 | BeFree |
| Metastatic melanoma | 0.000814326 | 3 | 0 | BeFree |
| Solid tumour | 0.000814326 | 3 | 0 | BeFree |
| Restenosis | 0.000814326 | 3 | 0 | BeFree |
| Malignant Glioma | 0.000814326 | 3 | 0 | BeFree |
| Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
| Angiogenic Switch | 0.000814326 | 3 | 0 | BeFree |
| Peripheral Arterial Diseases | 0.000814326 | 3 | 0 | BeFree |
| Juvenile dermatomyositis | 0.000814326 | 3 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000542884 | 2 | 0 | BeFree |
| Cardiovascular Diseases | 0.000542884 | 2 | 0 | BeFree |
| Diabetic Angiopathies | 0.000542884 | 2 | 0 | BeFree |
| Glaucoma | 0.000542884 | 2 | 0 | BeFree |
| Heart failure | 0.000542884 | 2 | 0 | BeFree |
| Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
| Helminthiasis | 0.000542884 | 2 | 0 | BeFree |
| Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Liver neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Meningioma | 0.000542884 | 2 | 0 | BeFree |
| Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
| Myopathy | 0.000542884 | 2 | 0 | BeFree |
| Mycoses | 0.000542884 | 2 | 0 | BeFree |
| Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
| Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
| Chronic gastritis | 0.000542884 | 2 | 0 | BeFree |
| Renal fibrosis | 0.000542884 | 2 | 0 | BeFree |
| Idiopathic pulmonary hypertension | 0.000542884 | 2 | 0 | BeFree |
| Uveal melanoma | 0.000542884 | 2 | 0 | BeFree |
| Endometrial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
| Infective dermatitis | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000542884 | 2 | 0 | BeFree |
| Pulmonary arterial hypertension | 0.000542884 | 2 | 0 | BeFree |
| Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 0.000542884 | 2 | 0 | BeFree |
| Acquired Immunodeficiency Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Congenital arteriovenous malformation | 0.000271442 | 1 | 0 | BeFree |
| Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Carcinoid Tumor | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Hepatic Fibrosis, Congenital | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Dry Eye Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Ganglioneuroma | 0.000271442 | 1 | 0 | BeFree |
| Gastroesophageal reflux disease | 0.000271442 | 1 | 0 | BeFree |
| Hemangioma | 0.000271442 | 1 | 0 | BeFree |
| Hemangiosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Mammary Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Keratoconjunctivitis | 0.000271442 | 1 | 1 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lichen Sclerosus et Atrophicus | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nodule | 0.000271442 | 1 | 0 | BeFree |
| oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Papilloma | 0.000271442 | 1 | 0 | BeFree |
| Parasitic Diseases | 0.000271442 | 1 | 0 | BeFree |
| Pneumonia | 0.000271442 | 1 | 0 | BeFree |
| polyps | 0.000271442 | 1 | 0 | BeFree |
| Purpura, Thrombotic Thrombocytopenic | 0.000271442 | 1 | 0 | BeFree |
| Paraparesis, Spastic | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
| Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Peripheral Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Polymyositis | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Systemic candidiasis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of penis | 0.000271442 | 1 | 0 | BeFree |
| Hypertrophy of kidney | 0.000271442 | 1 | 0 | BeFree |
| Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of penis | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Lewis Lung | 0.000271442 | 1 | 0 | BeFree |
| Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
| Malignant Childhood Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| T-cell adult acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Obesity, Abdominal | 0.000271442 | 1 | 0 | BeFree |
| Dryness of eye | 0.000271442 | 1 | 0 | BeFree |
| High-Grade Squamous Intraepithelial Lesions | 0.000271442 | 1 | 0 | BeFree |
| Clear cell sarcoma of kidney | 0.000271442 | 1 | 0 | BeFree |
| Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Corticosteroid-induced glaucoma | 0.000271442 | 1 | 0 | BeFree |
| Human T-cell lymphotrophic virus, type I [HTLV-I] | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Overweight | 0.000271442 | 1 | 0 | BeFree |
| Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Alveolitis | 0.000271442 | 1 | 0 | BeFree |
| Cutaneous hypersensitivity | 0.000271442 | 1 | 0 | BeFree |
| Aqueous Humor Disorders | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Sentinel node (disorder) | 0.000271442 | 1 | 0 | BeFree |
| inflammatory joint disease | 0.000271442 | 1 | 0 | BeFree |
| Skin carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Dissecting aneurysm of the thoracic aorta | 0.000271442 | 1 | 0 | BeFree |
| Parasitic infection | 0.000271442 | 1 | 0 | BeFree |
| Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
| Inclusion Body Myopathy, Sporadic | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Thrombocytosis | 0.000271442 | 1 | 0 | BeFree |
| Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
| Penis carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Pancreatic Ductal | 0.000271442 | 1 | 0 | BeFree |
| Arteriovenous Malformations, Cerebral | 0.000271442 | 1 | 0 | BeFree |
| Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
| Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
| Vascular occlusion | 0.000271442 | 1 | 0 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Corneal allograft rejection | 0.000271442 | 1 | 0 | BeFree |
| Primary Effusion Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Radial scar | 0.000271442 | 1 | 0 | BeFree |
| Low Grade Squamous Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Liver regeneration disorder | 0.000271442 | 1 | 0 | BeFree |
| Congenital Mesoblastic Nephroma | 0.000271442 | 1 | 0 | BeFree |
| Gastric Cardia Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Infiltrating Cervical Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Oligodendroglial Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
| Neuropathogenesis | 0.000271442 | 1 | 0 | BeFree |
| Ocular surface disease | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Direct Contact Transmission Infection | 0.000271442 | 1 | 0 | BeFree |
| Malformations of Cortical Development, Group II | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal Atresia, Encephalocele, and Limb Deformities | 0.000271442 | 1 | 0 | BeFree |
| Stiff Skin Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Thrombotic thrombocytopenic purpura, acquired | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Obesity, Visceral | 0.000271442 | 1 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
| Fibromyxosarcoma | 0.000271442 | 1 | 0 | BeFree |
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