THAP1(THAP domain containing, apoptosis associated protein 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

8p11.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质包含一个THAP结构域，保守的DNA结合结构域。这种蛋白质与共定位凋亡响应蛋白PAWR / PAR-4在早幼粒细胞白血病（PML）核机构，并且用作链接PAWR到PML核小体一个促凋亡因子。编码不同同种型的可变剪接转录物变体已观察到。 [由RefSeq的，2008年7月提供]

OMIM数据库中对THAP1基因的介绍     Wikipedia数据库中对THAP1基因的介绍

基因序列

基因序列

THAP1基因的碱基序列：[NCBI]

基因突变

基因突变

THAP1基因的碱基突变：           显示全部snp
rs1298675       rs3211072       rs4299997       rs4737075       rs10107916       rs11557527       rs11995681       rs59523223       rs59531993       rs59923100       rs61747267       rs62515902       rs71521601       rs72644042       rs73634656       rs73634659       rs73634664       rs73634666       rs73634670       rs73675436       rs73675437       rs75420572       rs77913717       rs78565597       rs79811377       rs111989331       rs112417915       rs112538292       rs113163526       rs113408810       rs113756309       rs114447974       rs115021200       rs116026791       rs138020622       rs138126515       rs138345513      
rs138955420       rs139105087       rs139380947       rs139446246       rs140206609       rs140668058       rs140694378       rs141393467       rs141527709       rs141658821       rs142802423       rs142852933       rs142884956       rs143138265       rs143788957       rs144111248       rs146087734       rs146119069       rs146146764       rs146195365       rs146451906       rs146832894       rs147011517       rs147847344       rs148565279       rs149254140       rs150282653       rs150542583       rs180682027       rs180960596       rs181246380       rs181381128       rs181590307       rs181767250       rs181850921       rs182319418       rs182651293       rs182877153       rs183231952       rs183552863       rs183920650       rs184004672       rs184244017       rs184302304       rs184483796       rs184497763       rs184900161       rs185264166       rs185999636       rs186110922       rs186300436       rs186352130       rs187465688       rs187688842       rs187943266       rs188042901       rs188244091       rs188389632       rs188935767       rs189443762       rs189660984       rs189683667       rs189728728       rs190502385       rs190646222       rs191034081       rs191313881       rs191317424       rs192149179       rs192352714       rs192644802       rs192803799       rs193223903       rs200196616       rs200209986       rs201010904       rs201431250       rs201973882       rs202128051       rs202165165       rs368815106       rs369328057       rs369357686       rs369406881       rs369461161       rs370082539       rs370132548       rs370983900       rs371606502       rs372080941       rs372100039       rs373836581       rs373843959       rs374512193       rs376416004       rs376448985       rs376577376       rs377034494       rs377725442       rs527466112       rs527668370       rs528126268       rs528366078       rs528665742       rs528740497       rs528807483       rs529820677       rs530175900       rs530209812       rs531112336       rs531198311       rs531274078       rs532057258       rs532547179       rs532785465       rs532941744       rs533639671       rs533999489       rs534146061       rs534340207       rs534427925       rs534532604       rs534749643       rs534947228       rs535492803       rs535615196       rs535818634       rs536312700       rs536495435       rs536531001       rs536618371       rs536990981       rs537093686       rs537181381       rs537752803       rs538267559       rs538295567       rs538456433       rs540243879       rs540762559       rs540766244       rs540926551       rs540966698       rs541083208       rs542388570       rs543106396       rs543618832       rs543655906       rs543951003       rs544840638       rs545007718       rs545431903       rs545891683       rs545930392       rs546113385       rs546707639       rs547402922       rs547826107       rs547877744       rs547937632       rs547970180       rs548133580       rs548595515       rs549933424       rs549972439       rs550357912       rs550683185       rs551168043       rs551291803       rs551815208       rs552709637       rs552912656       rs552972493       rs554000924       rs554222026       rs554234453       rs554345104       rs554789711       rs555505284       rs555729129       rs555784949       rs555814606       rs556422716       rs556767684       rs556983053       rs557236829       rs558437147       rs558579136       rs558814623       rs559563279       rs559810051       rs559934080       rs560047833       rs560706030       rs561379422       rs562267010       rs562302097       rs563040351       rs563463528       rs564109319       rs564614705       rs564748365       rs564777855       rs565322150       rs565529942       rs565697275       rs567881303       rs568070828       rs569031620       rs569272780       rs569336455       rs569828608       rs569869075       rs570028670       rs570102944       rs570414218       rs570575495       rs570690311       rs571060311       rs571654066       rs571737563       rs571780087       rs571899747       rs573066840       rs573181569       rs574421287       rs574444269       rs574487492       rs574531295       rs574596774       rs575469114       rs575621426       rs576818958       rs576857627       rs577105893       rs577136573       rs577174492       rs577435142       rs578211534       rs578251005       rs745439069       rs745551712       rs746957334       rs747246177       rs747958352       rs748129133       rs748325390       rs748328560       rs748449414       rs748940828       rs749031048       rs749342762       rs749414480       rs749421564       rs749882767       rs749949383       rs750569333       rs750659053       rs751000436       rs751550215       rs752337324       rs753062454       rs753450906       rs753670048       rs754103591       rs754189565       rs754896042       rs755330097       rs755416189       rs755865233       rs756308909       rs756473499       rs756694303       rs756850917       rs757044592       rs757498036       rs757584681       rs758497993       rs758882685       rs758926260       rs759022351       rs759057359       rs759392096       rs759430545       rs760064965       rs760617709       rs761006483       rs761059207       rs761249200       rs761376417       rs761774859       rs762418293       rs762507901       rs764467954       rs764536678       rs764667950       rs764799510       rs765509619       rs766379247       rs766458232       rs766483829       rs766936494       rs766943512       rs767519301       rs767952378       rs768017019       rs768559786       rs768826037       rs768850503       rs768944055       rs769370716       rs769617686       rs769746038       rs769988455       rs770527058       rs771561925       rs771720832       rs772552734       rs772824192       rs772913962       rs773282992       rs773643417       rs773679247       rs773869932       rs773963967       rs774148629       rs774720567       rs775605048       rs775747589       rs775952915       rs776323533       rs776431729       rs776713979       rs776801688       rs777248739       rs777572276       rs777742589       rs778036542       rs778597447       rs778653023       rs779647395       rs779964974       rs780201146       rs781048457       rs781412919       rs796340648      

基因表达

基因表达

THAP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CAAGCCCGTTTCTTTCCAC
60
TCAACCTGGGAAACAGGAG
59
AGCTTCAGGTTTCCTCTTACTC
60
CAAATACTGCTATACTTGGTGGG
59
CAAGCCCGTTTCTTTCCAC
60
ATCAACCTGGGAAACAGGA
59
TTCCACAAGTTTCCTCTTACTC
58
ATACTGCTATACTTGGTGGGT
58
CAAGCCCGTTTCTTTCCAC
60
ATCAACCTGGGAAACAGGAG
60
AGCTTCAGGTTTCCTCTTACTC
60
AATACTGCTATACTTGGTGGGT
59
AGAAAGCTTCAGGTTTCCTC
58
ACTGCTATACTTGGTGGGT
58
TTCCACAAGTTTCCTCTTACTC
58
ACTGCTATACTTGGTGGGT
58
CTTTACTCCAGACTGCTTTAAGAG
59
ATCTTCTTTCTTGTCATGTGGC
59
TTCCACAAGTTTCCTCTTACTC
58
TACTGCTATACTTGGTGGGT
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

THAP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

THAP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003676
E9PIS9(UniProtKB)
IEA
GO:0001935
Q9NVV9(UniProtKB)
IMP
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005515
Q9NVV9(UniProtKB)
IPI
GO:0005634
Q9NVV9(UniProtKB)
IDA
GO:0005634
Q9NVV9(UniProtKB)
IDA
GO:0005730
Q9NVV9(UniProtKB)
IDA
GO:0006351
Q9NVV9(UniProtKB)
IMP
GO:0006355
Q9NVV9(UniProtKB)
IMP
GO:0007049
Q9NVV9(UniProtKB)
IEA
GO:0007346
Q9NVV9(UniProtKB)
IMP
GO:0008270
Q9NVV9(UniProtKB)
IDA
GO:0008270
Q9NVV9(UniProtKB)
IDA
GO:0016605
Q9NVV9(UniProtKB)
IEA
GO:0042802
Q9NVV9(UniProtKB)
IPI
GO:0042802
Q9NVV9(UniProtKB)
IPI
GO:0042802
Q9NVV9(UniProtKB)
IPI
GO:0043231
Q9NVV9(UniProtKB)
IDA
GO:0043565
Q9NVV9(UniProtKB)
IDA
GO:0043565
Q9NVV9(UniProtKB)
IDA
GO:0043565
Q9NVV9(UniProtKB)
IDA
GO:0043565
Q9NVV9(UniProtKB)
IMP
GO:0043565
Q9NVV9(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控THAP1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Dystonia 6, torsion (disorder) 0.480542884 16 5 BeFree_CLINVAR_CTD_human_ORPHANET_UNIPROT
Dystonia 0.137415887 39 0 BeFree_CTD_human_GAD
Dystonia Disorders 0.134777413 38 0 BeFree_CTD_human_GAD
Dystonia, Primary 0.005700279 21 0 BeFree
DYSTONIA 1, TORSION, AUTOSOMAL DOMINANT 0.002714419 10 0 BeFree
Dystonia Musculorum Deformans 0.002442977 9 0 BeFree
Generalized dystonia 0.002171535 8 0 BeFree
Pili torti-deafness syndrome 0.001357209 5 0 BeFree
Cervical Dystonia 0.001357209 5 0 BeFree
Spastic Dysphonia 0.000542884 2 0 BeFree
Focal Dystonia 0.000542884 2 0 BeFree
Familial Dystonia 0.000542884 2 0 BeFree
Dystonia 3, Torsion, X-Linked 0.000542884 2 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000542884 2 0 BeFree
Segmental dystonia 0.000542884 2 0 BeFree
Oromandibular dystonia 0.000542884 2 0 BeFree
Blepharospasm 0.000271442 1 0 BeFree
Dyskinetic syndrome 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Myoclonus 0.000271442 1 0 BeFree
Parkinson Disease 0.000271442 1 0 BeFree
Motor symptoms 0.000271442 1 0 BeFree
Stomach Carcinoma 0.000271442 1 0 BeFree
Adult-Onset Dystonias 0.000271442 1 0 BeFree
Basal ganglia calcification 0.000271442 1 0 BeFree
Laryngeal dystonia 0.000271442 1 0 BeFree
Benign essential blepharospasm 0.000271442 1 0 BeFree

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