TFE3基因详情-基因数据库-基因云馆

TFE3(transcription factor binding to IGHM enhancer 3) 转至新版数据库

基因简称(symbol)

TFE3 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

TFEA|bHLHe33

基因家族代码(gene_family_id)

420 [HGNC] [GenScript]

omim代码

314310

entrez码

7030 [Vega]

vega基因码

OTTHUMG00000022690

ensembl基因码

ENSG00000068323 [Ensembl]

基因家族(gene family)

Basic helix-loop-helix proteins

refseq数据库代号

NM_006521

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

Xp11.22

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

1990-10-16T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

更新时间(date_modified)

2014-11-19T00:00:00Z

ucsc码

uc004dmb.4

ena

X96717

ccds数据码

CCDS14315

uniprot数据码

P19532

pubmed代码

1672758|1685140

mgd码

MGI:98511

rgd码

RGD:1559642

生命科学数据库(lsdb)

Mental Retardation database|http://grenada.lumc.nl/LOVD2/MR/home.php?select_db=TFE3

更新时间(date modified)

2014-11-19T00:00:00Z

cosmic

TFE3

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

homeodb

cosmic

TFE3

snornabase

bioparadigms slc

orphanet

120036

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

Xp11.22

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

[中文简述(自动翻译):] 该基因编码能结合在基因的启动子MUE3型E盒序列的碱性螺旋 - 环 - 螺旋结构域的转录因子。所编码的蛋白质促进转化生长因子β（TGF-β）信号的下游基因的表达。该基因可能参与在肾细胞癌和其他癌症染色体易位，导致生产融合蛋白。易位合作伙伴包括PRCC（乳头状肾细胞癌），NONO（含，八聚体结合非POU域），以及ASPSCR1（腺泡状软组织肉瘤染色体区域，候选1），其他基因。选择性剪接结果在多个抄本变形。 [由RefSeq的，2013年8月提供]

OMIM数据库中对TFE3基因的介绍 Wikipedia数据库中对TFE3基因的介绍

TFE3基因的碱基序列：[NCBI]

TFE3基因的碱基突变：显示全部snp

rs1047561 rs1047568 rs1209829 rs2904112 rs3027470 rs3027471 rs3027472 rs3027473 rs3027474 rs3788818 rs3950204 rs4824738 rs7056903 rs7878591 rs7879023 rs7888202 rs9778458 rs12007166 rs12011849 rs12012438 rs12012692 rs12557627 rs28372230 rs34558907 rs35988387 rs41305381 rs41305383 rs58261578 rs58754355 rs58791973 rs58910174 rs59121676 rs59403483 rs59817553 rs60309712 rs61004534 rs61385282

rs62600359 rs73632396 rs73632397 rs77063550 rs79978776 rs111410005 rs111544621 rs112777640 rs113550878 rs113854587 rs138806194 rs138839277 rs139188133 rs139889590 rs140332391 rs140565162 rs140733414 rs141152393 rs141452086 rs141702671 rs142072134 rs142320710 rs142370390 rs143070691 rs143365037 rs144431753 rs144622262 rs145106323 rs145321303 rs145602217 rs146046652 rs146065189 rs146935940 rs147100760 rs147559555 rs147902906 rs147974460 rs148346861 rs148539112 rs149375412 rs149428328 rs149649619 rs149686739 rs149741986 rs149950072 rs150773704 rs150779978 rs181030468 rs181120439 rs181465589 rs181983885 rs182218319 rs182234236 rs182466732 rs182949487 rs183023161 rs183263932 rs183368194 rs183848529 rs184031139 rs184332393 rs184634249 rs185122798 rs185415465 rs185587819 rs185907477 rs186007858 rs186337523 rs186512677 rs186739258 rs186811951 rs187034058 rs187076727 rs187163790 rs187313034 rs187824016 rs187907638 rs188320836 rs188457910 rs188488197 rs188693389 rs188734999 rs189185965 rs189222789 rs190011509 rs190130367 rs190735265 rs190736521 rs190789496 rs191255599 rs191324126 rs191501187 rs191538163 rs191541206 rs191754528 rs192133171 rs192156376 rs192304551 rs192647547 rs192855348 rs193113651 rs193206969 rs199560694 rs199894897 rs200293583 rs200863939 rs201049883 rs201168885 rs201808352 rs202095583 rs202170639 rs367560398 rs367755411 rs367827397 rs368191647 rs368263592 rs368527575 rs368895179 rs369475777 rs369572083 rs369858357 rs370070686 rs370608867 rs370693170 rs370865595 rs371538827 rs371578460 rs371723359 rs372314452 rs372564649 rs372595070 rs373045428 rs373639502 rs373846907 rs373899230 rs374071577 rs374270871 rs374474638 rs374872426 rs376015528 rs376043279 rs376250395 rs376385160 rs376659299 rs377088709 rs377187631 rs377533245 rs781784291 rs781787823 rs781792105 rs781800168 rs781810957 rs781825487 rs781826791 rs781832923 rs781835191 rs781835878 rs781836515 rs781840386 rs781841913 rs781842431 rs781842859 rs781845261 rs781846546 rs781846888 rs781849100 rs781857429 rs781858237 rs781859773 rs781862116 rs781862455 rs781863465 rs781866057 rs781868281 rs781872256 rs781872643 rs781873227 rs781873272 rs781873695 rs781875127 rs781879799 rs781880655 rs781884534 rs781885410 rs781887371 rs781888101 rs781889886 rs781891286 rs781892917 rs781897154 rs781900286 rs781901001 rs781902132 rs781905591 rs781913450 rs781913966 rs781915738 rs781918284 rs781920102 rs781923098 rs781924118 rs781924132 rs781925356 rs781927976 rs781929039 rs781929644 rs781929782 rs781932892 rs781935512 rs781936583 rs781939637 rs781940632 rs781942513 rs781948743 rs781949099 rs781951301 rs781953279 rs781953513 rs781953839 rs781959074 rs781963537 rs781963745 rs781969126 rs781970950 rs781971245 rs781985132 rs781985731 rs781989780 rs781993470 rs781994354 rs781996328 rs781999310 rs781999503 rs782000566 rs782003825 rs782004079 rs782004627 rs782006378 rs782006875 rs782010251 rs782012535 rs782016022 rs782018183 rs782025279 rs782026714 rs782027002 rs782027549 rs782029710 rs782032021 rs782034465 rs782034488 rs782036553 rs782037153 rs782038990 rs782046863 rs782052564 rs782053872 rs782055516 rs782056325 rs782057273 rs782063602 rs782065396 rs782068672 rs782070258 rs782072452 rs782074238 rs782075514 rs782079245 rs782082061 rs782082456 rs782083484 rs782085281 rs782088860 rs782089605 rs782089868 rs782095573 rs782097519 rs782106588 rs782107746 rs782109239 rs782109836 rs782109897 rs782110385 rs782113966 rs782114663 rs782115411 rs782115854 rs782115945 rs782118149 rs782129959 rs782133905 rs782137762 rs782137812 rs782138130 rs782139708 rs782142662 rs782146194 rs782147491 rs782148893 rs782151651 rs782152448 rs782159878 rs782160305 rs782161086 rs782163082 rs782164493 rs782167555 rs782168821 rs782170342 rs782173190 rs782174132 rs782175501 rs782177459 rs782180603 rs782182621 rs782183525 rs782183904 rs782188306 rs782189927 rs782193138 rs782195089 rs782197843 rs782199756 rs782205722 rs782205895 rs782206443 rs782207056 rs782207856 rs782213833 rs782216331 rs782218564 rs782220410 rs782228674 rs782228992 rs782229569 rs782232076 rs782235189 rs782238700 rs782239289 rs782246480 rs782247742 rs782251433 rs782251878 rs782256627 rs782259761 rs782261224 rs782263710 rs782266557 rs782271311 rs782272958 rs782273328 rs782274424 rs782280641 rs782282065 rs782282280 rs782283460 rs782283859 rs782287085 rs782291962 rs782296286 rs782297479 rs782299569 rs782306835 rs782314136 rs782316429 rs782318768 rs782319184 rs782320148 rs782328428 rs782329572 rs782333221 rs782335625 rs782336772 rs782337988 rs782339241 rs782340173 rs782341363 rs782342097 rs782342716 rs782344736 rs782346414 rs782347207 rs782351636 rs782352042 rs782352356 rs782352878 rs782355417 rs782357804 rs782358848 rs782358989 rs782360202 rs782360972 rs782363556 rs782364680 rs782366021 rs782366463 rs782367719 rs782368049 rs782369351 rs782370157 rs782371710 rs782375848 rs782376412 rs782377455 rs782378464 rs782384434 rs782389911 rs782391412 rs782393296 rs782396637 rs782398277 rs782400823 rs782401158 rs782402484 rs782402838 rs782407790 rs782410988 rs782411703 rs782419971 rs782421009 rs782426041 rs782426592 rs782428510 rs782430999 rs782431595 rs782432988 rs782433389 rs782434076 rs782436702 rs782437015 rs782437066 rs782444177 rs782445226 rs782446365 rs782452603 rs782454473 rs782455447 rs782456065 rs782457379 rs782458928 rs782462580 rs782463855 rs782466724 rs782467109 rs782467939 rs782468772 rs782469616 rs782477723 rs782484357 rs782485856 rs782490443 rs782492795 rs782493540 rs782494248 rs782495968 rs782499491 rs782500227 rs782509704 rs782516347 rs782516855 rs782517158 rs782521367 rs782522606 rs782524028 rs782528810 rs782529128 rs782530972 rs782531998 rs782532797 rs782534661 rs782535682 rs782535970 rs782537130 rs782538136 rs782543806 rs782548608 rs782548893 rs782551260 rs782553054 rs782553082 rs782554829 rs782555413 rs782555753 rs782560515 rs782564349 rs782567354 rs782568769 rs782569678 rs782571382 rs782577298 rs782582723 rs782584186 rs782584600 rs782592808 rs782593756 rs782596719 rs782597619 rs782601169 rs782605789 rs782607653 rs782608249 rs782608594 rs782610401 rs782610698 rs782613018 rs782613886 rs782614013 rs782614531 rs782616594 rs782619958 rs782629226 rs782631288 rs782632980 rs782635252 rs782636157 rs782637716 rs782637840 rs782638809 rs782641526 rs782645296 rs782645839 rs782651544 rs782655357 rs782656388 rs782658083 rs782659769 rs782660872 rs782662992 rs782664226 rs782666638 rs782669755 rs782670973 rs782672539 rs782675010 rs782675616 rs782679964 rs782683383 rs782686901 rs782690241 rs782692948 rs782694624 rs782697975 rs782699562 rs782699889 rs782700190 rs782701013 rs782702269 rs782711014 rs782712731 rs782716693 rs782717067 rs782720147 rs782721783 rs782722034 rs782722360 rs782725136 rs782727365 rs782728627 rs782729118 rs782730179 rs782731107 rs782735670 rs782735701 rs782737875 rs782740611 rs782743948 rs782746815 rs782750132 rs782752177 rs782753958 rs782756569 rs782759681 rs782764078 rs782766621 rs782767466 rs782769489 rs782772793 rs782776048 rs782776666 rs782782345 rs782783392 rs782784061 rs782787513 rs782788989 rs782790328 rs782790681 rs782792379 rs782793883 rs782798695 rs782798757 rs782798965 rs782806624 rs782809252 rs782811600 rs782812641 rs782816369 rs782817614 rs782817960 rs782819731 rs782820846

TFE3基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

CTCCAAAGACCTGGAGAGC

59

AGTTCTAGTTCCTGAATTCGGA

59

CAGAGAAGGAGATTGATGATGTC

58

CAGACCAACCTCCCATCTC

59

CAGAGAAGGAGATTGATGATGTC

58

GACCAACCTCCCATCTCAG

59

CTCCAAAGACCTGGAGAGC

59

CAGTTCTAGTTCCTGAATTCGG

58

AGAGAAGGAGATTGATGATGTC

57

ATCAAGCAGATTCCCTGAC

57

AGAGAAGGAGATTGATGATGTC

57

GGTGATACAGAAATGCCCT

57

CAGAGAAGGAGATTGATGATGTC

58

CAAGCAGATTCCCTGACAC

58

CAGAGAAGGAGATTGATGATGTC

58

AGCAGATTCCCTGACACAG

59

GCTCCAAAGACCTGGAGAG

59

AGTTCTAGTTCCTGAATTCGGA

59

尚未收录相关数据

TFE3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

TFE3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000978

P19532(UniProtKB)

IEA

GO:0001077

P19532(UniProtKB)

IEA

GO:0002250

P19532(UniProtKB)

IEA

GO:0003700

P19532(UniProtKB)

ISS

GO:0005634

P19532(UniProtKB)

IMP

GO:0005654

P19532(UniProtKB)

IDA

GO:0005737

P19532(UniProtKB)

IDA

GO:0006366

P19532(UniProtKB)

IEA

GO:0006959

P19532(UniProtKB)

ISS

GO:0044212

P19532(UniProtKB)

ISS

GO:0045670

P19532(UniProtKB)

IEA

GO:0045785

P19532(UniProtKB)

IMP

GO:0045944

P19532(UniProtKB)

ISS

GO:0045944

P19532(UniProtKB)

IMP

GO:0046983

P19532(UniProtKB)

IEA

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控TFE3基因的相关microRNA：

hsa-miR-335 hsa-miR-200b hsa-miR-200b* hsa-miR-200c hsa-miR-200c* hsa-miR-455-3p

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Renal Cell Carcinoma	0.148249818	85	0	BeFree_CTD_human_LHGDN
Alveolar Soft Part Sarcoma	0.127057489	26	0	BeFree_ORPHANET
Epithelioid hemangioendothelioma	0.120814326	3	0	BeFree_ORPHANET
RENAL CELL CARCINOMA, Xp11-ASSOCIATED	0.12	0	0	ORPHANET
Perivascular Epithelioid Cell Neoplasms	0.005710211	12	0	BeFree_LHGDN
Renal carcinoma	0.005428837	20	0	BeFree
Sarcoma	0.004895885	9	0	BeFree_LHGDN
Kidney Neoplasm	0.003528744	13	0	BeFree
Malignant neoplasm of kidney	0.002171535	8	0	BeFree
Papillary Renal Cell Carcinoma	0.001628651	6	0	BeFree
Microphthalmos	0.001085767	4	0	BeFree
Diabetes	0.000814326	3	0	BeFree
Diabetes Mellitus	0.000814326	3	0	BeFree
Neoplasm Metastasis	0.000814326	3	0	BeFree
Conventional (Clear Cell) Renal Cell Carcinoma	0.000814326	3	0	BeFree
Epithelioid hemangioendothelioma, malignant	0.000814326	3	0	BeFree
Carcinogenesis	0.000814326	3	0	BeFree
Childhood Renal Cell Carcinoma	0.000814326	3	0	BeFree
Clear-cell metastatic renal cell carcinoma	0.000814326	3	0	BeFree
Sarcoma, Clear Cell	0.000542884	2	0	BeFree
Metastatic Renal Cell Cancer	0.000542884	2	0	BeFree
Adenocarcinoma	0.000271442	1	0	BeFree
Adenoid Cystic Carcinoma	0.000271442	1	0	BeFree
Hemangiosarcoma	0.000271442	1	0	BeFree
Hyperglycemia	0.000271442	1	0	BeFree
Lymphoma	0.000271442	1	0	BeFree
Metabolic Diseases	0.000271442	1	0	BeFree
Nephroblastoma	0.000271442	1	0	BeFree
Neuroblastoma	0.000271442	1	0	BeFree
Osteopetrosis	0.000271442	1	0	BeFree
Retinal Degeneration	0.000271442	1	0	BeFree
Retinoblastoma	0.000271442	1	0	BeFree
Soft Tissue Neoplasms	0.000271442	1	0	BeFree
Wiskott-Aldrich Syndrome	0.000271442	1	0	BeFree
Granular cell tumor	0.000271442	1	0	BeFree
Acute appendicitis NOS (disorder)	0.000271442	1	0	BeFree
Mesoblastic Nephroma	0.000271442	1	0	BeFree
Retinal damage	0.000271442	1	0	BeFree
Vascular Neoplasms	0.000271442	1	0	BeFree
Metabolic Syndrome X	0.000271442	1	0	BeFree
Adrenal neuroblastoma	0.000271442	1	0	BeFree
Central neuroblastoma	0.000271442	1	0	BeFree
Histiocytoma, Angiomatoid Fibrous	0.000271442	1	0	BeFree
Congenital Mesoblastic Nephroma	0.000271442	1	0	BeFree
Radiation-Related Angiosarcoma	0.000271442	1	0	BeFree