TCL1A(T-cell leukemia/lymphoma 1A) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

14q32.1
基因染色体位置图

基因简述

基因简述

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

[中文简述(自动翻译):]  人类中TCL1基因的过表达已在成熟T细胞白血病的发展，其中，染色体重排使TCL1基因在接近T细胞抗原受体（TCR）-α-牵连（MIM 186880）或TCR-β（MIM 186930）的调节元件（由维尔吉利奥等人，1998年[搜索PubMed 9520462]总结）。在正常的T细胞TCL1在CD4- / CD8-细胞中表达，但不能在分化的后期阶段的细胞。 TCL1用作细胞存活激酶AKT的共活化剂（MIM 164730）（莱恩等人，2000 [搜索PubMed 10983986]）。[由OMIM，2010年7月供给]

OMIM数据库中对TCL1A基因的介绍     Wikipedia数据库中对TCL1A基因的介绍

基因序列

基因序列

TCL1A基因的碱基序列：[NCBI]

基因突变

基因突变

TCL1A基因的碱基突变：           显示全部snp
rs728739       rs1122138       rs1123245       rs1951989       rs1957936       rs1957937       rs1984967       rs1984968       rs2209399       rs2296311       rs2296312       rs2887399       rs3831076       rs11846938       rs11849538       rs17093285       rs17093288       rs17093294       rs45509491       rs58314705       rs60303382       rs73350139       rs73350146       rs74087818       rs74551977       rs74608547       rs74608909       rs75213274       rs75353825       rs75402640       rs75659766       rs75675056       rs76003389       rs76924794       rs76947975       rs77796335       rs77989678      
rs78796306       rs79582761       rs79966636       rs111247694       rs112098209       rs112225511       rs112533660       rs112842119       rs113327601       rs113750717       rs115193606       rs115447128       rs115581414       rs115762343       rs115987524       rs116015209       rs117312585       rs117430118       rs138342827       rs138395361       rs138967660       rs139012944       rs139184818       rs139445257       rs139748489       rs139963283       rs140113793       rs140270177       rs141291616       rs141384924       rs141586311       rs141964306       rs142093293       rs142183284       rs142206584       rs142526263       rs142911529       rs143282939       rs143354400       rs143694806       rs143921625       rs143985445       rs144370504       rs145224919       rs145774862       rs145860355       rs146226332       rs146561494       rs146705048       rs147126151       rs147441509       rs148164020       rs148367980       rs148612702       rs149106856       rs149488686       rs149840194       rs150271502       rs150398513       rs150516075       rs150661254       rs151199857       rs181117535       rs181532547       rs181945968       rs182344938       rs182380241       rs182521834       rs182680123       rs183462181       rs183555736       rs183644040       rs184161091       rs184225200       rs184579898       rs184924934       rs185093566       rs185731765       rs186005870       rs186505168       rs186557069       rs186716827       rs186920279       rs187378757       rs187560020       rs187611233       rs187989772       rs188093012       rs188733186       rs188793291       rs188987535       rs189271546       rs189620203       rs190456702       rs190539102       rs190661971       rs190947006       rs191153065       rs191298008       rs191670127       rs191912954       rs192014637       rs192036434       rs192159437       rs192696144       rs193090425       rs193157851       rs199936672       rs200115937       rs200322588       rs200758121       rs200858233       rs201228671       rs201835893       rs201931789       rs202164556       rs202169011       rs367806687       rs367961867       rs369144655       rs369903773       rs370393806       rs370455598       rs370796806       rs371421469       rs371593636       rs371622034       rs372143792       rs372316449       rs372385287       rs372524587       rs373039386       rs373340060       rs373576522       rs374389743       rs374706524       rs374784310       rs375262475       rs375313256       rs376088645       rs376398114       rs376401914       rs376511499       rs377598728       rs527956018       rs528260515       rs528356309       rs528386453       rs528439141       rs528444246       rs528549381       rs528577516       rs529162432       rs529449343       rs529606593       rs529706188       rs529737544       rs529818479       rs529843739       rs530095532       rs530792099       rs530829822       rs530893432       rs530990632       rs531479581       rs532058626       rs532088384       rs532142212       rs532190592       rs532483398       rs532542814       rs532686275       rs533503156       rs534127772       rs534430219       rs534478894       rs534549460       rs534679282       rs534688397       rs534797298       rs535588276       rs535694583       rs535805644       rs535834997       rs535870792       rs535944752       rs535981778       rs536046384       rs536080594       rs536141835       rs537006898       rs537234016       rs537270924       rs538125176       rs538360168       rs538399607       rs538461202       rs538535701       rs538696382       rs538978960       rs539359923       rs539614886       rs539663744       rs539775193       rs540259705       rs540391225       rs540551148       rs540579476       rs540704019       rs540855591       rs541037378       rs541389234       rs541673148       rs541809458       rs542220767       rs542764031       rs542927682       rs543440244       rs544012123       rs544133903       rs544751064       rs544819275       rs545191546       rs545710784       rs545809740       rs545894707       rs545902265       rs546212306       rs546471182       rs546597677       rs546722328       rs546729242       rs546816096       rs546930386       rs547342810       rs547633625       rs547678507       rs547867567       rs547903922       rs547961226       rs548171737       rs549089464       rs549110206       rs549202006       rs549321794       rs550235417       rs550306005       rs550313177       rs550790415       rs550903655       rs551346453       rs551434163       rs551678957       rs551905898       rs552192530       rs552773977       rs552806437       rs552900130       rs552935726       rs553014196       rs553654593       rs553861137       rs553914701       rs554102531       rs554779494       rs554947556       rs555115522       rs555135401       rs555390835       rs555561249       rs555917829       rs556003967       rs556024198       rs556658801       rs556755593       rs556757039       rs556795890       rs556844801       rs557219682       rs557668294       rs558033363       rs558391942       rs558868728       rs558965307       rs559073952       rs559109959       rs559731354       rs559986769       rs560011205       rs560150169       rs560482818       rs560491904       rs560506812       rs561040302       rs561114820       rs561181672       rs561192375       rs561227835       rs561638598       rs561674978       rs562261963       rs562847448       rs562874493       rs562955493       rs563186226       rs563393948       rs563514740       rs563901610       rs564194550       rs564196861       rs564859826       rs565098676       rs565123767       rs565339302       rs565405196       rs565599302       rs565790316       rs565918044       rs565979768       rs565992296       rs566051116       rs566145285       rs566162501       rs566258193       rs566271738       rs566277338       rs566496926       rs567307767       rs567364658       rs567366276       rs567451819       rs567595569       rs568339282       rs568560767       rs568701643       rs569742644       rs569759831       rs569830173       rs569893442       rs569962364       rs569999160       rs570392615       rs571055768       rs571174544       rs571356991       rs571543617       rs572046775       rs572095594       rs572229588       rs572287421       rs572379561       rs572540850       rs573041117       rs573153681       rs573241286       rs573333443       rs573336118       rs573656363       rs573896893       rs574222083       rs574259790       rs574346935       rs574433150       rs574652957       rs574855224       rs574942855       rs574993529       rs575490968       rs575576498       rs575719036       rs576076603       rs576717944       rs577022176       rs577156857       rs577371696       rs577502312       rs577589953       rs577906007       rs578167591       rs745436032       rs745655183       rs746026619       rs746507043       rs746814229       rs747190817       rs747608446       rs747916728       rs748449083       rs748550266       rs748896184       rs749057622       rs749370204       rs749386790       rs749612170       rs749766826       rs750215320       rs751280210       rs751325443       rs751644622       rs751750592       rs751987105       rs752623073       rs752798507       rs752906787       rs753154908       rs753729360       rs753909442       rs754379290       rs754713863       rs755141222       rs755614627       rs755719496       rs755930947       rs756246653       rs756351534       rs756981751       rs757197357       rs757350575       rs757882590       rs758149368       rs758302705       rs758951029       rs759110794       rs759883480       rs760853895       rs760969174       rs761711862       rs761885678       rs762137745       rs762263577       rs762444739       rs762460896       rs762960464       rs762986307       rs763228152       rs763303471       rs763542286       rs763913610       rs764191158       rs764919368       rs765540578       rs765560693       rs766277282       rs766302311       rs766396309       rs766723100       rs766811067       rs767368380       rs767707209       rs767730962       rs768263629       rs768365954       rs769015153       rs769399500       rs769516941       rs769702518       rs770376517       rs770415882       rs770871736       rs771109532       rs771351412       rs772348647       rs772366831       rs772465102       rs773203292       rs773217679       rs773340204       rs773356556       rs773625180       rs773793274       rs774364531       rs774830071       rs774868084       rs774976994       rs775038049       rs775056251       rs775321262       rs776043410       rs776131557       rs776337946       rs776819931       rs777191687       rs777477449       rs778722375       rs778810255       rs779489723       rs779753371       rs779872846       rs780310562       rs780332557       rs780732844       rs781184290       rs781263317       rs781485777      

基因表达

基因表达

TCL1A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGATGACTGATGTCTTGGC
57
GAACAGAAACACAACATCCC
57
TATCATGTGGCAGCTCTACC
59
GCCGTCAATCTTGATGTGG
59
ATGACTGATGTCTTGGCAG
58
GAACAGAAACACAACATCCC
57
CGTGTATTTGGACGAGAAGC
59
GAGACCCTGTATCTCGATGG
59
ACCATCGAGATAAAGGATAGGT
58
AGAGCTGCCACATGATAGG
59
ACCATCGAGATAAAGGATAGGT
58
AGAGCTGCCACATGATAGG
59
CGTGTATTTGGACGAGAAGC
59
GAGACCCTGTATCTCGATGG
59
CTTAACCATCGAGATAAAGGATAGG
59
AGAGCTGCCACATGATAGG
59
TATCATGTGGCAGCTCTACC
59
GCCGTCAATCTTGATGTGG
59
ATCATGTGGCAGCTCTACC
60
CGCCGTCAATCTTGATGTG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

TCL1A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

TCL1A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005515
P56279(UniProtKB)
IPI
GO:0005634
P56279(UniProtKB)
IEA
GO:0005783
P56279(UniProtKB)
IEA
GO:0007275
P56279(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控TCL1A基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Chronic Lymphocytic Leukemia 0.020659377 47 0 BeFree_LHGDN
Lymphoma 0.016054797 23 0 BeFree_LHGDN
Leukemia, T-Cell 0.014667793 45 0 BeFree_LHGDN
leukemia 0.008153188 21 0 BeFree_LHGDN
T-Cell Prolymphocytic Leukemia 0.006795978 15 0 BeFree_LHGDN
B-Cell Lymphomas 0.006253095 14 0 BeFree_LHGDN
Leukemia, T-Cell, Chronic 0.003257302 12 0 BeFree
Bacterial Infections 0.00272435 1 0 LHGDN
Heart failure 0.002638474 1 3 BeFree_GAD
Animal Mammary Neoplasms 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Mammary Neoplasms 0.002367032 1 0 GAD
Ataxia Telangiectasia 0.002171535 8 0 BeFree
Leukemogenesis 0.001900093 7 0 BeFree
Prolymphocytic Leukemia 0.001357209 5 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.001357209 5 0 BeFree
Diffuse Large B-Cell Lymphoma 0.001357209 5 0 BeFree
Burkitt Lymphoma 0.000542884 2 0 BeFree
Congenital chromosomal disease 0.000542884 2 0 BeFree
Lymphoid leukemia 0.000542884 2 0 BeFree
Acute lymphocytic leukemia 0.000542884 2 0 BeFree
Leukemia, Myelocytic, Acute 0.000542884 2 0 BeFree
Lymphoproliferative Disorders 0.000542884 2 0 BeFree
Multiple Myeloma 0.000542884 2 0 BeFree
Peripheral T-Cell Lymphoma 0.000542884 2 0 BeFree
Lymphoma, AIDS-Related 0.000542884 2 0 BeFree
Epstein-Barr Virus Infections 0.000542884 2 0 BeFree
Isochromosomes 0.000542884 2 0 BeFree
Splenic Marginal Zone B-Cell Lymphoma 0.000542884 2 0 BeFree
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Fatigue 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Hepatomegaly 0.000271442 1 0 BeFree
Angioimmunoblastic Lymphadenopathy 0.000271442 1 0 BeFree
Immunologic Deficiency Syndromes 0.000271442 1 0 BeFree
Lymphoma, Follicular 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Seminoma 0.000271442 1 0 BeFree
T-Cell Lymphoma 0.000271442 1 0 BeFree
Spastic syndrome 0.000271442 1 0 BeFree
childhood small noncleaved cell lymphoma 0.000271442 1 0 BeFree
Solid tumour 0.000271442 1 0 BeFree
Lymphoid hyperplasia 0.000271442 1 0 BeFree
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 0.000271442 1 0 BeFree
Hyperplastic lymph node 0.000271442 1 0 BeFree
Disseminated Malignant Neoplasm 0.000271442 1 0 BeFree
Hematologic Neoplasms 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Cardiomyopathies 0.000271442 1 0 BeFree
Primary cutaneous B-cell lymphoma 0.000271442 1 0 BeFree
Chronic leukemia (category) 0.000271442 1 0 BeFree
Primary Effusion Lymphoma 0.000271442 1 0 BeFree
Mediastinal (Thymic) Large B-Cell Lymphoma 0.000271442 1 0 BeFree
Precursor B-cell lymphoblastic leukemia 0.000271442 1 0 BeFree
Hepatosplenic T-cell lymphoma 0.000271442 1 0 BeFree
Precursor Lymphoid Neoplasm 0.000271442 1 0 BeFree
Hepatocarcinogenesis 0.000271442 1 0 BeFree
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree

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