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The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质是转录激活,发挥在淋巴细胞分化中起重要作用。该基因是在T细胞中表达。所编码的蛋白质可以结合增强子元件并激活CD3E基因,并且它也可以通过反馈机制抑制的CTNNB1和TCF7L2基因。已发现该基因编码不同亚型的几个抄本变形。 [由RefSeq的,2011年10月提供]
TCF7基因(以及对应的蛋白质)的细胞分布位置:
TCF7基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.010901282 | 17 | 0 | BeFree_GAD |
| Inflammation | 0.007101096 | 3 | 0 | GAD |
| Diabetes Mellitus, Insulin-Dependent | 0.006362715 | 7 | 1 | BeFree_GAD |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Cancer | 0.002638474 | 2 | 0 | BeFree_GAD |
| Maturity onset diabetes mellitus in young | 0.002442977 | 9 | 0 | BeFree |
| Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
| Chlamydia Infections | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
| Trachoma | 0.002367032 | 1 | 0 | GAD |
| Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
| Coronary Artery Disease | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus | 0.002171535 | 8 | 0 | BeFree |
| Diabetes | 0.001900093 | 7 | 0 | BeFree |
| Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
| Adenoma | 0.000814326 | 3 | 0 | BeFree |
| Hepatocellular Adenoma | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder) | 0.000814326 | 3 | 0 | BeFree |
| Impaired glucose tolerance | 0.000542884 | 2 | 0 | BeFree |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Hypoglycemia | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Precursor cell lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Peripheral T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Chronic disease of respiratory system | 0.000271442 | 1 | 0 | BeFree |
| Multiple adenomatous polyps | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central Core Myopathy (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Lymphoepithelioid lymphoma (clinical) | 0.000271442 | 1 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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