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This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
[中文简述(自动翻译):]  这个基因编码包含蛋白激酶结构域,硫氰酸酶样结构域和TRE-2 / Bub2 / Cdc16(TBC)结构域的蛋白质。所编码的蛋白质被认为是通过调节信号转导通路的雷帕霉素(mTOR的)的哺乳动物靶标发挥肌动蛋白的组织,细胞生长和细胞增殖的作用。这种蛋白可能也参与了mTOR的复合物的组成部分的转录调控。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年3月提供]
TBCK基因(以及对应的蛋白质)的细胞分布位置:
TBCK基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Seizure Adverse Event | 0.12 | 0 | 1 | CLINVAR |
| Ventral septal defect (VSD) | 0.12 | 0 | 1 | CLINVAR |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
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