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The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
[中文简述(自动翻译):]  这个基因的产物是所涉及的途径,导致从折叠中间体正确折叠的β-微管蛋白四种蛋白质(辅因子A,D,E和C)中的一个。辅因子A和D被认为发挥捕获和在准本地确认稳定的β-微管蛋白的中间体的作用。 ?辅结合辅助因子D /测试微管蛋白复合物;与辅?相互作用进而导致那些致力于天然状态的β-微管蛋白多肽的释放。该基因编码伴侣辅A.多选择性剪接转录变异体的编码不同亚型也发现了这种基因。 [由RefSeq的,2014年7月提供]
TBCA基因(以及对应的蛋白质)的细胞分布位置:
TBCA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertrophic Cardiomyopathy | 0.12 | 1 | 0 | CTD_human |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Diarrhea | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
Diphtheria | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
prostatitis | 0.000271442 | 1 | 0 | BeFree |
Polyendocrinopathies, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Hypokinesia | 0.000271442 | 1 | 0 | BeFree |
Inflammatory pain | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Mechanical Allodynia | 0.000271442 | 1 | 0 | BeFree |
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