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This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  该基??因编码四种产品的速激肽激素家族,P物质和神经激肽A的,以及相关的肽,神经肽K和神经肽伽马。这些激素被认为充当其与神经受体和平滑肌细胞相互作用的神经递质。它们被称为诱导行为反应并用作血管扩张剂和分泌。 P物质是具有抗菌和抗真菌特性的抗微生物肽。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2014年11月提供]
TAC1基因(以及对应的蛋白质)的细胞分布位置:
TAC1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Pain | 0.203724241 | 10 | 1 | BeFree_CTD_human_GAD_RGD |
Inflammation | 0.20272435 | 5 | 0 | CTD_human_LHGDN_RGD |
Hypotension | 0.2 | 3 | 0 | CTD_human_RGD |
Bradycardia | 0.2 | 3 | 0 | CTD_human_RGD |
Neurogenic Inflammation | 0.2 | 6 | 0 | CTD_human_RGD |
Schizophrenia | 0.122909916 | 3 | 0 | BeFree_CTD_human_GAD |
Gastroesophageal reflux disease | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Bipolar Disorder | 0.120271442 | 1 | 0 | BeFree_CTD_human |
Bronchial Hyperreactivity | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Major Depressive Disorder | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Amnesia | 0.12 | 3 | 0 | CTD_human |
Corneal Diseases | 0.12 | 1 | 0 | CTD_human |
Drug Eruptions | 0.12 | 1 | 0 | CTD_human |
Drug Allergy | 0.12 | 1 | 0 | CTD_human |
Edema | 0.12 | 1 | 0 | CTD_human |
Extravasation of Diagnostic and Therapeutic Materials | 0.12 | 2 | 0 | CTD_human |
Hyperalgesia | 0.12 | 9 | 0 | CTD_human |
Hyperemia | 0.12 | 2 | 0 | CTD_human |
Hypersensitivity | 0.12 | 1 | 0 | CTD_human |
Narcolepsy | 0.12 | 1 | 0 | CTD_human |
Neuralgia | 0.12 | 1 | 0 | CTD_human |
Pruritus | 0.12 | 1 | 0 | CTD_human |
Sialorrhea | 0.12 | 1 | 0 | CTD_human |
Common Migraine | 0.12 | 1 | 0 | CTD_human |
Arthritis, Experimental | 0.12 | 1 | 0 | CTD_human |
Colitis | 0.087348794 | 10 | 0 | BeFree_LHGDN_RGD |
Respiratory Syncytial Virus Infections | 0.082638474 | 3 | 0 | BeFree_GAD_RGD |
Pulmonary Hypertension | 0.08 | 1 | 0 | RGD |
Sleep Apnea, Central | 0.08 | 1 | 0 | RGD |
Asthma | 0.014992773 | 11 | 1 | BeFree_GAD_LHGDN |
Sleep Apnea, Obstructive | 0.005720142 | 2 | 0 | BeFree_LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Multiple Sclerosis | 0.00554839 | 3 | 0 | BeFree_GAD |
Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Rheumatoid Arthritis | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Diarrhea | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Degenerative polyarthritis | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Primary Myelofibrosis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Dermatitis, Atopic | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.003257302 | 12 | 0 | BeFree |
Breast Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Coughing | 0.002995792 | 2 | 1 | BeFree_LHGDN |
Cryptosporidiosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Glioma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Neuroblastoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Atrial Fibrillation | 0.00272435 | 1 | 0 | LHGDN |
Myeloproliferative disease | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Astrocytoma | 0.002714419 | 10 | 0 | BeFree |
Autistic Disorder | 0.002638474 | 2 | 0 | BeFree_GAD |
HIV Infections | 0.002442977 | 9 | 0 | BeFree |
Acute Disease | 0.002367032 | 1 | 0 | GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Low Back Pain | 0.002367032 | 1 | 0 | GAD |
Pain, Postoperative | 0.002367032 | 1 | 0 | GAD |
Reflex Sympathetic Dystrophy | 0.002367032 | 1 | 0 | GAD |
Sciatica | 0.002367032 | 1 | 0 | GAD |
Inflammatory Bowel Diseases | 0.002171535 | 8 | 0 | BeFree |
Mood Disorders | 0.001900093 | 7 | 0 | BeFree |
Anxiety Disorders | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001628651 | 6 | 0 | BeFree |
Prostate carcinoma | 0.001628651 | 6 | 0 | BeFree |
Mental Depression | 0.001357209 | 5 | 0 | BeFree |
Depressive disorder | 0.001357209 | 5 | 0 | BeFree |
Fibromyalgia | 0.001357209 | 5 | 0 | BeFree |
Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
Ulcerative Colitis | 0.001085767 | 4 | 0 | BeFree |
Pancreatitis, Chronic | 0.001085767 | 4 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Cysticercosis | 0.000814326 | 3 | 0 | BeFree |
Endometriosis | 0.000814326 | 3 | 0 | BeFree |
Irritable Bowel Syndrome | 0.000814326 | 3 | 0 | BeFree |
leukemia | 0.000814326 | 3 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000814326 | 3 | 0 | BeFree |
Neuronal Ceroid-Lipofuscinoses | 0.000814326 | 3 | 0 | BeFree |
Ichthyosis Bullosa of Siemens | 0.000814326 | 3 | 0 | BeFree |
Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
Ceroid lipofuscinosis, neuronal 1, infantile | 0.000814326 | 3 | 0 | BeFree |
Acute pancreatitis | 0.000542884 | 2 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Constipation | 0.000542884 | 2 | 0 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Eczema | 0.000542884 | 2 | 0 | BeFree |
Globus Hystericus | 0.000542884 | 2 | 0 | BeFree |
Myelofibrosis | 0.000542884 | 2 | 0 | BeFree |
Psoriasis | 0.000542884 | 2 | 0 | BeFree |
Rett Syndrome | 0.000542884 | 2 | 0 | BeFree |
Synovial Cyst | 0.000542884 | 2 | 0 | BeFree |
Chronic pain | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
Infantile neuronal ceroid lipofuscinosis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Neurodegenerative Disorders | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Myxoid cyst | 0.000542884 | 2 | 0 | BeFree |
Tendinosis | 0.000542884 | 2 | 0 | BeFree |
Abdominal Pain | 0.000271442 | 1 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 1 | BeFree |
Anorexia | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cholestasis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Enteritis | 0.000271442 | 1 | 0 | BeFree |
Epidemic keratoconjunctivitis | 0.000271442 | 1 | 0 | BeFree |
Fibrodysplasia Ossificans Progressiva | 0.000271442 | 1 | 0 | BeFree |
Helminthiasis | 0.000271442 | 1 | 0 | BeFree |
Hematological Disease | 0.000271442 | 1 | 0 | BeFree |
Hernia | 0.000271442 | 1 | 1 | BeFree |
Pain in lower limb | 0.000271442 | 1 | 0 | BeFree |
Mastocytosis | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 1 | BeFree |
Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Ptosis | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Burn scar | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Sudden infant death syndrome | 0.000271442 | 1 | 0 | BeFree |
Synovitis | 0.000271442 | 1 | 0 | BeFree |
Tachycardia | 0.000271442 | 1 | 0 | BeFree |
Thyroiditis | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Urticaria Pigmentosa | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Vomiting | 0.000271442 | 1 | 0 | BeFree |
Hypokinesia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Cholera | 0.000271442 | 1 | 0 | BeFree |
Left Ventricular Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Lower respiratory tract infection | 0.000271442 | 1 | 0 | BeFree |
Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
Teratocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Ganglioneuroblastoma | 0.000271442 | 1 | 0 | BeFree |
CHRONIC CRYPTOSPORIDIOSIS | 0.000271442 | 1 | 0 | BeFree |
Parkinsonian Disorders | 0.000271442 | 1 | 0 | BeFree |
Chronic urticaria | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic Infections | 0.000271442 | 1 | 0 | BeFree |
Disseminated neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Neurocysticercosis | 0.000271442 | 1 | 0 | BeFree |
Alternating hemiplegia of childhood | 0.000271442 | 1 | 0 | BeFree |
Mixed anxiety and depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone marrow | 0.000271442 | 1 | 0 | BeFree |
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | 0.000271442 | 1 | 0 | BeFree |
Anxiety and fear | 0.000271442 | 1 | 0 | BeFree |
Gastrointestinal symptom | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
Acute asthma | 0.000271442 | 1 | 0 | BeFree |
Tactile Allodynia | 0.000271442 | 1 | 0 | BeFree |
Carotid Artery Plaque | 0.000271442 | 1 | 0 | BeFree |
nasal allergy | 0.000271442 | 1 | 0 | BeFree |
Vascular inflammations | 0.000271442 | 1 | 0 | BeFree |
Stage 4S neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Persistent infection | 0.000271442 | 1 | 0 | BeFree |
Diverticulosis | 0.000271442 | 1 | 0 | BeFree |
Neuropathogenesis | 0.000271442 | 1 | 0 | BeFree |
DYSTONIA 12 | 0.000271442 | 1 | 0 | BeFree |
Irritable bowel syndrome characterized by constipation | 0.000271442 | 1 | 0 | BeFree |
Bladder pain syndrome | 0.000271442 | 1 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
Pneumonitis | 0.000271442 | 1 | 1 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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