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The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
[中文简述(自动翻译):]  的synaptotagmins被认为是作为钙离子在囊泡运输和胞吐的过程传感器突触小泡的膜蛋白。在突触触发神经递质释放的钙结合到突触-1参与(费尔南德斯 - 查孔。等,2001年[搜索PubMed 11242035])。[由OMIM,2010年7月供给]
SYT1基因(以及对应的蛋白质)的细胞分布位置:
SYT1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Seizures | 0.08 | 1 | 0 | RGD |
| synovial sarcoma | 0.03040149 | 112 | 0 | BeFree |
| Neoplasm Metastasis | 0.003800186 | 14 | 0 | BeFree |
| Sarcoma | 0.003528744 | 13 | 0 | BeFree |
| Epilepsy | 0.002638474 | 2 | 0 | BeFree_GAD |
| Mental Retardation | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Serum creatinine level | 0.002367032 | 1 | 0 | GAD |
| Attention deficit hyperactivity disorder | 0.002367032 | 1 | 0 | GAD |
| Breast Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Stomach Carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Liver carcinoma | 0.001900093 | 7 | 0 | BeFree |
| Ulcerative Colitis | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.001628651 | 6 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001628651 | 6 | 0 | BeFree |
| Prostate carcinoma | 0.001628651 | 6 | 0 | BeFree |
| Colorectal Cancer | 0.001628651 | 6 | 0 | BeFree |
| Squamous cell carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.001357209 | 5 | 0 | BeFree |
| Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Cervix carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.001357209 | 5 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant tumor of cervix | 0.001085767 | 4 | 0 | BeFree |
| Hyperglycemia | 0.001085767 | 4 | 0 | BeFree |
| Multiple Myeloma | 0.001085767 | 4 | 0 | BeFree |
| Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.001085767 | 4 | 0 | BeFree |
| Thyroid carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.001085767 | 4 | 0 | BeFree |
| Monophasic Synovial Sarcoma | 0.001085767 | 4 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000814326 | 3 | 0 | BeFree |
| Asthma | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colitis | 0.000814326 | 3 | 0 | BeFree |
| Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
| melanoma | 0.000814326 | 3 | 0 | BeFree |
| Septicemia | 0.000814326 | 3 | 0 | BeFree |
| Sepsis | 0.000814326 | 3 | 0 | BeFree |
| Helicobacter pylori infection | 0.000814326 | 3 | 0 | BeFree |
| Synovial sarcoma non-metastatic | 0.000814326 | 3 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
| Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Esophageal Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Fibrosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| Herpes Simplex Infections | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Ischemia | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Medulloblastoma | 0.000542884 | 2 | 0 | BeFree |
| Nasal Polyps | 0.000542884 | 2 | 0 | BeFree |
| Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
| Reticuloendotheliosis, X-linked | 0.000542884 | 2 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Neuroectodermal Tumor, Primitive | 0.000542884 | 2 | 0 | BeFree |
| Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
| Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000542884 | 2 | 0 | BeFree |
| Malignant Peripheral Nerve Sheath Tumor | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Promyelocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
| Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
| Amebiasis | 0.000271442 | 1 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Anemia, Sickle Cell | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
| Bone Diseases | 0.000271442 | 1 | 0 | BeFree |
| Bone neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Bronchopneumonia | 0.000271442 | 1 | 0 | BeFree |
| Brucellosis | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Cystitis | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Amebic colitis | 0.000271442 | 1 | 0 | BeFree |
| Eclampsia | 0.000271442 | 1 | 0 | BeFree |
| Eczema | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Gingivitis | 0.000271442 | 1 | 0 | BeFree |
| Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
| Hemorrhagic Fever with Renal Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
| Hypersplenism | 0.000271442 | 1 | 0 | BeFree |
| Hyperthyroidism | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
| Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Periodontitis | 0.000271442 | 1 | 0 | BeFree |
| Pityriasis Rubra Pilaris | 0.000271442 | 1 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
| Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of testis | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Undifferentiated carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
| Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Hantavirus Infections | 0.000271442 | 1 | 0 | BeFree |
| Parathyroid Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Endometrioma | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis, Central Nervous System | 0.000271442 | 1 | 0 | BeFree |
| Rhinovirus infection | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
| Synovial sarcoma, biphasic | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Steroid-resistant nephrotic syndrome | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| airway disease | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
| Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Drug Resistant Epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
| Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Liposarcoma, well differentiated | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Glucocorticoid Receptor Deficiency | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
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