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This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
[中文简述(自动翻译):]  该基因属于中stathmin基因家族。它编码提出以用作胞内中继积分蜂窝环境的调节信号一个无处不在胞质磷蛋白。所编码的蛋白质是参与微管灯丝系统由去稳定微管的调节。它可以防止装配和促进微管拆卸。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2009年2月提供]
STMN1基因(以及对应的蛋白质)的细胞分布位置:
STMN1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Glioma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Prostatic Neoplasms | 0.120542884 | 2 | 0 | BeFree_CTD_human |
Mammary Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Spinal Muscular Atrophy | 0.08 | 304 | 0 | BeFree |
Multiple Sclerosis | 0.005362824 | 2 | 1 | BeFree_GAD_LHGDN |
Neuromuscular Diseases | 0.004614512 | 17 | 0 | BeFree |
Motor Neuron Disease | 0.004614512 | 17 | 0 | BeFree |
Adenocarcinoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Pheochromocytoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.003800186 | 14 | 0 | BeFree |
Breast Carcinoma | 0.003800186 | 14 | 0 | BeFree |
Squamous cell carcinoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.003528744 | 13 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.003257302 | 12 | 0 | BeFree |
Neurodegenerative Disorders | 0.002985861 | 11 | 0 | BeFree |
Alzheimer's Disease | 0.00272435 | 1 | 0 | LHGDN |
Down Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Acute Erythroblastic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
oligodendroglioma | 0.00272435 | 1 | 0 | LHGDN |
HMN (Hereditary Motor Neuropathy) Proximal Type I | 0.002714419 | 10 | 0 | BeFree |
Tumor Progression | 0.002714419 | 10 | 0 | BeFree |
Liver carcinoma | 0.002714419 | 10 | 0 | BeFree |
leukemia | 0.001900093 | 7 | 0 | BeFree |
Paresis | 0.001900093 | 7 | 0 | BeFree |
Muscle Weakness | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
Degenerative disorder | 0.001628651 | 6 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Muscular Atrophy | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001357209 | 5 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.001085767 | 4 | 0 | BeFree |
Colorectal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001085767 | 4 | 0 | BeFree |
Neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Motor Neuron Disease, Lower | 0.001085767 | 4 | 0 | BeFree |
Endometrial Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Stomach Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Uterine Corpus Cancer | 0.001085767 | 4 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Protein Deficiency | 0.000814326 | 3 | 0 | BeFree |
Juvenile Spinal Muscular Atrophy | 0.000814326 | 3 | 0 | BeFree |
Pancreatic carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
Sarcoma | 0.000814326 | 3 | 0 | BeFree |
Hepatocarcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000542884 | 2 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Respiratory Failure | 0.000542884 | 2 | 0 | BeFree |
Amyotrophic Lateral Sclerosis, Sporadic | 0.000542884 | 2 | 0 | BeFree |
Amyotrophy, monomelic | 0.000542884 | 2 | 0 | BeFree |
Urothelial Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Anorexia Nervosa | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Arthrogryposis | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Charcot-Marie-Tooth Disease | 0.000271442 | 1 | 0 | BeFree |
Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Coughing | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Eating Disorders | 0.000271442 | 1 | 0 | BeFree |
Ependymoma | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Gigantism | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Muscle Cramp | 0.000271442 | 1 | 0 | BeFree |
Myopathy | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Spinal Diseases | 0.000271442 | 1 | 0 | BeFree |
Post-Traumatic Stress Disorder | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Polymyositis | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Infections, Parvovirus | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Self-induced vomiting | 0.000271442 | 1 | 0 | BeFree |
Islet Cell Tumor | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Myelopathic Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Endometrial neoplasm malignant metastatic | 0.000271442 | 1 | 0 | BeFree |
Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma in situ of fallopian tube | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Anxiety and fear | 0.000271442 | 1 | 0 | BeFree |
Neuropathy | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Familial Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Malignant Squamous Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Heredodegenerative Disorders, Nervous System | 0.000271442 | 1 | 0 | BeFree |
Spots on skin | 0.000271442 | 1 | 0 | BeFree |
Progressive Muscular Atrophy | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
Hereditary Malignant Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Stage IIA Esophageal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Marginal Zone B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Differentiating Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant | 0.000271442 | 1 | 0 | BeFree |
AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.000271442 | 1 | 0 | BeFree |
Bisphosphonate-associated osteonecrosis | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
High grade serous carcinoma | 0.000271442 | 1 | 0 | BeFree |
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