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This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因,其编码的丝氨酸/苏氨酸激酶家族的一个成员,调节细胞极性和用作肿瘤抑制基因。在这种基因突变与黑斑息肉综合征,常染色体显性遗传疾病在胃肠道特征息肉的生长有关,对皮肤和嘴和其他肿瘤色素斑。该基因的备选的转录剪接变体已被观察到,但没有被完全表征。 [由RefSeq的,2008年7月提供]
STK11基因(以及对应的蛋白质)的细胞分布位置:
STK11基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Peutz-Jeghers Syndrome | 0.664198424 | 187 | 24 | BeFree_CLINVAR_CTD_human_GAD_LHGDN_MGD_ORPHANET_UNIPROT |
Testicular Germ Cell Tumor | 0.24 | 1 | 0 | CTD_human_UNIPROT |
Adenocarcinoma | 0.145413304 | 30 | 0 | BeFree_CTD_human_GAD_LHGDN |
Lung Neoplasms | 0.141070234 | 17 | 0 | BeFree_CTD_human_GAD_LHGDN |
Squamous cell carcinoma | 0.1343502 | 8 | 0 | BeFree_CTD_human_GAD_LHGDN |
Adenocarcinoma of lung (disorder) | 0.122714419 | 10 | 0 | BeFree_CTD_human |
Pancreatic Neoplasm | 0.122638474 | 3 | 0 | BeFree_CTD_human_GAD |
Pancreatic carcinoma | 0.122171535 | 8 | 3 | BeFree_CLINVAR |
Malignant neoplasm of testis | 0.120542884 | 2 | 1 | BeFree_CLINVAR |
Hypertensive disease | 0.12 | 1 | 0 | CTD_human |
Neoplastic Syndromes, Hereditary | 0.12 | 0 | 23 | CLINVAR |
Left Ventricular Hypertrophy | 0.12 | 1 | 0 | CTD_human |
Intestinal Polyposis | 0.12 | 1 | 0 | CTD_human |
MELANOMA, CUTANEOUS MALIGNANT, 1 | 0.12 | 0 | 4 | CLINVAR |
Insulin Resistance | 0.082367032 | 2 | 0 | GAD_RGD |
Endometrial Carcinoma | 0.081085767 | 4 | 0 | BeFree_MGD |
Obesity | 0.080271442 | 2 | 0 | BeFree_RGD |
Malignant neoplasm of lung | 0.023974099 | 40 | 0 | BeFree_GAD |
Carcinogenesis | 0.010857675 | 40 | 0 | BeFree |
Carcinoma of lung | 0.009229024 | 34 | 0 | BeFree |
Neoplasm Metastasis | 0.008153188 | 21 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.007795869 | 20 | 0 | BeFree_GAD |
Hamartoma | 0.007057489 | 26 | 1 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005819831 | 5 | 0 | BeFree_GAD |
melanoma | 0.005710211 | 11 | 0 | BeFree_LHGDN |
Non-Small Cell Lung Carcinoma | 0.005700279 | 21 | 0 | BeFree |
polyps | 0.005700279 | 21 | 0 | BeFree |
Breast Carcinoma | 0.005428837 | 20 | 0 | BeFree |
Polycystic Ovary Syndrome | 0.005276948 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.004734064 | 2 | 1 | GAD |
Tuberous Sclerosis | 0.004353001 | 6 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Hamartomatous polyp | 0.003257302 | 12 | 0 | BeFree |
Diabetes Mellitus | 0.002909916 | 3 | 0 | BeFree_GAD |
Carcinoma, Large Cell | 0.002909916 | 3 | 0 | BeFree_GAD |
Cardiomegaly | 0.00272435 | 1 | 0 | LHGDN |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of pancreas | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 0 | BeFree_GAD |
Hyperandrogenism | 0.002638474 | 1 | 1 | BeFree_GAD |
Tumor Progression | 0.002442977 | 9 | 1 | BeFree |
Cervix carcinoma | 0.002442977 | 9 | 0 | BeFree |
Multiple polyps | 0.002442977 | 9 | 0 | BeFree |
Hyperinsulinism | 0.002367032 | 1 | 0 | GAD |
Long QT Syndrome | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Torsades de Pointes | 0.002367032 | 1 | 0 | GAD |
Malignant tumor of cervix | 0.002171535 | 8 | 0 | BeFree |
Colorectal Cancer | 0.002171535 | 8 | 0 | BeFree |
Malignant tumor of colon | 0.001900093 | 7 | 0 | BeFree |
Liver carcinoma | 0.001900093 | 7 | 0 | BeFree |
Colorectal Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Ovarian Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001357209 | 5 | 0 | BeFree |
Adenoma | 0.001085767 | 4 | 1 | BeFree |
Malignant neoplasm of endometrium | 0.001085767 | 4 | 0 | BeFree |
Colorectal Neoplasms | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Juvenile polyposis syndrome | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Stomach Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Uterine Corpus Cancer | 0.001085767 | 4 | 0 | BeFree |
Esophageal Neoplasms | 0.000814326 | 3 | 0 | BeFree |
Hamartoma Syndrome, Multiple | 0.000814326 | 3 | 0 | BeFree |
Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Metabolic Diseases | 0.000814326 | 3 | 0 | BeFree |
Esophageal carcinoma | 0.000814326 | 3 | 0 | BeFree |
Breast Cancer, Familial | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000814326 | 3 | 0 | BeFree |
Biliary Tract Cancer | 0.000814326 | 3 | 0 | BeFree |
ovarian neoplasm | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
Bronchioloalveolar Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Uterine Cervical Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Hyperglycemia | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 1 | BeFree |
Testicular Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Thecoma | 0.000542884 | 2 | 0 | BeFree |
Metastatic malignant neoplasm to brain | 0.000542884 | 2 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000542884 | 2 | 1 | BeFree |
Cancer of Head and Neck | 0.000542884 | 2 | 0 | BeFree |
Carney Complex | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 1 | BeFree |
Testicular malignant germ cell tumor | 0.000542884 | 2 | 0 | BeFree |
Hereditary Nonpolyposis Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Basal Cell Nevus Syndrome | 0.000271442 | 1 | 0 | BeFree |
Bladder Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
fibroma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Gynecomastia | 0.000271442 | 1 | 0 | BeFree |
Intussusception | 0.000271442 | 1 | 0 | BeFree |
Laryngeal neoplasm | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Multiple Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Myeloproliferative disease | 0.000271442 | 1 | 0 | BeFree |
Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Ovarian Diseases | 0.000271442 | 1 | 0 | BeFree |
Retroviridae Infections | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Gestational Diabetes | 0.000271442 | 1 | 1 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
Familial Atypical Multiple Mole-Melanoma | 0.000271442 | 1 | 0 | BeFree |
Adenomyoma | 0.000271442 | 1 | 0 | BeFree |
Acinar Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Non-small cell lung cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Acinar cell carcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervical Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
Hyperplastic Polyp | 0.000271442 | 1 | 0 | BeFree |
Gastric Hamartoma | 0.000271442 | 1 | 0 | BeFree |
Precocious pubarche | 0.000271442 | 1 | 1 | BeFree |
Human papilloma virus infection | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Large cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
Stromal tumor of ovary | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
polyp benign | 0.000271442 | 1 | 0 | BeFree |
Oculo-dento-digital syndrome | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Liver regeneration disorder | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | 0.000271442 | 1 | 0 | BeFree |
TUBEROUS SCLEROSIS 1 (disorder) | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Familial Atypical Mole Melanoma Syndrome | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma, familial | 0.000271442 | 1 | 0 | BeFree |
Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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