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The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是STAT蛋白家族的一个成员。响应于细胞因子和生长因子,STAT家族成员是由受体相关的激酶磷酸化,然后形成同源该转位到细胞核,其中它们作为转录激活剂或异二聚体。这种蛋白质可通过多种配体,包括干扰素-α,干扰素-γ,EGF,PDGF和IL6被激活。该蛋白介导的各种基因,这被认为是对细胞活力重要响应于不同的细胞刺激和病原体的表达。两个编码不同同种型的可变剪接转录物变体已有描述。 [由RefSeq的,2008年7月提供]
STAT1基因(以及对应的蛋白质)的细胞分布位置:
STAT1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
IMMUNODEFICIENCY 31B | 0.36 | 2 | 4 | CLINVAR_ORPHANET_UNIPROT |
Candidiasis, Chronic Mucocutaneous | 0.243800186 | 14 | 3 | BeFree_CTD_human_ORPHANET |
CANDIDIASIS, FAMILIAL, 7 | 0.24 | 2 | 15 | CLINVAR_UNIPROT |
IMMUNODEFICIENCY 31A | 0.24 | 3 | 0 | ORPHANET_UNIPROT |
Arthritis, Experimental | 0.2 | 2 | 0 | CTD_human_RGD |
Liver carcinoma | 0.125624334 | 13 | 0 | BeFree_CTD_human_GAD |
Mycobacterium Infections | 0.123257302 | 13 | 0 | BeFree_CTD_human |
Liver Cirrhosis | 0.122638474 | 3 | 0 | BeFree_CTD_human_GAD |
Rheumatoid Arthritis | 0.122171535 | 9 | 0 | BeFree_CTD_human |
Cytomegalovirus Infections | 0.12 | 1 | 0 | CTD_human |
Influenza | 0.12 | 1 | 0 | CTD_human |
Mycobacterium Infections, Nontuberculous | 0.12 | 0 | 0 | CTD_human |
Disease Progression | 0.12 | 1 | 0 | CTD_human |
hearing impairment | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Pulmonary Fibrosis | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 2 | 0 | RGD |
Sepsis | 0.08 | 1 | 0 | RGD |
Trauma, Nervous System | 0.08 | 1 | 0 | RGD |
Infection | 0.016346101 | 6 | 0 | LHGDN |
Hepatitis C, Chronic | 0.008186863 | 7 | 0 | BeFree_GAD |
Multiple Sclerosis | 0.007729856 | 3 | 0 | BeFree_GAD_LHGDN |
Lupus Erythematosus, Systemic | 0.007448483 | 10 | 1 | BeFree_GAD |
Virus Diseases | 0.00706742 | 16 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.006167218 | 15 | 0 | BeFree_GAD |
melanoma | 0.005981653 | 13 | 0 | BeFree_LHGDN |
Glioblastoma | 0.005905708 | 5 | 0 | BeFree_GAD_LHGDN |
Hepatitis C | 0.005634266 | 4 | 0 | BeFree_GAD_LHGDN |
Anoxia | 0.0054487 | 2 | 0 | LHGDN |
Asthma | 0.003995683 | 7 | 0 | BeFree_GAD |
Chronic Lymphocytic Leukemia | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Myeloid Leukemia, Chronic | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Carcinogenesis | 0.003800186 | 14 | 0 | BeFree |
Liver neoplasms | 0.003724241 | 6 | 0 | BeFree_GAD |
Lymphoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
HIV Infections | 0.003528744 | 13 | 0 | BeFree |
Celiac Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Breast Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Hepatitis B | 0.003181358 | 4 | 0 | BeFree_GAD |
Acute Erythroblastic Leukemia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Lymphoma, Follicular | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Mumps | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Respiratory Syncytial Virus Infections | 0.002909916 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.002909916 | 3 | 0 | BeFree_GAD |
Hepatitis B, Chronic | 0.002909916 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of ovary | 0.002909916 | 3 | 0 | BeFree_GAD |
Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Choriocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Cystic Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Hyperinsulinism | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Sjogren's Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of urinary bladder | 0.002638474 | 2 | 0 | BeFree_GAD |
Glioma | 0.002638474 | 1 | 0 | BeFree_GAD |
Myeloid Leukemia | 0.002638474 | 2 | 0 | BeFree_GAD |
Chronic Obstructive Airway Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Osteoporosis | 0.002638474 | 1 | 0 | BeFree_GAD |
Tuberculosis | 0.002638474 | 2 | 0 | BeFree_GAD |
Diffuse Large B-Cell Lymphoma | 0.002638474 | 2 | 0 | BeFree_GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Campylobacter infection | 0.002367032 | 1 | 0 | GAD |
Immediate hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Neutropenia | 0.002367032 | 1 | 0 | GAD |
Salmonella infections | 0.002367032 | 1 | 0 | GAD |
Thrombocytopenia | 0.002367032 | 1 | 0 | GAD |
Thyroid Neoplasm | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Viremia | 0.002367032 | 1 | 0 | GAD |
Arthritis, Reactive | 0.002367032 | 1 | 0 | GAD |
Medullary carcinoma | 0.002367032 | 1 | 0 | GAD |
Malignant tumor of colon | 0.001628651 | 6 | 0 | BeFree |
Colon Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Arteriosclerosis | 0.001357209 | 5 | 0 | BeFree |
Atherosclerosis | 0.001357209 | 5 | 0 | BeFree |
Mycoses | 0.001357209 | 5 | 0 | BeFree |
Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
Squamous cell carcinoma | 0.001085767 | 4 | 0 | BeFree |
Multiple Myeloma | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.001085767 | 4 | 0 | BeFree |
Congenital Abnormality | 0.000814326 | 3 | 1 | BeFree |
Candidiasis | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
Herpes encephalitis | 0.000814326 | 3 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
Primary immune deficiency disorder | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
Sarcoma | 0.000814326 | 3 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Ulcerative Colitis | 0.000542884 | 2 | 1 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Fanconi Anemia | 0.000542884 | 2 | 0 | BeFree |
Gingival Diseases | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Measles | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Periodontal Diseases | 0.000542884 | 2 | 0 | BeFree |
Polycythemia Vera | 0.000542884 | 2 | 2 | BeFree |
Thymoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoma, T-Cell, Cutaneous | 0.000542884 | 2 | 0 | BeFree |
Sicca Syndrome | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Vesicular Stomatitis | 0.000542884 | 2 | 0 | BeFree |
Cancer of Head and Neck | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Oropharyngeal disorders | 0.000542884 | 2 | 0 | BeFree |
Malignant Glioma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
West Nile viral infection | 0.000542884 | 2 | 0 | BeFree |
Neuropathogenesis | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000542884 | 2 | 0 | BeFree |
Triple Negative Breast Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Anemia | 0.000271442 | 1 | 0 | BeFree |
Refractory anaemia with excess blasts | 0.000271442 | 1 | 0 | BeFree |
Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Aortic Rupture | 0.000271442 | 1 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Down Syndrome | 0.000271442 | 1 | 0 | BeFree |
Dwarfism | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Giant Cell Tumors | 0.000271442 | 1 | 0 | BeFree |
Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
IGA Glomerulonephritis | 0.000271442 | 1 | 0 | BeFree |
Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Herpes NOS | 0.000271442 | 1 | 0 | BeFree |
Hypothyroidism | 0.000271442 | 1 | 0 | BeFree |
insulinoma | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Nephritis | 0.000271442 | 1 | 0 | BeFree |
Lymphocytic Choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Monosomy | 0.000271442 | 1 | 0 | BeFree |
Mucocutaneous Lymph Node Syndrome | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Osteomyelitis | 0.000271442 | 1 | 0 | BeFree |
Parainfluenza | 0.000271442 | 1 | 0 | BeFree |
Plasmacytoma | 0.000271442 | 1 | 0 | BeFree |
Rabies (disorder) | 0.000271442 | 1 | 0 | BeFree |
Reoviridae Infections | 0.000271442 | 1 | 0 | BeFree |
Respiratory Tract Infections | 0.000271442 | 1 | 0 | BeFree |
Scleritis | 0.000271442 | 1 | 0 | BeFree |
Cerebrovascular accident | 0.000271442 | 1 | 0 | BeFree |
Synovitis | 0.000271442 | 1 | 0 | BeFree |
Thanatophoric Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
Uveitis | 0.000271442 | 1 | 0 | BeFree |
Varicocele | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Primary Sj�gren's syndrome | 0.000271442 | 1 | 0 | BeFree |
Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
Acute miliary tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Non-arthropod borne lymphocytic choriomeningitis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Abdominal | 0.000271442 | 1 | 0 | BeFree |
Dysplastic Nevus | 0.000271442 | 1 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Diastrophic dysplasia | 0.000271442 | 1 | 0 | BeFree |
Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Atresia | 0.000271442 | 1 | 0 | BeFree |
Disease due to Parvoviridae | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach stage IV | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
stage, neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Stable angina | 0.000271442 | 1 | 0 | BeFree |
Dissection of aorta | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic esophagitis | 0.000271442 | 1 | 0 | BeFree |
Chondrodysplasia | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Skeletal dysplasia | 0.000271442 | 1 | 0 | BeFree |
pricking of skin | 0.000271442 | 1 | 1 | BeFree |
Disseminated due to other mycobacteria | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Chronic active hepatitis | 0.000271442 | 1 | 0 | BeFree |
Carotid Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Carotid Artery Plaque | 0.000271442 | 1 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
Spondylarthritis | 0.000271442 | 1 | 0 | BeFree |
Thanatophoric dysplasia, type 2 | 0.000271442 | 1 | 0 | BeFree |
Anaplastic Large Cell Lymphoma, ALK-Positive | 0.000271442 | 1 | 0 | BeFree |
Invasive Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Systemic onset juvenile chronic arthritis | 0.000271442 | 1 | 0 | BeFree |
Tumor Promotion | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
T-lymphocyte deficiency | 0.000271442 | 1 | 0 | BeFree |
IMMUNE SUPPRESSION | 0.000271442 | 1 | 0 | BeFree |
THANATOPHORIC DYSPLASIA, TYPE I (disorder) | 0.000271442 | 1 | 0 | BeFree |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Juvenile arthritis | 0.000271442 | 1 | 0 | BeFree |
Allergic disposition | 0.000271442 | 1 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000271442 | 1 | 0 | BeFree |
Disseminated Bacillus Calmette-Guerin Infection | 0.000271442 | 1 | 0 | BeFree |
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