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The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是结合许多启动子的富含GC的基序一个锌指转录因子。所编码的蛋白质是参与许多细胞过程,包括细胞分化,细胞生长,细胞凋亡,免疫反应,DNA损伤反应,和染色质重塑。翻译后修饰如磷酸化,乙酰化,糖基化,和蛋白水解加工显著影响该蛋白,它可以是一个活化剂或阻抑物的活性。已发现该基因编码不同亚型三个抄本变形。 [由RefSeq的,2014年11月提供]
SP1基因(以及对应的蛋白质)的细胞分布位置:
SP1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Neoplasm Metastasis | 0.121628651 | 7 | 0 | BeFree_CTD_human |
Neoplastic Cell Transformation | 0.12 | 1 | 0 | CTD_human |
Hyperglycemia | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Skin Neoplasms | 0.12 | 1 | 0 | CTD_human |
Anoxia | 0.013621751 | 5 | 0 | LHGDN |
Colonic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Stomach Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
ovarian neoplasm | 0.0054487 | 2 | 0 | LHGDN |
Mammary Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Alzheimer's Disease | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Glioma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Schizophrenia | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Herpes Simplex Infections | 0.002995792 | 2 | 0 | BeFree_LHGDN |
melanoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Tauopathies | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Cystic Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Ischemia | 0.00272435 | 1 | 0 | LHGDN |
Keratoconus | 0.00272435 | 1 | 0 | LHGDN |
Polycystic Kidney Diseases | 0.00272435 | 1 | 0 | LHGDN |
Myocardial Infarction | 0.00272435 | 1 | 0 | LHGDN |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Familial benign pemphigus | 0.00272435 | 1 | 0 | LHGDN |
Sarcoma | 0.00272435 | 1 | 0 | LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of lung | 0.002714419 | 10 | 0 | BeFree |
Carcinoma of lung | 0.002714419 | 10 | 0 | BeFree |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Pancreatic carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.002171535 | 8 | 0 | BeFree |
Stomach Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001900093 | 7 | 0 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant tumor of cervix | 0.001085767 | 4 | 0 | BeFree |
Osteoporosis | 0.001085767 | 4 | 0 | BeFree |
Cervix carcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Multiple Myeloma | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cerebral Infarction | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Hypercholesterolemia, Familial | 0.000542884 | 2 | 0 | BeFree |
Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Retinoblastoma | 0.000542884 | 2 | 0 | BeFree |
Rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant Pleural Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Cerebral Ischemia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Infection by Cryptococcus neoformans | 0.000271442 | 1 | 0 | BeFree |
Cytomegalovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Fatty Liver | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Graves Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Hyperinsulinism | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Osteoarthritis of hip | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Urinary Stress Incontinence | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of tongue | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Proliferative diabetic retinopathy | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
Chronic schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Cervical Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
stage, ovarian epithelial cancer | 0.000271442 | 1 | 0 | BeFree |
Epiretinal Membrane | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Tongue Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung, stage IV | 0.000271442 | 1 | 0 | BeFree |
Lung cancer stage I | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
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