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This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]
[中文简述(自动翻译):]  该基因编码分拣连接蛋白家族的一个成员。这个家族的成员含有肌醇磷脂结合域,并参与胞内运输。所编码的蛋白质不包含一个卷曲螺旋区域,像一些家族成员,但确实含有靠近其N-末端Src同源结构域。所编码的蛋白质被报道具有多种相互作用配偶,包括衔接蛋白2,dynamin上,酪氨酸激酶非受体2,Wiskott-Aldrich公司综合征样,和ARP3肌动蛋白相关蛋白3所编码的蛋白质在几个牵连细胞内运输,包括内吞,巨吞和F-肌动蛋白的成核阶段。 [由RefSeq的,2013年7月提供]
SNX9基因(以及对应的蛋白质)的细胞分布位置:
SNX9基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Asthma | 0.002367032 | 1 | 0 | GAD |
Hypersensitivity | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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