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Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  突触小泡膜对接和融合由斯耐尔(可溶性N-乙基马来酰亚胺 - 敏感因子附着蛋白受体)位于所述小泡膜(V-SNARE蛋白)和目标膜(叔斯耐尔)介导的。组装V-SNARE /叔SNARE复合由四个螺旋,其中之一是由V-SNARE和其他三个由叔SNARE提供的束的。对质膜叔斯耐尔,所述蛋白质突触用品1螺旋和由该基因编码的蛋白质有利于其他两个。因此,该基因产物是参与神经递质释放的调节突触前质膜蛋白。两种不同的编码蛋白异构体替代转录变异体已经为这个基因描述。 [由RefSeq的,2008年7月提供]
SNAP25基因(以及对应的蛋白质)的细胞分布位置:
SNAP25基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bipolar Disorder | 0.122909916 | 3 | 0 | BeFree_CTD_human_GAD |
Psychotic Disorders | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Depressive disorder | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Experimental | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.12 | 1 | 0 | CTD_human |
Behavioral tic | 0.12 | 1 | 0 | CTD_human |
Neuromuscular Manifestations | 0.12 | 1 | 0 | CTD_human |
Schizophrenia | 0.098088254 | 15 | 4 | BeFree_GAD_LHGDN_MGD |
Attention deficit hyperactivity disorder | 0.046830093 | 40 | 1 | BeFree_GAD |
Tobacco Use Disorder | 0.004734064 | 2 | 0 | GAD |
Weight Gain | 0.004734064 | 2 | 0 | GAD |
Weight Gain Adverse Event | 0.004734064 | 2 | 0 | GAD |
Adenoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Down Syndrome | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Parathyroid Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Prolactinoma | 0.00272435 | 1 | 0 | LHGDN |
Mental Retardation | 0.002638474 | 1 | 0 | BeFree_GAD |
Metabolic Syndrome X | 0.002638474 | 2 | 5 | BeFree_GAD |
As If Personality | 0.002367032 | 1 | 0 | GAD |
Cardiovascular Diseases | 0.002367032 | 1 | 0 | GAD |
Epilepsy | 0.002367032 | 1 | 0 | GAD |
Narcolepsy | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Schizoaffective Disorder | 0.002367032 | 1 | 0 | GAD |
Complications of Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
Congenital ocular coloboma (disorder) | 0.001900093 | 7 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001628651 | 6 | 0 | BeFree |
Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
Mental disorders | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of bladder | 0.001085767 | 4 | 0 | BeFree |
Philadelphia chromosome-positive acute lymphoblastic leukemia | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
Alzheimer's Disease | 0.000542884 | 2 | 0 | BeFree |
Autistic Disorder | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 0 | BeFree |
T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Impaired cognition | 0.000542884 | 2 | 0 | BeFree |
Inattention | 0.000542884 | 2 | 0 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 0 | BeFree |
Autism Spectrum Disorders | 0.000542884 | 2 | 1 | BeFree |
Acute pancreatitis | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Intoxication | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Ataxia | 0.000271442 | 1 | 0 | BeFree |
Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Ataxias, Hereditary | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Fibromyalgia | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Hunger | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Olivopontocerebellar Atrophies | 0.000271442 | 1 | 0 | BeFree |
Oppositional Defiant Disorder | 0.000271442 | 1 | 0 | BeFree |
Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
Alagille Syndrome | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Phototoxic | 0.000271442 | 1 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Pick Disease of the Brain | 0.000271442 | 1 | 0 | BeFree |
Frontotemporal dementia | 0.000271442 | 1 | 0 | BeFree |
Acute alcoholic intoxication | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Frontotemporal Lobar Degeneration | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
Phototoxicity | 0.000271442 | 1 | 0 | BeFree |
NEUROTICISM | 0.000271442 | 1 | 4 | BeFree |
Plaque, Amyloid | 0.000271442 | 1 | 0 | BeFree |
Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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