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This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
[中文简述(自动翻译):]  该基因编码的有机阴离子转运蛋白家族的肝特异性成员。所编码的蛋白质是一种介导许多内源性化合物,包括胆红素,17-β-葡萄糖醛酸雌二醇和白三烯C4的钠依赖性摄取跨膜受体。这种蛋白也参与除去药物化合物,如他汀类,bromosulfophthalein和利福平从血液进入肝细胞。在基因多态性编码此蛋白与受损转运功能相关联。 [由RefSeq的,2009年03月提供]
SLCO1B1基因(以及对应的蛋白质)的细胞分布位置:
SLCO1B1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Rotor Syndrome | 0.240814326 | 3 | 2 | BeFree_CLINVAR_ORPHANET |
Myopathy | 0.136340051 | 25 | 1 | BeFree_CTD_human_GAD_LHGDN |
Chagas Cardiomyopathy | 0.12 | 1 | 1 | GWASCAT |
Adverse reaction to drug | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Hyperbilirubinemia | 0.015621533 | 13 | 0 | BeFree_GAD_LHGDN |
Hyperbilirubinemia, Neonatal | 0.008458305 | 7 | 0 | BeFree_GAD |
Myocardial Infarction | 0.007372538 | 3 | 0 | BeFree_GAD |
Hyperlipidemia | 0.00554839 | 4 | 0 | BeFree_GAD |
Cholelithiasis | 0.005276948 | 2 | 3 | BeFree_GAD |
Cholecystolithiasis | 0.005276948 | 2 | 3 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005005506 | 2 | 0 | BeFree_GAD |
Neutropenia | 0.005005506 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of lung | 0.005005506 | 3 | 0 | BeFree_GAD |
Gilbert Disease (disorder) | 0.004734064 | 2 | 0 | GAD |
HIV Infections | 0.003181358 | 4 | 0 | BeFree_GAD |
Hypercholesterolemia | 0.003181358 | 4 | 1 | BeFree_GAD |
Rheumatoid Arthritis | 0.002909916 | 3 | 0 | BeFree_GAD |
Hypercholesterolemia, Familial | 0.002909916 | 3 | 0 | BeFree_GAD |
Hypertensive disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Tuberculosis | 0.002638474 | 2 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002638474 | 1 | 4 | BeFree_GAD |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.002638474 | 2 | 1 | BeFree_GAD |
Deficiency of glucose-6-phosphate dehydrogenase | 0.002638474 | 2 | 0 | BeFree_GAD |
Arterial Occlusive Diseases | 0.002367032 | 1 | 0 | GAD |
Renal Cell Carcinoma | 0.002367032 | 1 | 0 | GAD |
Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
Gastrointestinal Diseases | 0.002367032 | 1 | 0 | GAD |
Hyperbilirubinemia, Hereditary | 0.002367032 | 1 | 0 | GAD |
Neonatal Jaundice | 0.002367032 | 1 | 0 | GAD |
Kidney Neoplasm | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.001085767 | 4 | 1 | BeFree |
Breast Carcinoma | 0.001085767 | 4 | 1 | BeFree |
Unconjugated hyperbilirubinemia | 0.000814326 | 3 | 0 | BeFree |
Colorectal cancer metastatic | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Primary biliary cirrhosis | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Peptic Ulcer | 0.000542884 | 2 | 0 | BeFree |
Dyslipidemias | 0.000542884 | 2 | 1 | BeFree |
Cholestatic liver disease | 0.000542884 | 2 | 0 | BeFree |
Adenoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Drug Allergy | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000271442 | 1 | 1 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Torsades de Pointes | 0.000271442 | 1 | 0 | BeFree |
Myalgia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Conjugated hyperbilirubinemia | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Bleeding ulcer | 0.000271442 | 1 | 0 | BeFree |
Focal Nodular Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Nephrolithiasis | 0.000271442 | 1 | 0 | BeFree |
Hyperhomocysteinemia | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 2 | BeFree |
Progesterone receptor positive tumor | 0.000271442 | 1 | 2 | BeFree |
Mammographic Density | 0.000271442 | 1 | 0 | BeFree |
Homocysteinemia | 0.000271442 | 1 | 0 | BeFree |
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