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The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是很长链酰基辅酶A合成酶(的VLC)的同工酶。它是能够活化含有非常长链脂肪酸的酸24和26个碳原子的。它是在肝脏表达,与内质网,但不与过氧化物酶有关。它的主要作用是在脂肪酸的伸长或复合脂质合成,而不是在降解。这个基因具有小鼠直向同源物。 [由RefSeq的,2008年7月提供]
SLC27A5基因(以及对应的蛋白质)的细胞分布位置:
SLC27A5基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Fatty Liver | 0.002638474 | 1 | 1 | BeFree_GAD |
Metabolic Syndrome X | 0.002638474 | 1 | 0 | BeFree_GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
Asthma | 0.001628651 | 6 | 0 | BeFree |
HIV Infections | 0.001085767 | 4 | 0 | BeFree |
Pneumonia | 0.000814326 | 3 | 0 | BeFree |
Sarcoidosis | 0.000814326 | 3 | 0 | BeFree |
Pneumonia, Ventilator-Associated | 0.000814326 | 3 | 0 | BeFree |
Chronic Obstructive Airway Disease | 0.000542884 | 2 | 0 | BeFree |
Pulmonary Alveolar Proteinosis | 0.000542884 | 2 | 0 | BeFree |
Sarcoidosis, Pulmonary | 0.000542884 | 2 | 0 | BeFree |
Systemic Scleroderma | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Invasive Pulmonary Aspergillosis | 0.000542884 | 2 | 0 | BeFree |
Non-alcoholic Fatty Liver Disease | 0.000542884 | 2 | 0 | BeFree |
Pneumocystis jiroveci pneumonia | 0.000542884 | 2 | 0 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000542884 | 2 | 0 | BeFree |
Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
Coughing | 0.000271442 | 1 | 0 | BeFree |
Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoproliferative Disorders | 0.000271442 | 1 | 0 | BeFree |
Mycoplasma Infections | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Respiration Disorders | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Wheezing | 0.000271442 | 1 | 0 | BeFree |
Liver Failure | 0.000271442 | 1 | 0 | BeFree |
Liver Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
Lung Diseases, Interstitial | 0.000271442 | 1 | 0 | BeFree |
Simple Pulmonary Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Acute respiratory disease | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Oropharyngeal disorders | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Neutrophilia (disorder) | 0.000271442 | 1 | 0 | BeFree |
Pneumonitis | 0.000271442 | 1 | 0 | BeFree |
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