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The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于钠/胆汁酸协同转运蛋白家族,它们是参与胆汁酸肠肝循环的整合膜糖蛋白。两个同源转运参与胆汁酸的重吸收;与从肠腔,胆管,肾脏和肝特异性钠/胆汁酸协同转运蛋白,由该蛋白质表示吸收胆汁酸的顶端细胞定位回肠钠/胆汁酸协同转运蛋白,即在基底膜发现肝细胞。胆汁酸是胆固醇代谢的代谢产物,因此,这种蛋白质为胆固醇体内平衡很重要。 [由RefSeq的,2011年10月提供]
SLC10A1基因(以及对应的蛋白质)的细胞分布位置:
SLC10A1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hepatitis B | 0.122171535 | 9 | 1 | BeFree_CTD_human |
Liver Cirrhosis, Experimental | 0.12 | 1 | 0 | CTD_human |
Hyperlipidemia | 0.002367032 | 1 | 0 | GAD |
Hyperparathyroidism, Secondary | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
Primary biliary cirrhosis | 0.000814326 | 3 | 0 | BeFree |
Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cholestasis | 0.000542884 | 2 | 0 | BeFree |
Hepatitis D Infection | 0.000542884 | 2 | 0 | BeFree |
Fibrosis, Liver | 0.000542884 | 2 | 0 | BeFree |
Hepatitis B, Chronic | 0.000542884 | 2 | 1 | BeFree |
Hepatitis, Alcoholic | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Xanthomatosis, Cerebrotendinous | 0.000271442 | 1 | 0 | BeFree |
Progressive intrahepatic cholestasis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C, Chronic | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Acute-On-Chronic Liver Failure | 0.000271442 | 1 | 1 | BeFree |
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