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This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
[中文简述(自动翻译):]  该基因编码的肌聚糖家族的一个成员。 Sarcoglycans是在肌营养不良蛋白糖蛋白复合物有助于稳定肌纤维膜和肌肉细胞骨架链接到细胞外基质跨膜组件。在这种基因突变与肢带型肌营养不良症相关联。[通过的RefSeq,2008年10月提供]
SGCB基因(以及对应的蛋白质)的细胞分布位置:
SGCB基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Limb-girdle muscular dystrophy, type 2E | 0.560542884 | 4 | 10 | BeFree_CLINVAR_CTD_human_MGD_ORPHANET_UNIPROT |
Cardiomyopathies | 0.12 | 1 | 0 | CTD_human |
Stomach Carcinoma | 0.025515536 | 94 | 0 | BeFree |
Malignant neoplasm of stomach | 0.021172466 | 78 | 0 | BeFree |
Muscular Dystrophies, Limb-Girdle | 0.009258818 | 7 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.003800186 | 14 | 0 | BeFree |
Gallbladder Carcinoma | 0.002442977 | 9 | 0 | BeFree |
Muscular Dystrophy | 0.001900093 | 7 | 1 | BeFree |
Gastric Adenocarcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of gallbladder | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Sarcoglycanopathies | 0.000814326 | 3 | 0 | BeFree |
Dermatitis verrucosa | 0.000542884 | 2 | 0 | BeFree |
Becker Muscular Dystrophy | 0.000542884 | 2 | 0 | BeFree |
Beta-sarcoglycanopathy | 0.000542884 | 2 | 0 | BeFree |
Adenoid Cystic Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Myopathy | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Agenesis of corpus callosum | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Mucoepidermoid Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Muscle degeneration | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach stage IV | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Torre-Muir syndrome | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
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