更多...
收起
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
[中文简述(自动翻译):]  这个基因编码包含富含半胱氨酸的结构域同源的卷曲蛋白的推定的Wnt结合位点的SFRP家族的一个成员。这个家庭的行为Wnt信号的可溶性调节剂的成员; SFRP基因的后生沉默导致其与癌症相关的的Wnt-途径的失调的活化。此基因也可能是参与确定视网膜感光细胞的极性。 [由RefSeq的,2009年09月提供]
SFRP1基因(以及对应的蛋白质)的细胞分布位置:
SFRP1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.132526052 | 8 | 0 | BeFree_CTD_human_LHGDN |
| Colorectal Neoplasms | 0.125991584 | 6 | 0 | BeFree_CTD_human_LHGDN |
| Fibroid Tumor | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Inflammatory Bowel Diseases | 0.12 | 1 | 0 | CTD_human |
| Renal Cell Carcinoma | 0.012797494 | 7 | 0 | BeFree_LHGDN |
| Bladder Neoplasm | 0.006263026 | 3 | 0 | BeFree_LHGDN |
| Liver neoplasms | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.005971721 | 22 | 0 | BeFree |
| Breast Carcinoma | 0.005971721 | 22 | 0 | BeFree |
| Pancreatic Neoplasm | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Carcinogenesis | 0.004614512 | 17 | 0 | BeFree |
| Neoplasm Metastasis | 0.004353001 | 6 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Glaucoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Barrett Esophagus | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Colorectal Carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Liver carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Osteoporosis | 0.002638474 | 1 | 0 | BeFree_GAD |
| Malignant neoplasm of stomach | 0.002442977 | 9 | 0 | BeFree |
| Stomach Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Colorectal Cancer | 0.002442977 | 9 | 0 | BeFree |
| Asthma | 0.002367032 | 1 | 0 | GAD |
| Bronchial Hyperreactivity | 0.002367032 | 1 | 0 | GAD |
| Adenoma | 0.001357209 | 5 | 0 | BeFree |
| Degenerative polyarthritis | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001357209 | 5 | 0 | BeFree |
| Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.001085767 | 4 | 0 | BeFree |
| Medulloblastoma | 0.001085767 | 4 | 0 | BeFree |
| Carcinoma of bladder | 0.001085767 | 4 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Ulcerative Colitis | 0.000814326 | 3 | 0 | BeFree |
| Meningioma | 0.000814326 | 3 | 0 | BeFree |
| Obesity | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis B | 0.000542884 | 2 | 0 | BeFree |
| Hepatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Keloid | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
| Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
| Adenomatous Polyposis Coli | 0.000542884 | 2 | 0 | BeFree |
| Uterine Fibroids | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
| Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
| Cholangiocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000542884 | 2 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Solid tumour | 0.000542884 | 2 | 0 | BeFree |
| Intraocular pressure disorder | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000542884 | 2 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Plasma Cell | 0.000271442 | 1 | 0 | BeFree |
| Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Monoclonal Gammopathy of Undetermined Significance | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Myopia | 0.000271442 | 1 | 3 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Nodule | 0.000271442 | 1 | 0 | BeFree |
| Obesity, Morbid | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Diseases | 0.000271442 | 1 | 0 | BeFree |
| Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
| Refractive Errors | 0.000271442 | 1 | 3 | BeFree |
| Rheumatism | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Septicemia | 0.000271442 | 1 | 0 | BeFree |
| Synovitis | 0.000271442 | 1 | 0 | BeFree |
| Ureteral obstruction | 0.000271442 | 1 | 0 | BeFree |
| Disorder of the genitourinary system | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Obstructive nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Renal fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Neuroectodermal Tumor, Primitive | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Endometrioid | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Lobular | 0.000271442 | 1 | 0 | BeFree |
| Premature aging syndrome | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sepsis | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
| Cervical Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal cancer recurrent | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| High-Grade Squamous Intraepithelial Lesions | 0.000271442 | 1 | 0 | BeFree |
| Transitional Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis, Knee | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| invasive cancer | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Advanced cancer | 0.000271442 | 1 | 0 | BeFree |
| Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer Model | 0.000271442 | 1 | 0 | BeFree |
| Desmoplastic | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Benign Prostatic Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
| Glucocorticoid Receptor Deficiency | 0.000271442 | 1 | 0 | BeFree |
| Promyelocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Early-Stage Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。