SERPINC1(serpin peptidase inhibitor, clade C (antithrombin), member 1) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1q25.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

[中文简述(自动翻译):]  由该基因编码的蛋白质是一个等离子体蛋白酶抑制剂和丝氨酸蛋白酶抑制剂超家族的成员。这种蛋白抑制凝血酶以及凝血系统的其他活化丝氨酸蛋白酶，它调节凝血级联。该蛋白质包括两个功能域：肝素结合结构域在成熟蛋白质的N末端，在C末端的反应性位点的域。的抑制活性是通过肝素的存在而增强。超过120突变已发现此基因，其中许多已知引起抗凝血酶III缺乏。 [由RefSeq的，2009年7月提供]

OMIM数据库中对SERPINC1基因的介绍     Wikipedia数据库中对SERPINC1基因的介绍

基因序列

基因序列

SERPINC1基因的碱基序列：[NCBI]

基因突变

基因突变

SERPINC1基因的碱基突变：           显示全部snp
rs677       rs5877       rs5878       rs5879       rs941988       rs941989       rs1799876       rs2227586       rs2227587       rs2227588       rs2227589       rs2227590       rs2227591       rs2227592       rs2227593       rs2227594       rs2227595       rs2227596       rs2227597       rs2227598       rs2227599       rs2227600       rs2227601       rs2227602       rs2227603       rs2227604       rs2227605       rs2227606       rs2227607       rs2227608       rs2227609       rs2227610       rs2227611       rs2227612       rs2227613       rs2227614       rs2227615      
rs2227617       rs2227618       rs2227619       rs2227623       rs2227624       rs2227625       rs2227626       rs2227627       rs2227628       rs2759326       rs2759328       rs6695940       rs7523640       rs9425770       rs9661335       rs11582923       rs28929469       rs56288561       rs58759841       rs59197371       rs61736655       rs61827936       rs61827937       rs61827938       rs75549645       rs76343236       rs77439367       rs77518291       rs78050800       rs78407837       rs78704215       rs78972925       rs78983780       rs111304220       rs111676908       rs112071190       rs112212202       rs112250633       rs112933270       rs113244633       rs113396092       rs113650052       rs113885078       rs114896719       rs114906200       rs116763484       rs117717764       rs117858933       rs121909547       rs121909548       rs121909551       rs121909552       rs121909554       rs121909563       rs121909567       rs121909568       rs121909569       rs137976284       rs138286303       rs138511779       rs138541182       rs138949705       rs139148101       rs139213405       rs139275128       rs139308031       rs139392083       rs139463995       rs139866144       rs140271920       rs140452859       rs140616127       rs140695343       rs141516930       rs142294819       rs142619700       rs143033770       rs143083495       rs143319899       rs143447937       rs143521873       rs144084678       rs144618044       rs144659820       rs144688427       rs144797763       rs145355044       rs145418597       rs145617846       rs145771113       rs145928805       rs146128396       rs146146980       rs146692719       rs146733468       rs147249395       rs147266200       rs147655193       rs147676453       rs147973570       rs148086406       rs148518761       rs148783362       rs148886845       rs149006854       rs149806354       rs150335208       rs150478464       rs150507232       rs150866949       rs180676334       rs180933054       rs181384967       rs181464049       rs181483529       rs181559474       rs181666489       rs182562724       rs182885119       rs182919116       rs183110141       rs183380672       rs183416252       rs184472294       rs184508490       rs184793514       rs185290413       rs185878179       rs185999451       rs186131762       rs186210152       rs186261943       rs187022114       rs187162661       rs187249955       rs187520457       rs187826738       rs188274879       rs188341043       rs189183624       rs189278734       rs189522626       rs189550424       rs190231900       rs190396324       rs190674350       rs190691274       rs190843891       rs190912722       rs190933201       rs191146013       rs191604801       rs192187532       rs192448859       rs192819942       rs192921114       rs199469504       rs199525344       rs199528085       rs199895690       rs200118419       rs200460215       rs200550996       rs200810296       rs200857896       rs200861147       rs201173090       rs201381904       rs201411353       rs201551398       rs201656611       rs202085376       rs367854110       rs367876947       rs368106455       rs368419985       rs368902256       rs369524182       rs369828221       rs369894034       rs369954987       rs370190321       rs370576783       rs370818014       rs371099470       rs371222224       rs371722620       rs372319633       rs372611817       rs372820797       rs373264710       rs373515340       rs373637084       rs374205395       rs374256345       rs374763537       rs374909354       rs375038144       rs375346550       rs375773615       rs376029223       rs376328739       rs376752370       rs377120264       rs377500819       rs377588972       rs483352843       rs483352845       rs483352852       rs528945610       rs529055034       rs529574639       rs529615516       rs530087555       rs530403879       rs530504523       rs530812125       rs531051269       rs531137446       rs531513129       rs532036908       rs532353637       rs532413543       rs532490016       rs532846429       rs532883680       rs533547406       rs533612087       rs533612211       rs533624461       rs534220453       rs534233914       rs534357338       rs535257271       rs535328410       rs535340009       rs535756929       rs536180585       rs536252975       rs536280904       rs536361476       rs536431453       rs536867254       rs536875138       rs536880391       rs537225629       rs537706181       rs538156153       rs538161217       rs538259268       rs538275042       rs538609086       rs538671325       rs539168724       rs539868403       rs540158550       rs540248708       rs540487118       rs540730281       rs540742644       rs540782435       rs540970443       rs541308502       rs541549098       rs541773015       rs541849099       rs542120519       rs542300384       rs542350056       rs542738943       rs542749519       rs542881762       rs543358196       rs543634209       rs543777351       rs544713963       rs544724502       rs545134723       rs545196312       rs545228512       rs545304147       rs545558528       rs545702803       rs545766490       rs546277936       rs546292048       rs546677911       rs547112502       rs547319213       rs547365770       rs547815129       rs547845181       rs548294447       rs549281190       rs549417068       rs549644143       rs549908990       rs549921315       rs549991084       rs550247582       rs550803940       rs551126042       rs551166768       rs551279365       rs551575090       rs551665576       rs551687439       rs552064073       rs552439187       rs552714529       rs552826404       rs553705058       rs553846768       rs554029568       rs554282741       rs554287446       rs554349177       rs555006345       rs555419395       rs555617959       rs556155419       rs556217063       rs556328732       rs556359062       rs556664219       rs556827051       rs556993335       rs557080348       rs557242809       rs557344195       rs558146014       rs558321738       rs558551838       rs558662907       rs558670344       rs558726250       rs558860285       rs558961590       rs559263593       rs559277597       rs559552596       rs559850470       rs559911142       rs560112372       rs560226393       rs560516297       rs560610974       rs560623765       rs560651876       rs561043367       rs561060362       rs561959636       rs562367264       rs562639239       rs562683665       rs562879655       rs563074336       rs563293245       rs563362925       rs563691325       rs564406545       rs564608079       rs564783221       rs564949856       rs565026873       rs565091601       rs565276459       rs565387787       rs565506088       rs565546565       rs565866815       rs567202536       rs567255432       rs567550044       rs568047310       rs568570968       rs568574567       rs568637133       rs568742150       rs568956792       rs569659982       rs569728008       rs569799811       rs569840657       rs570016447       rs570129574       rs570305500       rs570949523       rs571595163       rs571661675       rs571861448       rs572077195       rs572252151       rs572313182       rs572709385       rs573543610       rs573589657       rs573631212       rs573643278       rs574138367       rs574448444       rs574508811       rs574547491       rs574561325       rs575049775       rs575474866       rs575625196       rs575822067       rs576111418       rs576231679       rs576282449       rs576549681       rs576581419       rs577103838       rs577409356       rs578203617       rs587776397       rs745357314       rs745578147       rs745583962       rs745698642       rs745890007       rs746232169       rs746402824       rs746429528       rs746430769       rs746504812       rs746961120       rs747142328       rs747288413       rs747412993       rs747558106       rs747641580       rs747977353       rs748072934       rs748251829       rs748278166       rs748428859       rs748553880       rs748774160       rs749037999       rs749129128       rs749308643       rs749510661       rs749583360       rs749848792       rs749956661       rs750413071       rs750607605       rs751112370       rs751357562       rs751704392       rs752241956       rs752544767       rs752730597       rs752818145       rs753056696       rs753196429       rs753254708       rs753390084       rs753408230       rs753713846       rs753725301       rs753759247       rs753863260       rs754390483       rs754917785       rs755045400       rs755808418       rs755827622       rs755838660       rs755986524       rs756016928       rs756267601       rs756459428       rs756940594       rs757009890       rs757200092       rs757611426       rs757851817       rs758045475       rs758087836       rs758115997       rs758316459       rs758603270       rs758698144       rs758801372       rs759002598       rs759050502       rs759275331       rs759369437       rs759583638       rs759734009       rs759821949       rs759854656       rs760408083       rs760952234       rs761024265       rs761436244       rs761729771       rs761918672       rs762004419       rs762291769       rs762356452       rs762780270       rs762965029       rs763052075       rs763087077       rs763400529       rs763486422       rs764115074       rs764313616       rs764338974       rs764455436       rs764606323       rs764695432       rs765121710       rs765204251       rs765287553       rs765445413       rs765632646       rs765761813       rs765797202       rs766277450       rs766334816       rs766626880       rs767005471       rs767159321       rs767187085       rs767468032       rs767683540       rs768121032       rs768646742       rs768704768       rs768914754       rs768953809       rs769120458       rs769761264       rs769820027       rs769991153       rs770098298       rs770200570       rs770218944       rs770330164       rs770381981       rs770580443       rs770852197       rs771146323       rs771347278       rs771520761       rs771696386       rs771712837       rs772040776       rs772089599       rs772515943       rs772686849       rs772710258       rs772807526       rs772809607       rs773134244       rs773254902       rs773309802       rs773399107       rs773688316       rs773751914       rs773792958       rs773814831       rs773822689       rs773947348       rs774262708       rs774294043       rs774393305       rs774506712       rs774632265       rs774744099       rs774877455       rs775062927       rs775397662       rs775413132       rs775520108       rs775538183       rs775845871       rs775919922       rs775997359       rs776257871       rs776277707       rs776344892       rs776662899       rs776785547       rs776791729       rs776992580       rs777118044       rs777327592       rs777405542       rs777418425       rs777786232       rs777886588       rs778100368       rs778165875       rs778341415       rs778650224       rs778745435       rs778896348       rs778915564       rs779025291       rs779121500       rs779331710       rs779790099       rs780062808       rs780549243       rs780670128       rs780733720       rs780821947       rs781308217       rs781696456       rs781733242       rs869255237      

基因表达

基因表达

SERPINC1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AAAGCCAACAAATCCTCCA
58
GACATAGAGGTCATTGAAGGT
57
AAAGCCAACAAATCCTCCA
58
GAGACATAGAGGTCATTGAAGG
58
TACCTTCAATGACCTCTATGTCTC
60
GTACTTGCAGCTGCTTCAC
60
CTGGCAGATTCCAAGAATGAC
59
CTTAAATACCTCCATCAGTTGCTG
60
CCCTGGACTTCAAGGAAGG
60
GTTAACCAGCACCAGAACAG
59
CACCATTTACTTCAAGGGCC
59
TCCATCAGCCTTGTAGAACAG
60
TTCTATCAGCACCTGGCAG
60
CTTAAATACCTCCATCAGTTGCTG
60
TCAGTTTGAAGGAGCAGCT
59
CAACAATACCTGGGAGTTTGG
59
CCCTGGACTTCAAGGAAGG
60
AAATGGTGTTAACCAGCACC
59
CTTCAGTTTGAAGGAGCAGC
60
CAACAATACCTGGGAGTTTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

SERPINC1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

SERPINC1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002020
P01008(UniProtKB)
IPI
GO:0004867
P01008(UniProtKB)
IBA
GO:0004867
P01008(UniProtKB)
NAS
GO:0005515
P01008(UniProtKB)
IPI
GO:0005576
P01008(UniProtKB)
NAS
GO:0005576
P01008(UniProtKB)
TAS
GO:0005576
P01008(UniProtKB)
TAS
GO:0005615
P01008(UniProtKB)
IDA
GO:0005615
P01008(UniProtKB)
IDA
GO:0005886
P01008(UniProtKB)
TAS
GO:0005886
P01008(UniProtKB)
TAS
GO:0005886
P01008(UniProtKB)
TAS
GO:0005886
P01008(UniProtKB)
TAS
GO:0007584
P01008(UniProtKB)
IEA
GO:0007596
P01008(UniProtKB)
TAS
GO:0008201
P01008(UniProtKB)
IEA
GO:0010951
P01008(UniProtKB)
IEA
GO:0050728
P01008(UniProtKB)
IEA
GO:0070062
P01008(UniProtKB)
IDA
GO:0070062
P01008(UniProtKB)
IDA
GO:0072562
P01008(UniProtKB)
IDA
GO:2000266
P01008(UniProtKB)
IEA
GO:0004867
Q8TCE1(UniProtKB)
IEA
GO:0005615
Q8TCE1(UniProtKB)
IEA
GO:0008201
Q8TCE1(UniProtKB)
IEA
GO:0010951
Q8TCE1(UniProtKB)
IEA
GO:2000266
Q8TCE1(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控SERPINC1基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Antithrombin III Deficiency 0.568805692 45 32 BeFree_CLINVAR_CTD_human_GAD_MGD_ORPHANET_UNIPROT
Venous Thrombosis 0.142732561 12 1 CTD_human_GAD_LHGDN
Thrombosis 0.125091382 6 0 CTD_human_GAD_LHGDN
Venous Thromboembolism 0.122367032 2 0 CTD_human_GAD
Blood Coagulation Disorders 0.120542884 3 0 BeFree_CTD_human
Disseminated Intravascular Coagulation 0.120271442 4 0 BeFree_CTD_human
Nephrotic Syndrome 0.12 1 0 CTD_human
Respiratory Distress Syndrome, Adult 0.12 1 0 CTD_human
Liver Failure, Acute 0.12 1 0 CTD_human
Intracranial Thrombosis 0.12 1 0 CTD_human
Acute Coronary Syndrome 0.12 1 0 CTD_human
Cerebral Hemorrhage 0.12 1 0 CTD_human
Icterus 0.08 1 0 RGD
Endotoxemia 0.08 2 0 RGD
Thrombophilia 0.007719925 13 1 BeFree_GAD
Thromboembolism 0.004810009 10 0 BeFree_GAD
Activated Protein C Resistance 0.004071628 15 1 BeFree
Protein S Deficiency 0.002985861 11 0 BeFree
THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) 0.002985861 11 1 BeFree
Cerebral Infarction 0.002909916 3 0 BeFree_GAD
Renal hypertension 0.00272435 1 0 LHGDN
Lymphoma 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Renal Artery Obstruction 0.00272435 1 0 LHGDN
Hypertensive disease 0.002638474 2 0 BeFree_GAD
Lupus anticoagulant disorder 0.002442977 9 1 BeFree
Alzheimer's Disease 0.002367032 1 0 GAD
Chorioamnionitis 0.002367032 1 0 GAD
Coronary Thrombosis 0.002367032 1 0 GAD
Fetal Membranes, Premature Rupture 0.002367032 1 0 GAD
Premature Obstetric Labor 0.002367032 1 0 GAD
Myocardial Infarction 0.002367032 1 0 GAD
Pre-Eclampsia 0.002367032 1 0 GAD
Premature Birth 0.002367032 1 0 GAD
Pregnancy loss 0.002367032 1 0 GAD
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 0.002367032 1 0 GAD
Factor V Leiden mutation 0.001900093 7 0 BeFree
Congenital Abnormality 0.001628651 6 0 BeFree
Deep Vein Thrombosis 0.001628651 6 3 BeFree
Hereditary Antithrombin Deficiency 0.001628651 6 1 BeFree
Protein C Deficiency 0.001357209 5 0 BeFree
Ischemic stroke 0.001085767 4 0 BeFree
Ischemic Cerebrovascular Accident 0.001085767 4 0 BeFree
Pulmonary Embolism 0.000814326 3 0 BeFree
Cerebrovascular accident 0.000814326 3 0 BeFree
Deep vein thrombosis of lower limb 0.000814326 3 0 BeFree
Hypoplasminogenemia 0.000814326 3 0 BeFree
Liver carcinoma 0.000814326 3 0 BeFree
Coronary heart disease 0.000542884 2 0 BeFree
Homocystinuria 0.000542884 2 0 BeFree
Liver neoplasms 0.000542884 2 0 BeFree
Thrombophlebitis 0.000542884 2 0 BeFree
Deep thrombophlebitis 0.000542884 2 3 BeFree
Malnutrition 0.000542884 2 0 BeFree
ANTITHROMBIN III DEFICIENCY, FAMILIAL 0.000542884 2 0 BeFree
Mesenteric Venous Thrombosis 0.000542884 2 0 BeFree
Cerebral venous sinus thrombosis 0.000542884 2 0 BeFree
Homocysteinemia 0.000542884 2 0 BeFree
Amyloidosis 0.000271442 1 0 BeFree
Aplastic Anemia 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Atherosclerosis 0.000271442 1 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Charcot-Marie-Tooth Disease 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetes Mellitus, Insulin-Dependent 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Esophageal Neoplasms 0.000271442 1 0 BeFree
Hepatic Vein Thrombosis 0.000271442 1 0 BeFree
Kidney Diseases 0.000271442 1 0 BeFree
Legg-Calve-Perthes Disease 0.000271442 1 0 BeFree
Acute lymphocytic leukemia 0.000271442 1 0 BeFree
Leukemia, Lymphocytic, Acute, L1 0.000271442 1 0 BeFree
Lupus Vulgaris 0.000271442 1 0 BeFree
Lupus Erythematosus, Discoid 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Paroxysmal nocturnal hemoglobinuria 0.000271442 1 0 BeFree
Degenerative polyarthritis 0.000271442 1 0 BeFree
Polycystic Ovary Syndrome 0.000271442 1 0 BeFree
Retinal Diseases 0.000271442 1 0 BeFree
Supraventricular tachycardia 0.000271442 1 0 BeFree
Cerebral Thrombosis 0.000271442 1 0 BeFree
Neurofibrillary degeneration (morphologic abnormality) 0.000271442 1 0 BeFree
Essential Hypertension 0.000271442 1 0 BeFree
Esophageal carcinoma 0.000271442 1 0 BeFree
anticoagulant disorders 0.000271442 1 0 BeFree
Liver and Intrahepatic Biliary Tract Carcinoma 0.000271442 1 0 BeFree
Malignant neoplasm of liver 0.000271442 1 0 BeFree
Lupus Erythematosus 0.000271442 1 0 BeFree
Malignant neoplasm of esophagus 0.000271442 1 0 BeFree
Hypofibrinogenemia 0.000271442 1 0 BeFree
Central nervous system lymphoma 0.000271442 1 0 BeFree
Budd-Chiari Syndrome 0.000271442 1 0 BeFree
Sarcoma 0.000271442 1 0 BeFree
Tumor-Associated Vasculature 0.000271442 1 0 BeFree
Congenital disorder of glycosylation type 1B 0.000271442 1 0 BeFree
Parvovirus B19 (disease) 0.000271442 1 0 BeFree
Prothrombin G20210A mutation 0.000271442 1 0 BeFree
Hereditary antithrombin III deficiency 0.000271442 1 0 BeFree
Plaque, Amyloid 0.000271442 1 0 BeFree

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