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The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是相似的酵母Sec31蛋白。酵母Sec31蛋白已知是COPII蛋白复合物,它负责囊泡从内质网(ER)出芽的一个组件。这种蛋白质被发现与SEC13,COPII的其它部件中的一个来共定位,在相应于小泡运输功能的亚细胞结构。一个免疫耗竭实验证实,该蛋白质是必需的ER-高尔基体运输。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的,2008年7月提供]
SEC31A基因(以及对应的蛋白质)的细胞分布位置:
SEC31A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diffuse Large B-Cell Lymphoma | 0.12 | 1 | 0 | CTD_human |
Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Inflammatory Myofibroblastic Tumor | 0.000271442 | 1 | 0 | BeFree |
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