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The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质被初步确定为聚糖介导的信号链接至细胞骨架的分子。该syntenin蛋白含有串联重复结合各种跨膜蛋白的胞质,C端结构域PDZ结构域。这种蛋白也可能影响细胞骨架 - 膜组织,细胞粘附,蛋白质运输,和转录因子的活化。该蛋白质主要定位于膜相关粘着结和粘着斑但在内质网和核中也有发现。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的,2008年7月提供]
SDCBP基因(以及对应的蛋白质)的细胞分布位置:
SDCBP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Degenerative polyarthritis | 0.12 | 1 | 0 | CTD_human |
Neoplasm Metastasis | 0.008163119 | 12 | 0 | BeFree_LHGDN |
melanoma | 0.005710211 | 12 | 0 | BeFree_LHGDN |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Metastatic melanoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Uveal melanoma | 0.000271442 | 1 | 0 | BeFree |
edema disease | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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