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The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一种跨膜(I型)硫酸乙酰肝素蛋白多糖,并且是聚糖蛋白聚糖家族中的一员。所述syndecans介导的细胞结合,细胞信号传导和细胞骨架组织和聚糖受体所需的HIV-1的Tat蛋白的内化。该多配体聚糖-1蛋白作为完整的膜蛋白,并通过其细胞外基质蛋白受体参与细胞增殖,细胞迁移和细胞 - 基质相互作用。改变聚糖-1的表达已经在几个不同的肿瘤类型被检测到。而几个转录变异体可能存在于该基因,只有两个全长性质已经描述到日期。这两个代表该基因的主要变体和编码相同蛋白。 [由RefSeq的,2008年7月提供]
SDC1基因(以及对应的蛋白质)的细胞分布位置:
SDC1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Obesity | 0.080271442 | 2 | 0 | BeFree_RGD |
| Hyperlipidemia | 0.08 | 1 | 0 | RGD |
| Inflammation | 0.08 | 1 | 0 | RGD |
| Myocardial Infarction | 0.08 | 1 | 0 | RGD |
| Proteinuria | 0.08 | 1 | 0 | RGD |
| Multiple Myeloma | 0.030411421 | 102 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.011168843 | 5 | 0 | BeFree_LHGDN |
| Neoplasm Metastasis | 0.005981653 | 12 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.005167327 | 9 | 0 | BeFree_LHGDN |
| Breast Carcinoma | 0.004614512 | 17 | 0 | BeFree |
| Malignant neoplasm of breast | 0.00434307 | 16 | 0 | BeFree |
| B-Cell Lymphomas | 0.003810118 | 5 | 0 | BeFree_LHGDN |
| Liver carcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
| Glioma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Chronic Lymphocytic Leukemia | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Colorectal Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Immunoproliferative Small Intestinal Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Pancreatic Neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Psoriasis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| ovarian neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Endometrial Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Mouth Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Carcinogenesis | 0.002714419 | 10 | 0 | BeFree |
| Monoclonal Gammopathy of Undetermined Significance | 0.002442977 | 9 | 0 | BeFree |
| Lymphoma | 0.001900093 | 7 | 0 | BeFree |
| Adenocarcinoma | 0.001628651 | 6 | 0 | BeFree |
| Colorectal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
| Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
| Colitis | 0.000814326 | 3 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
| Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000542884 | 2 | 0 | BeFree |
| Congenital chromosomal disease | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Lymphoma, Follicular | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000542884 | 2 | 0 | BeFree |
| Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
| Nasal Polyps | 0.000542884 | 2 | 0 | BeFree |
| Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
| Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
| Immunoblastic Large-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Polymyositis | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm, Residual | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Nephrolithiasis | 0.000542884 | 2 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Primary Effusion Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Invasive Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Tumor Angiogenesis | 0.000542884 | 2 | 0 | BeFree |
| Smoldering myeloma | 0.000542884 | 2 | 0 | BeFree |
| MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.000542884 | 2 | 0 | BeFree |
| Plasmablastic lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Amyloidosis | 0.000271442 | 1 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Bladder Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Bone Diseases | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
| Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
| Common Variable Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
| Adenoid Cystic Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cyst | 0.000271442 | 1 | 0 | BeFree |
| Endometriosis | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| Hyperphagia | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
| Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Lipoma | 0.000271442 | 1 | 0 | BeFree |
| liposarcoma | 0.000271442 | 1 | 0 | BeFree |
| Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Malaria | 0.000271442 | 1 | 0 | BeFree |
| Measles | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Myoepithelioma | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Optic Neuritis | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Papilloma | 0.000271442 | 1 | 0 | BeFree |
| Peritonitis | 0.000271442 | 1 | 0 | BeFree |
| Plasmacytoma | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Gastric ulcer | 0.000271442 | 1 | 0 | BeFree |
| Subacute Sclerosing Panencephalitis | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Atrophic condition of skin | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Liposarcoma, Dedifferentiated | 0.000271442 | 1 | 0 | BeFree |
| Myelolipoma | 0.000271442 | 1 | 0 | BeFree |
| Inclusion Body Myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Tuberculosis of intestines | 0.000271442 | 1 | 0 | BeFree |
| Cervical Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
| Solid tumour | 0.000271442 | 1 | 0 | BeFree |
| MYELOMA, ENDOTHELIAL | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Post-transplant lymphoproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gastrointestinal tract | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Corneal infection | 0.000271442 | 1 | 0 | BeFree |
| Ovarian adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Papillomavirus Infections | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Epithelioma | 0.000271442 | 1 | 0 | BeFree |
| Malignant Conversion | 0.000271442 | 1 | 0 | BeFree |
| Skin Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Primary cutaneous large B-cell lymphoma of the leg | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
| Plasma Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Clinically isolated syndrome | 0.000271442 | 1 | 0 | BeFree |
| Immunoglobulin a deficiency 1 | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Lipomatosis, Multiple | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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