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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是S100家族含有2 EF手钙结合基序的蛋白质的成员。 S100蛋白是局部在广泛的细胞的细胞质和/或细胞核,并参与了许多细胞过程的调控,如细胞周期进程和分化。 S100基因包括至少13名成员分别位于作为染色体1q21集群;然而,该基因位于21q22.3。这种蛋白可以以轴突延伸,黑色素瘤细胞,钙离子通量的刺激,抑制蛋白激酶C介导的磷酸化,星形细胞和轴突增殖,微管组装的抑制增殖的作用。染色体重排和该基因的改变的表达有牵连几种神经学,肿瘤,和其他类型的疾病,包括阿尔茨海默氏病,唐氏综合征,癫痫症,肌萎缩性侧索硬化症,黑素瘤,和I型糖尿病。 [由RefSeq的,2008年7月提供]
S100B基因(以及对应的蛋白质)的细胞分布位置:
S100B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bipolar Disorder | 0.203181358 | 5 | 0 | BeFree_CTD_human_GAD_RGD |
Myocardial Infarction | 0.201357209 | 5 | 0 | BeFree_CTD_human_RGD |
Hematoma | 0.2 | 2 | 0 | CTD_human_RGD |
Brain Edema | 0.2 | 2 | 0 | CTD_human_RGD |
Down Syndrome | 0.129248887 | 16 | 0 | BeFree_CTD_human_LHGDN |
Cerebral Hemorrhage | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
Attention Deficit and Disruptive Behavior Disorders | 0.12 | 1 | 0 | CTD_human |
Vasospasm, Intracranial | 0.12 | 1 | 0 | CTD_human |
Alzheimer's Disease | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
Cerebrovascular accident | 0.083267234 | 4 | 0 | BeFree_LHGDN_RGD |
Brain Ischemia | 0.08272435 | 2 | 0 | LHGDN_RGD |
Seizures | 0.08272435 | 2 | 0 | LHGDN_RGD |
Depressive disorder | 0.081085767 | 5 | 2 | BeFree_RGD |
Bladder Neoplasm | 0.080542884 | 2 | 0 | BeFree_RGD |
Borna Disease | 0.08 | 1 | 0 | RGD |
Demyelinating Diseases | 0.08 | 1 | 0 | RGD |
Dental Pulp Exposure | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 2 | 0 | RGD |
Epilepsy | 0.08 | 1 | 0 | RGD |
Hypotension | 0.08 | 1 | 0 | RGD |
Myocardial Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Sleep Apnea Syndromes | 0.08 | 1 | 0 | RGD |
HIV Infections | 0.043159258 | 159 | 2 | BeFree |
melanoma | 0.021212192 | 42 | 0 | BeFree_LHGDN |
Schizophrenia | 0.010801593 | 12 | 0 | BeFree_GAD_LHGDN |
Neoplasm Metastasis | 0.009781839 | 27 | 0 | BeFree_LHGDN |
Brain Diseases | 0.005991584 | 3 | 0 | BeFree_LHGDN |
Fetal Growth Retardation | 0.0054487 | 2 | 0 | LHGDN |
Inflammation | 0.0054487 | 2 | 0 | LHGDN |
Psoriasis | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Ischemia | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Dementia | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Mental disorders | 0.003181358 | 4 | 0 | BeFree_GAD |
Celiac Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Meningioma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Mood Disorders | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Breast Carcinoma | 0.002985861 | 11 | 0 | BeFree |
Major Depressive Disorder | 0.002909916 | 2 | 1 | BeFree_GAD |
Anorexia Nervosa | 0.00272435 | 1 | 0 | LHGDN |
Gliosis | 0.00272435 | 1 | 0 | LHGDN |
Hepatic Encephalopathy | 0.00272435 | 1 | 0 | LHGDN |
Hepatitis | 0.00272435 | 1 | 0 | LHGDN |
Lupus Erythematosus, Systemic | 0.00272435 | 1 | 0 | LHGDN |
Neural Tube Defects | 0.00272435 | 1 | 0 | LHGDN |
Pre-Eclampsia | 0.00272435 | 1 | 0 | LHGDN |
Compression of spinal cord | 0.00272435 | 1 | 0 | LHGDN |
Hypoplastic Left Heart Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Atrophic | 0.00272435 | 1 | 0 | LHGDN |
Spinal Cord Ischemia | 0.00272435 | 1 | 0 | LHGDN |
Infection | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Tumor Progression | 0.002171535 | 8 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001628651 | 6 | 0 | BeFree |
Neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
Stomach Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.001628651 | 6 | 0 | BeFree |
Adenocarcinoma | 0.001357209 | 5 | 0 | BeFree |
Glioma | 0.001357209 | 5 | 0 | BeFree |
Neurilemmoma | 0.001357209 | 5 | 0 | BeFree |
Virus Diseases | 0.001357209 | 5 | 0 | BeFree |
Metastatic melanoma | 0.001357209 | 5 | 0 | BeFree |
Central neuroblastoma | 0.001357209 | 5 | 0 | BeFree |
EPIDERMAL DIFFERENTIATION COMPLEX | 0.001357209 | 5 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Mental Depression | 0.001085767 | 4 | 2 | BeFree |
Microphthalmos | 0.001085767 | 4 | 0 | BeFree |
neurofibroma | 0.001085767 | 4 | 0 | BeFree |
Senile Plaques | 0.001085767 | 4 | 0 | BeFree |
Plaque, Amyloid | 0.001085767 | 4 | 0 | BeFree |
Rheumatoid Arthritis | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
Ulcerative Colitis | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
Sinus histiocytosis | 0.000814326 | 3 | 0 | BeFree |
Nerve Sheath Tumors | 0.000814326 | 3 | 0 | BeFree |
Neurodegenerative Disorders | 0.000814326 | 3 | 0 | BeFree |
Ewings sarcoma | 0.000814326 | 3 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
Cardiomyopathies | 0.000814326 | 3 | 0 | BeFree |
Desmoplastic melanoma | 0.000814326 | 3 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 2 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 1 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 4 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 5 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 6 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 7 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 8 | 0.000814326 | 3 | 1 | BeFree |
MAJOR AFFECTIVE DISORDER 9 | 0.000814326 | 3 | 1 | BeFree |
Acquired Immunodeficiency Syndrome | 0.000542884 | 2 | 0 | BeFree |
Amyloidosis | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Chondroblastoma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenoid Cystic Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Presenile dementia | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoproliferative Disorders | 0.000542884 | 2 | 0 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Neurofibromatosis 1 | 0.000542884 | 2 | 0 | BeFree |
Nodule | 0.000542884 | 2 | 0 | BeFree |
Degenerative polyarthritis | 0.000542884 | 2 | 0 | BeFree |
Psychotic Disorders | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 1 | BeFree |
Vascular Diseases | 0.000542884 | 2 | 0 | BeFree |
T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Granular cell tumor | 0.000542884 | 2 | 0 | BeFree |
Cutaneous Melanoma | 0.000542884 | 2 | 0 | BeFree |
Sarcoma, Clear Cell | 0.000542884 | 2 | 0 | BeFree |
Acinar Cell Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Ganglioneuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Plexiform Neurofibroma | 0.000542884 | 2 | 0 | BeFree |
Metastatic malignant neoplasm to brain | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
pediatric AIDS | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 0 | BeFree |
stage, non-small cell lung cancer | 0.000542884 | 2 | 0 | BeFree |
Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Dermatofibrosarcoma Protuberans | 0.000542884 | 2 | 0 | BeFree |
hiv-infection/aids | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
Acute Cerebrovascular Accidents | 0.000542884 | 2 | 0 | BeFree |
Acute schizophrenia | 0.000542884 | 2 | 0 | BeFree |
Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Solitary fibrous tumor | 0.000542884 | 2 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Spindle Cell Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Epithelioma | 0.000542884 | 2 | 0 | BeFree |
Acquired CJD | 0.000542884 | 2 | 0 | BeFree |
AIDS Dementia Complex | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Aspergillosis | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Candidiasis | 0.000271442 | 1 | 0 | BeFree |
Candidiasis of vagina | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Transitional Cell | 0.000271442 | 1 | 0 | BeFree |
Chest Pain | 0.000271442 | 1 | 0 | BeFree |
Craniosynostosis | 0.000271442 | 1 | 0 | BeFree |
Dental caries | 0.000271442 | 1 | 0 | BeFree |
Dry Eye Syndromes | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Ependymoma | 0.000271442 | 1 | 0 | BeFree |
Ganglioneuroma | 0.000271442 | 1 | 0 | BeFree |
Graves Disease | 0.000271442 | 1 | 0 | BeFree |
Heart failure | 0.000271442 | 1 | 0 | BeFree |
Congestive heart failure | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
Hepatosplenomegaly | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Mycoses | 0.000271442 | 1 | 0 | BeFree |
Myoepithelioma | 0.000271442 | 1 | 0 | BeFree |
Neuroma | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Familial Mediterranean Fever | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Paranoid Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Thyroid Diseases | 0.000271442 | 1 | 0 | BeFree |
Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
von Willebrand Disease | 0.000271442 | 1 | 0 | BeFree |
Adenosis of Breast | 0.000271442 | 1 | 0 | BeFree |
Codependency | 0.000271442 | 1 | 0 | BeFree |
Chronic sinusitis | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Neuroectodermal Tumors | 0.000271442 | 1 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000271442 | 1 | 0 | BeFree |
Ganglioglioma | 0.000271442 | 1 | 0 | BeFree |
Comedone | 0.000271442 | 1 | 0 | BeFree |
Chondromyxoid fibroma | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
invasive aspergillosis | 0.000271442 | 1 | 0 | BeFree |
Fibrous Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Classical galactosemia | 0.000271442 | 1 | 0 | BeFree |
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 0.000271442 | 1 | 0 | BeFree |
Myomatous neoplasm | 0.000271442 | 1 | 0 | BeFree |
Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
Dryness of eye | 0.000271442 | 1 | 0 | BeFree |
Caries (morphologic abnormality) | 0.000271442 | 1 | 0 | BeFree |
Secretory breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant desmoplastic melanoma | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Indeterminate colitis | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic human immunodeficiency virus infection | 0.000271442 | 1 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant melanoma of choroid | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Dyslexia | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
CNS metastases | 0.000271442 | 1 | 0 | BeFree |
Candidiasis, Vulvovaginal | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Spinocerebellar Ataxia Type 1 | 0.000271442 | 1 | 0 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
social stress | 0.000271442 | 1 | 0 | BeFree |
Erdheim-Chester Disease | 0.000271442 | 1 | 0 | BeFree |
Developmental reading disorder | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Polymorphous low grade adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Parachordoma | 0.000271442 | 1 | 0 | BeFree |
Extraskeletal Myxoid Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Meibomian gland dysfunction | 0.000271442 | 1 | 0 | BeFree |
Single tumor | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Sclerosing Hemangioma | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary Lesion | 0.000271442 | 1 | 0 | BeFree |
Vascular lesions | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
Osteofibrous Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | 0.000271442 | 1 | 0 | BeFree |
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