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This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的细菌RuvB基因的第二人类同源。细菌RuvB蛋白质是DNA解旋酶用于同源重组和DNA双链断裂修复是必不可少的。功能分析表明,该基因的产物既具有ATP酶和DNA解旋酶活性。这种基因是物理连接到染色体19q13.3的CGB / LHB基因簇,并且是非常接近(55 nt)的至LHB基因,在相反的方向。 [由RefSeq的,2008年7月提供]
RUVBL2基因(以及对应的蛋白质)的细胞分布位置:
RUVBL2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Cerebrovascular accident | 0.004734064 | 2 | 0 | GAD |
| Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
| Subarachnoid Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Intracranial Hemorrhages | 0.002367032 | 1 | 0 | GAD |
| Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
| Ischemic stroke | 0.000542884 | 2 | 5 | BeFree |
| Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Ischemic Cerebrovascular Accident | 0.000542884 | 2 | 5 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
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