RRM2(ribonucleotide reductase M2) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

2p25-p24
基因染色体位置图

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

[中文简述(自动翻译):]  这个基因编码的两个非相同的亚基为核苷酸还原酶之一。此还原酶催化脱氧核糖核苷酸从核糖核苷酸的形成。所编码的蛋白质(M2)的合成在细胞周期依赖的方式被限制。从该基因转录可以从替代的启动子,这导致在其N-末端的长度不同的两种同种型启动。相关假已经确定在[由RefSeq的,2009年9月提供]染色体1和X.

RRM2基因的碱基序列:[NCBI]
RRM2基因的碱基突变:           显示全部snp
rs15516       rs1130609       rs1138729       rs4668664       rs5030743       rs5030757       rs5030759       rs5030760       rs6432065       rs6737932       rs6741290       rs6746634       rs6759180       rs7577557       rs7577887       rs7582263       rs7603436       rs10178011       rs11545186       rs11545188       rs11681986       rs11688552       rs13400205       rs34217469       rs34237683       rs61754180       rs61754475       rs62129881       rs62129882       rs62129883       rs68002429       rs71437694       rs72542773       rs72542774       rs72542775       rs72542776       rs72542777      
rs72542779       rs72542780       rs72542781       rs72542782       rs72542783       rs72542784       rs72542785       rs72542786       rs72542787       rs72542788       rs72542789       rs72542790       rs72542791       rs72542792       rs72542793       rs72542794       rs72542795       rs72542796       rs72544297       rs72544298       rs72544299       rs72544300       rs72786664       rs74918071       rs75249934       rs75858047       rs75955595       rs76038995       rs76515542       rs77323676       rs77551478       rs78311808       rs79162203       rs79765591       rs79994803       rs112169984       rs113313134       rs113341858       rs114005347       rs114117370       rs114571498       rs114584653       rs114690291       rs115318989       rs115637599       rs115740885       rs115966142       rs116557757       rs116561970       rs116696933       rs117899968       rs138102168       rs138601776       rs138652606       rs139359585       rs139954791       rs140034020       rs140094271       rs140269701       rs141284388       rs141926508       rs141995155       rs142240748       rs142631876       rs142748265       rs142939100       rs143568890       rs143710525       rs144621246       rs144948625       rs145536953       rs145863886       rs145875300       rs146049035       rs146636930       rs146940804       rs147566577       rs147651077       rs148236267       rs148505225       rs148559555       rs148740312       rs148818815       rs148853193       rs148870651       rs149311892       rs150059735       rs150375246       rs150662887       rs150889173       rs151112936       rs181250474       rs181447519       rs181847840       rs182467300       rs182776618       rs182957125       rs182990256       rs183775689       rs184015149       rs184168016       rs184696021       rs185545160       rs185874295       rs186028912       rs186654277       rs187152798       rs187349869       rs187569312       rs188323526       rs188592031       rs189116553       rs189129962       rs190435090       rs190501818       rs190767443       rs191054082       rs191269083       rs191919155       rs192510398       rs192657663       rs192758317       rs193178899       rs199673606       rs200163548       rs200259620       rs200889433       rs202052437       rs202195880       rs367602479       rs368001878       rs368006881       rs368258193       rs368378629       rs368733573       rs369440579       rs369486626       rs369488948       rs369537395       rs369652501       rs369824768       rs370125026       rs370283179       rs370295524       rs370441956       rs370799457       rs370831080       rs370916156       rs371198441       rs371603045       rs371772699       rs372500427       rs372732546       rs373151401       rs373190446       rs373196837       rs373279736       rs374107868       rs374479240       rs374811810       rs375182199       rs375249597       rs375643356       rs375806967       rs376320896       rs376404486       rs376458388       rs377527927       rs528009166       rs529130526       rs529305764       rs529769226       rs530344462       rs530374018       rs530508202       rs530846614       rs531048106       rs531583370       rs531969479       rs532030581       rs533155234       rs533215835       rs533843695       rs533905644       rs534137052       rs534254567       rs534347219       rs534610811       rs535074966       rs535628678       rs535862183       rs535923889       rs536175549       rs536433842       rs536716140       rs536850291       rs536907118       rs537441059       rs537702311       rs538123832       rs538183732       rs539045567       rs539172555       rs539319390       rs539384881       rs539909033       rs540435626       rs541289255       rs541462545       rs541876326       rs542410399       rs542720330       rs543009939       rs543162257       rs543262157       rs543808315       rs544286768       rs545306582       rs545366450       rs545368074       rs546566518       rs547511857       rs547619130       rs547688813       rs548047508       rs548641551       rs549047562       rs549536921       rs549589878       rs549895894       rs550131020       rs550358516       rs550435577       rs550518110       rs551367954       rs551558651       rs551574367       rs551624348       rs551639029       rs551699872       rs551776154       rs552621593       rs552702025       rs552809280       rs553442939       rs553879058       rs554292811       rs554679879       rs554847023       rs554909860       rs555064056       rs555440595       rs555847408       rs555962514       rs556628299       rs556674790       rs556689737       rs557670968       rs557947933       rs558730176       rs558883655       rs558946103       rs559010900       rs559073232       rs560015986       rs560570626       rs561023083       rs561698013       rs562648012       rs562711576       rs562932559       rs562974254       rs563228348       rs564170030       rs565233564       rs566052230       rs566189274       rs567134388       rs567302711       rs567314807       rs567808412       rs568408841       rs568926328       rs569078612       rs569141822       rs569278922       rs569517467       rs569661738       rs570106471       rs570168023       rs570415424       rs570480329       rs571301633       rs571493629       rs571610050       rs572272890       rs572458058       rs573414501       rs574555188       rs574618187       rs574667927       rs574906421       rs575302479       rs575474308       rs575729163       rs575899959       rs576421692       rs577739104       rs577801299       rs577803252       rs578112183       rs745343301       rs745490354       rs745543546       rs745642885       rs745863235       rs746201114       rs746378529       rs746482824       rs746858492       rs747010999       rs747028003       rs747257115       rs747349610       rs747585709       rs747934640       rs747985105       rs747997170       rs748059332       rs748130919       rs748196196       rs748239243       rs748332244       rs748539978       rs748663501       rs748712181       rs748880905       rs749005405       rs749060558       rs749187793       rs749330662       rs749460609       rs749647333       rs749951992       rs750055434       rs750203926       rs750330383       rs750335131       rs750443365       rs750565489       rs750609583       rs750664283       rs750985058       rs751101002       rs751173166       rs751228179       rs751351052       rs751585651       rs751684143       rs752109884       rs752116944       rs752296530       rs752351318       rs752509850       rs752527099       rs753051349       rs753054700       rs753276719       rs753434207       rs753472432       rs753756989       rs753828702       rs754061118       rs754200493       rs754253633       rs754613771       rs754666634       rs754946173       rs754992349       rs755425319       rs755484474       rs755828575       rs755979573       rs756160466       rs756315194       rs756329006       rs756364571       rs756520918       rs756637379       rs756710024       rs756737139       rs756826329       rs756946380       rs756979536       rs757029932       rs757200471       rs757409672       rs757410902       rs757514364       rs757742362       rs758005746       rs758044134       rs758099243       rs758123078       rs758243071       rs758491360       rs758538536       rs758707829       rs758964711       rs759062029       rs759068332       rs759347499       rs759402515       rs759527225       rs759707613       rs759762086       rs759894096       rs760155592       rs760437214       rs760494607       rs760561877       rs760575477       rs760734395       rs760863372       rs761047982       rs761101278       rs761298189       rs761441887       rs761501615       rs761628271       rs761749812       rs762056233       rs762107853       rs762191202       rs762242367       rs762576156       rs762629128       rs762751904       rs763179976       rs763302312       rs763568241       rs763595587       rs763796541       rs764199311       rs764452044       rs764902245       rs764915268       rs765011415       rs765066771       rs765428474       rs765536182       rs765547217       rs765600357       rs765769104       rs766478868       rs766622993       rs766714820       rs766886680       rs766971538       rs767257528       rs767312538       rs767482697       rs767576510       rs767662786       rs767876570       rs767982621       rs768035787       rs768108279       rs768110234       rs768161126       rs768283609       rs768477728       rs768511895       rs768526797       rs768635114       rs769050470       rs769194619       rs769199716       rs769606335       rs769664148       rs769768348       rs769814124       rs769865986       rs770156338       rs770161051       rs770381115       rs770484806       rs770753790       rs771202471       rs771246264       rs771373014       rs771484457       rs771607029       rs771613518       rs771988899       rs772043963       rs772043973       rs772288724       rs772414607       rs772519994       rs772696074       rs772898235       rs773031728       rs773031866       rs773218950       rs773312662       rs773615566       rs773664894       rs773719680       rs774043368       rs774168013       rs774181974       rs774302278       rs774343461       rs774466227       rs774622230       rs774717322       rs775109836       rs775184192       rs775339186       rs775424910       rs775749110       rs775888282       rs776064246       rs776280657       rs776333821       rs776476945       rs776616407       rs776624569       rs776741239       rs776760302       rs776978216       rs777370642       rs777651566       rs777776397       rs777829380       rs777891957       rs777945067       rs777957541       rs778032057       rs778037879       rs778164786       rs778424650       rs778448816       rs778499413       rs778700518       rs778804298       rs779036691       rs779484966       rs779529354       rs779582709       rs779600361       rs779934028       rs780512248       rs780615574       rs780632914       rs780686062       rs780697028       rs780748520       rs781212989       rs781343431       rs781466345       rs781500095       rs781580850       rs796241711      

RRM2基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CATTGAAACGATGCCTTGTG
58
CACGTTCACCATAGGTAGC
58
GCTTCCAAATTGCCATGGA
59
AGAGAAATTCCCTTTCTTTGGG
59
CTTGGTGGAGCGATTTAGC
59
TGGAAGCCATAGAAACAGC
58
TAAGAAGGCAGAGGCTTCC
59
CTGAATGTCCTTGGAGAGGT
59
ATAAGAAGGCAGAGGCTTCC
60
TGAATGTCCTTGGAGAGGT
58
TGAAACGATGCCTTGTGTC
59
CACGTTCACCATAGGTAGC
58
GCTTCCAAATTGCCATGGA
59
GAGAAATTCCCTTTCTTTGGGA
59
GCTTCCAAATTGCCATGGA
59
GAGAAATTCCCTTTCTTTGGGA
59
CTTGGTGGAGCGATTTAGC
59
GAAGCCATAGAAACAGCGG
59
ATAAGAAGGCAGAGGCTTCC
60
TGAATGTCCTTGGAGAGGT
58
      尚未收录相关数据

RRM2基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RRM2基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0009186
C9JXC1(UniProtKB)
IEA
GO:0016491
C9JXC1(UniProtKB)
IEA
GO:0055114
C9JXC1(UniProtKB)
IEA
GO:0000082
P31350(UniProtKB)
TAS
GO:0000083
P31350(UniProtKB)
TAS
GO:0004748
P31350(UniProtKB)
ISS
GO:0004748
P31350(UniProtKB)
IBA
GO:0004748
P31350(UniProtKB)
NAS
GO:0005515
P31350(UniProtKB)
IPI
GO:0005515
P31350(UniProtKB)
IPI
GO:0005515
P31350(UniProtKB)
IPI
GO:0005634
P31350(UniProtKB)
IDA
GO:0005654
P31350(UniProtKB)
TAS
GO:0005737
P31350(UniProtKB)
IDA
GO:0005829
P31350(UniProtKB)
TAS
GO:0005829
P31350(UniProtKB)
TAS
GO:0005971
P31350(UniProtKB)
IBA
GO:0006260
P31350(UniProtKB)
IEA
GO:0009186
P31350(UniProtKB)
IEA
GO:0009263
P31350(UniProtKB)
ISS
GO:0009263
P31350(UniProtKB)
IBA
GO:0015949
P31350(UniProtKB)
TAS
GO:0046872
P31350(UniProtKB)
IEA
GO:0051290
P31350(UniProtKB)
IEA
GO:0055114
P31350(UniProtKB)
IEA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RRM2基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Liver carcinoma 0.120814326 4 0 BeFree_CTD_human
Colorectal Neoplasms 0.12 1 0 CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Polycystic Ovary Syndrome 0.12 1 0 CTD_human
Bladder Neoplasm 0.08 1 0 RGD
Endometrial Neoplasms 0.08 1 0 RGD
Adenocarcinoma 0.0054487 2 0 LHGDN
Spontaneous abortion 0.002367032 1 0 GAD
Malignant neoplasm of breast 0.001628651 6 6 BeFree
Breast Carcinoma 0.001628651 6 6 BeFree
Non-Small Cell Lung Carcinoma 0.001357209 5 0 BeFree
Tumor Progression 0.001085767 4 0 BeFree
Colorectal Cancer 0.001085767 4 0 BeFree
Colorectal Carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of stomach 0.000814326 3 0 BeFree
Malignant neoplasm of urinary bladder 0.000542884 2 0 BeFree
Malignant tumor of cervix 0.000542884 2 0 BeFree
Head and Neck Neoplasms 0.000542884 2 0 BeFree
Neoplasm Metastasis 0.000542884 2 0 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Pancreatic carcinoma 0.000542884 2 0 BeFree
Adenocarcinoma of pancreas 0.000542884 2 0 BeFree
Cervix carcinoma 0.000542884 2 0 BeFree
Malignant neoplasm of pancreas 0.000542884 2 0 BeFree
Malignant neoplasm of prostate 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Prostate carcinoma 0.000542884 2 0 BeFree
Epithelial ovarian cancer 0.000542884 2 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Carcinoma of bladder 0.000542884 2 0 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Squamous cell carcinoma of the head and neck 0.000542884 2 0 BeFree
Pancreatic Ductal Adenocarcinoma 0.000542884 2 0 BeFree
Amyotrophic Lateral Sclerosis 0.000271442 1 0 BeFree
Squamous cell carcinoma 0.000271442 1 0 BeFree
Carcinoma, Transitional Cell 0.000271442 1 0 BeFree
Cystitis 0.000271442 1 0 BeFree
Hepatitis 0.000271442 1 0 BeFree
Hepatitis A 0.000271442 1 0 BeFree
Leukemia, Myelocytic, Acute 0.000271442 1 0 BeFree
melanoma 0.000271442 1 0 BeFree
Adenocarcinoma of lung (disorder) 0.000271442 1 0 BeFree
Adenocarcinoma, Clear Cell 0.000271442 1 0 BeFree
Malignant neoplasm of lung 0.000271442 1 0 BeFree
Transitional cell carcinoma in situ 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Malignant neoplasm of gastrointestinal tract 0.000271442 1 0 BeFree
Frontotemporal Lobar Degeneration 0.000271442 1 0 BeFree
Pancreatic carcinoma non-resectable 0.000271442 1 0 BeFree
Invasive Ductal Breast Carcinoma 0.000271442 1 0 BeFree
Cardiomyopathy, Familial Idiopathic 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree
Amyotrophic Lateral Sclerosis, Sporadic 0.000271442 1 0 BeFree
Urothelial Carcinoma 0.000271442 1 0 BeFree
Nasopharyngeal carcinoma 0.000271442 1 0 BeFree
GRN-related frontotemporal dementia 0.000271442 1 0 BeFree
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