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This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  这个基因编码两块构成核糖核苷二磷酸还原酶,为生产中的分裂细胞的S期的DNA合成之前脱氧核糖核苷酸的必需的酶的非相同亚基之一。这是位于11p15.5的印记基因领域,一个重要的肿瘤抑制基因区域几个基因中的一个。在这一区域的改变已与贝克威思-威德曼综合征,肾母细胞瘤,横纹肌肉瘤,adrenocrotical癌和肺癌,卵巢癌和乳腺癌有关。该基因可能参与涉及该区域恶性肿瘤和疾病的作用。 [由RefSeq的,2008年7月提供]
RRM1基因(以及对应的蛋白质)的细胞分布位置:
RRM1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Non-Small Cell Lung Carcinoma | 0.134310474 | 45 | 6 | BeFree_CTD_human_GAD |
| Adrenocortical carcinoma | 0.120542884 | 2 | 0 | BeFree_CTD_human |
| Neural Tube Defects | 0.12 | 1 | 0 | CTD_human |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Disease Progression | 0.12 | 1 | 0 | CTD_human |
| Liver carcinoma | 0.12 | 1 | 0 | CTD_human |
| Liver Neoplasms, Experimental | 0.08 | 1 | 0 | RGD |
| Seizures | 0.08 | 1 | 0 | RGD |
| Malignant neoplasm of lung | 0.009272631 | 9 | 0 | BeFree_GAD |
| Lung Neoplasms | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
| Adenocarcinoma | 0.005362824 | 3 | 0 | BeFree_GAD_LHGDN |
| Pancreatic Neoplasm | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Malignant neoplasm of pancreas | 0.003452799 | 5 | 0 | BeFree_GAD |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Spontaneous abortion | 0.002367032 | 1 | 0 | GAD |
| Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Kidney Failure, Chronic | 0.002367032 | 1 | 0 | GAD |
| Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
| Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
| Carcinoma, Large Cell | 0.002367032 | 1 | 0 | GAD |
| Carcinoma of lung | 0.001628651 | 6 | 0 | BeFree |
| Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
| Pancreatic carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Leukopenia | 0.000542884 | 2 | 0 | BeFree |
| Nephroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Neutropenia | 0.000542884 | 2 | 0 | BeFree |
| stage, non-small cell lung cancer | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of adrenal cortex | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Nausea and vomiting | 0.000271442 | 1 | 0 | BeFree |
| Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
| Vomiting | 0.000271442 | 1 | 0 | BeFree |
| Agenesis of corpus callosum | 0.000271442 | 1 | 0 | BeFree |
| Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma, Clear Cell | 0.000271442 | 1 | 0 | BeFree |
| Xeroderma Pigmentosum, Complementation Group D | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| myeloblastosis | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adrenal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
| ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
| TDP-43 Proteinopathies | 0.000271442 | 1 | 0 | BeFree |
| Thymus Neoplasms | 0.000271442 | 1 | 0 | BeFree |
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