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Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  层粘连蛋白,一个家庭的细胞外基质糖蛋白,是基底膜的主要非胶原成分。他们已牵涉在多种生物学过程,包括细胞粘着,分化,迁移,信令,神经突向外生长和转移。许多的层粘连蛋白的作用是通过与细胞表面受体的相互作用介导的。这些受体包括整联蛋白家族的成员,以及非整层粘连蛋白结合蛋白。这个基因编码的高亲和力,非整联蛋白家族,层粘连蛋白受体1该受体被不同地称为67 kD的层粘连蛋白受体,37 kD的层粘连蛋白受体的前体(37LRP)和p40核糖体相关蛋白。层粘连蛋白受体1的氨基酸序列在进化过程中高度保守,提示键生物学功能。已经观察到层粘连蛋白受体转录物的水平是在结肠癌组织和肺癌细胞系比它们的正常对应更高。此外,还有在癌细胞这种多肽的上调和它们的侵袭和转移表型之间的相关性。该基因的多个副本存在,但是,他们大多是认为从retropositional事件出现假。已发现此基因的两个编码相同蛋白质可变剪接转录物变体。 [由RefSeq的,2008年7月提供]
RPSA基因(以及对应的蛋白质)的细胞分布位置:
RPSA基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Splenic Hypoplasia | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
| Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
| ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 5 (disorder) | 0.08 | 0 | 0 | MGD |
| Neoplasm Metastasis | 0.004885954 | 18 | 0 | BeFree |
| Lung Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Leukemia, Myelocytic, Acute | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.002171535 | 8 | 0 | BeFree |
| Stomach Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001628651 | 6 | 0 | BeFree |
| Carcinoma of lung | 0.001628651 | 6 | 0 | BeFree |
| Alzheimer's Disease | 0.001357209 | 5 | 0 | BeFree |
| melanoma | 0.001357209 | 5 | 0 | BeFree |
| Colon Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| HIV Infections | 0.001085767 | 4 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001085767 | 4 | 0 | BeFree |
| Tuberculosis | 0.001085767 | 4 | 0 | BeFree |
| Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Crohn Disease | 0.000814326 | 3 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
| Multiple Myeloma | 0.000814326 | 3 | 0 | BeFree |
| Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Acute leukemia | 0.000814326 | 3 | 0 | BeFree |
| Liposarcoma, Myxoid | 0.000814326 | 3 | 0 | BeFree |
| Cholangiocarcinoma | 0.000814326 | 3 | 0 | BeFree |
| Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
| Coronary Artery Disease | 0.000814326 | 3 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Experimental Autoimmune Encephalomyelitis | 0.000542884 | 2 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.000542884 | 2 | 0 | BeFree |
| Ischemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Malaria | 0.000542884 | 2 | 0 | BeFree |
| Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
| Teratocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000542884 | 2 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000542884 | 2 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Ataxia | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
| Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
| Echinococcosis | 0.000271442 | 1 | 0 | BeFree |
| Eczema | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| HTLV-I Infections | 0.000271442 | 1 | 0 | BeFree |
| Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Meningitis | 0.000271442 | 1 | 0 | BeFree |
| Mitral Valve Stenosis | 0.000271442 | 1 | 0 | BeFree |
| Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
| Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
| Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Septicemia | 0.000271442 | 1 | 0 | BeFree |
| T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Pleural Effusion, Malignant | 0.000271442 | 1 | 0 | BeFree |
| Synovial Cyst | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
| Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Sepsis | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Cardiac sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
| Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Dementia | 0.000271442 | 1 | 0 | BeFree |
| Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Myxoid cyst | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Sclerosing Hemangioma | 0.000271442 | 1 | 0 | BeFree |
| Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Severe Sepsis | 0.000271442 | 1 | 0 | BeFree |
| ALZHEIMER DISEASE 2 | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic pulmonary arterial hypertension | 0.000271442 | 1 | 0 | BeFree |
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