更多...
收起
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  核糖体,催化蛋白质合成的细胞器,由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体蛋白,它是40S亚基的一个组成部分。该蛋白属于S27E家族核糖体的蛋白质。它包含可结合锌的C4型锌指结构域。所编码的蛋白质已被证明能够结合核酸。它位于细胞质核糖体组成部分,但它也被在细胞核中检测到。在鼠的研究表明,核糖体蛋白S27中在40S亚基临近核糖体蛋白S18和共价连接到翻译起始因子eIF3。作为典型编码核糖体蛋白的基因,有该基因通过基因组分散的多个经处理的假基因。 [由RefSeq的,2008年7月提供]
RPS27基因(以及对应的蛋白质)的细胞分布位置:
RPS27基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Pfaundler-Hurler Syndrome | 0.001628651 | 6 | 0 | BeFree |
Mucopolysaccharidosis I | 0.001357209 | 5 | 0 | BeFree |
melanoma | 0.001085767 | 4 | 0 | BeFree |
Mucopolysaccharidoses | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 1 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Hartnup Disease | 0.000542884 | 2 | 0 | BeFree |
Mucopolysaccharidosis V | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Lysosomal Storage Diseases | 0.000542884 | 2 | 0 | BeFree |
Hurler-Scheie Syndrome | 0.000542884 | 2 | 0 | BeFree |
Mucopolysaccharidosis Type IIIA | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
alpha-L-Iduronidase Deficiency | 0.000542884 | 2 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Brain Diseases | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
Nodule | 0.000271442 | 1 | 0 | BeFree |
Precursor cell lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
Skeletal dysplasia | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Anemia, Diamond-Blackfan | 0.000271442 | 1 | 0 | BeFree |
Aggressive Non-Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。