RPLP1(ribosomal protein, large, P1)
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 核糖体，催化蛋白质合成的细胞器，由一个小40S亚基和60S大亚基。一起这些亚基组成的4 RNA种类和大约80结构不同的蛋白质。该基因编码一种核糖体磷蛋白，它是60S亚基的一个组成部分。的蛋白，其是大肠杆菌L7 / L12核糖体蛋白的功能等同物，属于L12P家族核糖体的蛋白质。它在蛋白质合成的延伸步骤中起重要作用。不像大多数核糖体蛋白，它是基本的，所编码的蛋白质是酸性的。其C-末端是几乎相同的核糖体磷蛋白P0和P2的C-末端。的P1蛋白可以与P0和P2相互作用以形成一个五聚体复合物组成的P1和P2二聚体和P0单体。该蛋白质位于细胞质中。两个编码不同蛋白质可变剪接转录物变体已观察到。作为典型编码核糖体蛋白的基因，有该基因通过基因组分散的多个经处理的假基因。 [由RefSeq的，2008年7月提供]
基因本体信息
RPLP1基因（以及对应的蛋白质）的细胞分布位置：
- 溶酶体
- 内涵体
- 细胞核
- 细胞质
- 液泡
- 细胞膜
- 细胞外基质
- 内质网
- 线粒体
- 高尔基体
- 细胞骨架
RPLP1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Rheumatoid Arthritis | 0.002367032 | 1 | 1 | GAD |
| Atrial Fibrillation | 0.002367032 | 1 | 1 | GAD |
| Brain Diseases | 0.002367032 | 1 | 1 | GAD |
| Chronic Lymphocytic Leukemia | 0.002367032 | 1 | 1 | GAD |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Lyme Disease | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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