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The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是核激素受体的NR1亚科的成员。它可以结合作为单体或作为同二聚体激素上游的几个基因的应答元件以增强这些基因的表达。所编码的蛋白质已被证明与NM23-2,参与器官发生和分化,以及与NM23-1,肿瘤转移抑制候选基因的产物的核苷二磷酸激酶相互作用。另外,已经表明在参与昼夜节律某些基因的转录调节来帮助。编码不同亚型四个抄本变形已经为这个基因描述。 [由RefSeq的,2014年2月提供]
RORA基因(以及对应的蛋白质)的细胞分布位置:
RORA基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mental Depression | 0.125276948 | 2 | 1 | BeFree_GAD_GWASCAT |
| Asthma | 0.120271442 | 2 | 1 | BeFree_GWASCAT |
| Autistic Disorder | 0.12 | 2 | 0 | CTD_human |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Bipolar Disorder | 0.005819831 | 6 | 9 | BeFree_GAD |
| Anoxia | 0.0054487 | 2 | 0 | LHGDN |
| Robinow Syndrome | 0.004071628 | 15 | 0 | BeFree |
| BRACHYDACTYLY, TYPE B1 | 0.003800186 | 14 | 0 | BeFree |
| Chronic Lymphocytic Leukemia | 0.003528744 | 13 | 0 | BeFree |
| Atherosclerosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Age related macular degeneration | 0.002909916 | 2 | 1 | BeFree_GAD |
| Choriocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Dyslipidemias | 0.00272435 | 1 | 0 | LHGDN |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Choroidal Neovascularization | 0.002367032 | 1 | 0 | GAD |
| Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
| Major Depressive Disorder | 0.002367032 | 1 | 0 | GAD |
| Robinow syndrome, autosomal recessive | 0.001628651 | 6 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
| Brachydactyly | 0.001357209 | 5 | 0 | BeFree |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001357209 | 5 | 0 | BeFree |
| melanoma | 0.001085767 | 4 | 0 | BeFree |
| Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
| Stomach Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000814326 | 3 | 2 | BeFree |
| Renal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Depressive disorder | 0.000814326 | 3 | 10 | BeFree |
| Dwarfism | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Post-Traumatic Stress Disorder | 0.000814326 | 3 | 0 | BeFree |
| Rhabdoid Tumor of the Kidney | 0.000814326 | 3 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.000814326 | 3 | 0 | BeFree |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Basal Cell Nevus Syndrome | 0.000542884 | 2 | 0 | BeFree |
| Bone Diseases | 0.000542884 | 2 | 0 | BeFree |
| Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000542884 | 2 | 0 | BeFree |
| Skeletal dysplasia | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 2 | BeFree |
| Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Renal carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Drug abuse | 0.000271442 | 1 | 0 | BeFree |
| Epithelial cyst | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy | 0.000271442 | 1 | 3 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Hamartoma Syndrome, Multiple | 0.000271442 | 1 | 0 | BeFree |
| Ventricular Septal Defects | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
| Ischemia | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Liver diseases | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 0 | BeFree |
| Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
| Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Osteoporosis | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
| Dermatologic disorders | 0.000271442 | 1 | 0 | BeFree |
| Syndactyly | 0.000271442 | 1 | 0 | BeFree |
| Fibromatosis, Aggressive | 0.000271442 | 1 | 0 | BeFree |
| Seasonal Affective Disorder | 0.000271442 | 1 | 9 | BeFree |
| Liver Failure | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
| Teratocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm, Residual | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis of the hand | 0.000271442 | 1 | 0 | BeFree |
| Exudative age-related macular degeneration | 0.000271442 | 1 | 0 | BeFree |
| Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Osteoarthritis of distal interphalangeal joint | 0.000271442 | 1 | 0 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Hepatitis B, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Cerebellar atrophy | 0.000271442 | 1 | 0 | BeFree |
| End Stage Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Adenoviral infections | 0.000271442 | 1 | 0 | BeFree |
| Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| winter depression | 0.000271442 | 1 | 9 | BeFree |
| Sleeplessness | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| LATERAL MENINGOCELE SYNDROME | 0.000271442 | 1 | 0 | BeFree |
| Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Nonalcoholic Steatohepatitis | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
| Acute-On-Chronic Liver Failure | 0.000271442 | 1 | 0 | BeFree |
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