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The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质中含有RING指基序,并充当转录调节。此蛋白已被证明与相互作用,并抑制,TRPS1,GATA-介导的转录的转录抑制活性。转录阻抑ZNF278 / PATZ被发现与该蛋白相互作用,并因此减少通过该蛋白介导的雄激素受体依赖性转录的增强。在小鼠和大鼠的对应的研究表明在精子发生这种蛋白的作用。这种基因的一个假的1号染色体上[由RefSeq的,2010年7月提供]研究发现
RNF4基因(以及对应的蛋白质)的细胞分布位置:
RNF4基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
Prader-Willi Syndrome | 0.000542884 | 2 | 0 | BeFree |
Promyelocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Fanconi Anemia | 0.000271442 | 1 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukoencephalopathy, Progressive Multifocal | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of Male Breast | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of male breast | 0.000271442 | 1 | 0 | BeFree |
Reifenstein Syndrome | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000271442 | 1 | 0 | BeFree |
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