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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
[中文简述(自动翻译):]  该基因编码Rho家族小GTP酶的的成员,其中非活性GDP结合和积极的GTP结合状态和功能在信号转导分子级联交换机之间循环。 RHO蛋白质促进细胞骨架的重组和调节细胞形状,附件和运动。所编码的蛋白质有利于官能鸟嘌呤核苷酸交换因子的易位从细胞质到质膜,其中Ras相关C3肉毒杆菌毒素底物1被激活,以促进板状伪足形成和细胞迁移(GEF)络合物。两个相关的假已经确定染色体上20和X [由RefSeq的,2011年8月提供]
RHOG基因(以及对应的蛋白质)的细胞分布位置:
RHOG基因的本体(GO)信息:
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