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The protein encoded by this gene is a small Rho GTPase and a candidate tumor suppressor. The encoded protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个小的Rho GTP酶和候选肿瘤抑制基因。所编码的蛋白质与滞-3蛋白,必需的有丝分裂细胞分裂泛素E3连接相互作用。这种蛋白抑制某些类型的乳腺癌的生长和扩散。已发现该基因编码不同亚型三个抄本变形。 [由RefSeq的,2011年11月提供]
RHOBTB2基因(以及对应的蛋白质)的细胞分布位置:
RHOBTB2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Peripheral Neuropathy | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Mammary Neoplasms | 0.006263026 | 4 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.005081451 | 11 | 0 | BeFree_GAD |
| Bladder Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Stomach Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Breast Carcinoma | 0.002714419 | 10 | 0 | BeFree |
| Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
| Lyme Disease | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Carcinoma of bladder | 0.000542884 | 2 | 0 | BeFree |
| Sporadic Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Acrodermatitis atrophicans chronica | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
| Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
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