RGS1(regulator of G-protein signaling 1) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库
1q31

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  这个基因编码G蛋白信号传导家族的调节器的一个成员。该蛋白质位于质膜的胞质侧,并包含所谓的RGS域的保守的,120个氨基酸基序。该蛋白质通过结合到活化的GTP结合?阿尔法亚基和充当GTP酶激活蛋白(GAP),增加对GTP GDP的转化率衰减G蛋白的信号传导活性。此水解允许对G的α亚基结合?β/γ亚基的异二聚体,形成无活性的G蛋白异源,从而结束信号。 [由RefSeq的,2008年7月提供]

RGS1基因的碱基序列:[NCBI]
RGS1基因的碱基突变:           显示全部snp
rs1323291       rs1547624       rs1923948       rs1923949       rs2246829       rs2760531       rs2760532       rs2760533       rs2760534       rs2816306       rs2816307       rs2816308       rs2816309       rs2816310       rs2816311       rs2984920       rs3011684       rs3189653       rs3790365       rs3806353       rs3806354       rs4658058       rs6701795       rs6702128       rs7535818       rs10921199       rs10921200       rs10921201       rs10921202       rs11420006       rs12059774       rs12086898       rs12136860       rs16834436       rs16834437       rs41265197       rs41265199      
rs60719978       rs74130688       rs74130689       rs76219467       rs76289714       rs77097241       rs77617886       rs79454488       rs79580559       rs80047655       rs80168372       rs80272816       rs113090598       rs113235326       rs113660313       rs113718474       rs114098153       rs114782429       rs115518462       rs116702915       rs118054210       rs118185025       rs138179272       rs138490876       rs139633310       rs139775411       rs139987236       rs140600315       rs140708687       rs140779829       rs141227492       rs141489593       rs142034366       rs143342641       rs144550089       rs144803737       rs145482899       rs146022693       rs146894683       rs147398435       rs147421566       rs148323942       rs149666517       rs149919199       rs150745219       rs150820500       rs181973067       rs183294128       rs185238451       rs186196699       rs186914437       rs188336399       rs188517867       rs189594272       rs190135955       rs191402596       rs192580102       rs192836990       rs199651205       rs199992748       rs200680781       rs201470045       rs201993663       rs367632361       rs369963644       rs370009315       rs371061702       rs371471835       rs371716956       rs371838216       rs372080177       rs372322581       rs372740862       rs372953728       rs373596324       rs373627768       rs373786419       rs374040122       rs374108570       rs374150663       rs374699043       rs375194538       rs375687227       rs375853268       rs376360212       rs376943618       rs377284124       rs377512997       rs377649065       rs397696811       rs527357234       rs527422109       rs527632667       rs527853574       rs527973481       rs528377606       rs528580052       rs528642345       rs530912821       rs531897350       rs533439104       rs533451340       rs533948018       rs534056825       rs535873438       rs536925055       rs537603910       rs537812331       rs538204163       rs538578556       rs539218157       rs539321072       rs539968592       rs540043264       rs541047121       rs542280535       rs542985822       rs543003897       rs543539061       rs543667784       rs544120416       rs544619550       rs545380345       rs545727464       rs546457925       rs547211722       rs548171485       rs548491400       rs548830291       rs549116435       rs549427554       rs549907455       rs550575248       rs550749814       rs551753808       rs551933514       rs552494830       rs552698796       rs553612348       rs555669655       rs556061986       rs557317509       rs557836431       rs558888095       rs559762390       rs559825473       rs559978048       rs560968517       rs561650615       rs561769177       rs563126750       rs563255837       rs563846514       rs563977117       rs564183321       rs566130339       rs566167710       rs567096823       rs568140380       rs568169550       rs568436550       rs568789737       rs569865545       rs570064334       rs570602811       rs571502168       rs571563016       rs572034569       rs572603580       rs573050126       rs573246885       rs573610662       rs574252259       rs574265710       rs575580371       rs576294177       rs577644549       rs745456551       rs745712891       rs745812628       rs746017875       rs746297297       rs746537975       rs746696088       rs748019441       rs748030016       rs748410689       rs748501879       rs748621906       rs748980909       rs749274050       rs749426395       rs749496425       rs749651216       rs749682768       rs750850227       rs750962139       rs751496702       rs751842638       rs752379646       rs752662240       rs752871129       rs753247315       rs753674143       rs753822477       rs754287081       rs754506423       rs754783085       rs755098545       rs755701133       rs755945894       rs755972758       rs756404578       rs756727811       rs757066163       rs757276012       rs757374288       rs757618719       rs757635390       rs758026916       rs758517280       rs758642800       rs759173439       rs759450588       rs759652326       rs759953772       rs760078546       rs760178837       rs760524065       rs760613828       rs761159017       rs761417613       rs761858661       rs762712433       rs762771278       rs763170108       rs763179216       rs763518306       rs764017544       rs764258837       rs764597990       rs764682079       rs764736667       rs764744379       rs764944580       rs765037381       rs765426961       rs765487757       rs766426857       rs766595403       rs767577034       rs767584356       rs767700460       rs767806942       rs767893411       rs768187942       rs768631741       rs768973607       rs769053580       rs769086763       rs769468717       rs769687107       rs769794511       rs769815126       rs769907096       rs770266951       rs770318014       rs770535912       rs770835460       rs770851828       rs770999624       rs771181351       rs771355998       rs771375397       rs771557568       rs771575568       rs771753443       rs772170382       rs772479640       rs772513476       rs772736379       rs772893793       rs772930426       rs773093196       rs773227371       rs773426255       rs773804420       rs773999939       rs774346849       rs774535088       rs774683897       rs774919642       rs775591372       rs775780695       rs776149646       rs776810464       rs776826374       rs777814744       rs778017564       rs778116545       rs778120235       rs778130407       rs778495843       rs778516750       rs778793586       rs779067295       rs779334874       rs779640636       rs779824898       rs780143481       rs780404249       rs780812724       rs780939760       rs781045595       rs781457000       rs781645187       rs147398435      

RGS1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TGGATATGAAAGCATACCTGAG
58
AGCAGAAAGTACATCCTTGG
58
TGGATATGAAAGCATACCTGAG
58
AGCAGAAAGTACATCCTTGG
58
CTTGCCAACCAAACTGGTC
60
CAGCCAGAACTCAATATTCTCC
59
ACTCATTCACTTCTAGACGAC
57
GGTATGCTTTCATATCCATTCC
57
CACTCATTCACTTCTAGACGA
57
GGTATGCTTTCATATCCATTCC
57
TGGATATGAAAGCATACCTGAG
58
GCAGCAGAAAGTACATCCT
58
CCAAAGGAATTGAAAGGAACCA
60
AGCAGAAAGTAAAGTCTTTGGC
60
TGGATATGAAAGCATACCTGAG
58
GCAGAAAGTACATCCTTGGA
58
TGGATATGAAAGCATACCTGAG
58
GCAGCAGAAAGTACATCCT
58
TGGATATGAAAGCATACCTGAG
58
GCAGAAAGTACATCCTTGGA
58
      尚未收录相关数据

RGS1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RGS1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001965
Q08116(UniProtKB)
IPI
GO:0005096
Q08116(UniProtKB)
IDA
GO:0005096
Q08116(UniProtKB)
IDA
GO:0005516
Q08116(UniProtKB)
TAS
GO:0005829
Q08116(UniProtKB)
IDA
GO:0005886
Q08116(UniProtKB)
TAS
GO:0006955
Q08116(UniProtKB)
TAS
GO:0007165
Q08116(UniProtKB)
IDA
GO:0007186
Q08116(UniProtKB)
IDA
GO:0007193
Q08116(UniProtKB)
TAS
GO:0008277
Q08116(UniProtKB)
IEA
GO:0009968
Q08116(UniProtKB)
IEA
GO:0031234
Q08116(UniProtKB)
IDA
GO:0043547
Q08116(UniProtKB)
IDA
GO:0043547
Q08116(UniProtKB)
IDA
GO:0061737
Q08116(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RGS1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Osteosarcoma 0.12 1 0 CTD_human
Dermatologic disorders 0.12 1 0 CTD_human
Dermatitis, Allergic Contact 0.12 1 0 CTD_human
Arsenic Poisoning 0.12 1 0 CTD_human
Celiac Disease 0.012649486 6 1 BeFree_GAD
Multiple Sclerosis 0.007372538 4 0 BeFree_GAD
Diabetes Mellitus, Insulin-Dependent 0.004734064 2 0 GAD
melanoma 0.00272435 1 0 LHGDN
Autoimmune Diseases 0.002367032 1 0 GAD
Squamous cell carcinoma 0.002367032 1 0 GAD
Head and Neck Neoplasms 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
Juvenile arthritis 0.002367032 1 0 GAD
Aortic Aneurysm 0.000271442 1 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Atherosclerosis 0.000271442 1 0 BeFree
Leukemia, T-Cell 0.000271442 1 0 BeFree
Adult T-Cell Lymphoma/Leukemia 0.000271442 1 0 BeFree
Lymphoma 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Tumor Progression 0.000271442 1 0 BeFree
Aortic aneurysm without mention of rupture NOS 0.000271442 1 0 BeFree
Aortic Aneurysm, Ruptured 0.000271442 1 0 BeFree
Vascular inflammations 0.000271442 1 0 BeFree
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