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This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):] 这个基因编码G蛋白信号传导家族的调节器的一个成员。该蛋白质位于质膜的胞质侧,并包含所谓的RGS域的保守的,120个氨基酸基序。该蛋白质通过结合到活化的GTP结合?阿尔法亚基和充当GTP酶激活蛋白(GAP),增加对GTP GDP的转化率衰减G蛋白的信号传导活性。此水解允许对G的α亚基结合?β/γ亚基的异二聚体,形成无活性的G蛋白异源,从而结束信号。 [由RefSeq的,2008年7月提供]
RGS1基因(以及对应的蛋白质)的细胞分布位置:
RGS1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Osteosarcoma | 0.12 | 1 | 0 | CTD_human |
Dermatologic disorders | 0.12 | 1 | 0 | CTD_human |
Dermatitis, Allergic Contact | 0.12 | 1 | 0 | CTD_human |
Arsenic Poisoning | 0.12 | 1 | 0 | CTD_human |
Celiac Disease | 0.012649486 | 6 | 1 | BeFree_GAD |
Multiple Sclerosis | 0.007372538 | 4 | 0 | BeFree_GAD |
Diabetes Mellitus, Insulin-Dependent | 0.004734064 | 2 | 0 | GAD |
melanoma | 0.00272435 | 1 | 0 | LHGDN |
Autoimmune Diseases | 0.002367032 | 1 | 0 | GAD |
Squamous cell carcinoma | 0.002367032 | 1 | 0 | GAD |
Head and Neck Neoplasms | 0.002367032 | 1 | 0 | GAD |
Neoplasm Recurrence, Local | 0.002367032 | 1 | 0 | GAD |
Neoplasms, Second Primary | 0.002367032 | 1 | 0 | GAD |
Juvenile arthritis | 0.002367032 | 1 | 0 | GAD |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Aortic aneurysm without mention of rupture NOS | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Ruptured | 0.000271442 | 1 | 0 | BeFree |
Vascular inflammations | 0.000271442 | 1 | 0 | BeFree |
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