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Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
[中文简述(自动翻译):] 根蛋白是细胞骨架蛋白,可能是在连接的肌动蛋白的质膜重要。它是在序列上都埃兹和膜突蛋白高度相似。该根蛋白基因原位杂交被定位由荧光11q23的。代表一个假(RDXP2)截断版本被分配到Xp21.3。这似乎缺乏内含子的另一个假(RDXP1)由南部和PCR分析映射到11P。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的,2012年5月提供]
RDX基因(以及对应的蛋白质)的细胞分布位置:
RDX基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
DEAFNESS, AUTOSOMAL RECESSIVE, 24 | 0.36 | 1 | 3 | CLINVAR_CTD_human_UNIPROT |
Cholestasis | 0.12 | 1 | 0 | CTD_human |
Jaundice, Chronic Idiopathic | 0.08 | 0 | 0 | MGD |
Neoplasm Metastasis | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Liver diseases | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
hearing impairment | 0.00272435 | 1 | 0 | LHGDN |
Glaucoma, Open-Angle | 0.002367032 | 1 | 0 | GAD |
Tumor Progression | 0.001628651 | 6 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000814326 | 3 | 0 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Female Pseudohermaphroditism | 0.000542884 | 2 | 1 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Bronchioloalveolar Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Chordoma | 0.000271442 | 1 | 0 | BeFree |
Shigella Infections | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Guillain-Barre Syndrome | 0.000271442 | 1 | 0 | BeFree |
Hyperbilirubinemia | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Meningioma | 0.000271442 | 1 | 0 | BeFree |
Neurofibromatosis 2 | 0.000271442 | 1 | 0 | BeFree |
Retroviridae Infections | 0.000271442 | 1 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Hearing Loss, Mixed Conductive-Sensorineural | 0.000271442 | 1 | 1 | BeFree |
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonsyndromic Deafness | 0.000271442 | 1 | 0 | BeFree |
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