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This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因是RAS相关区域家族中的一员。它用作一种肿瘤抑制,并在各种癌症中被灭活。该编码的蛋白定位于中心体和微管,并与RAS,RAP1等几个拉斯般的小GTP酶的GTP活化形式的联营公司。该蛋白质调节淋巴细胞粘附和响应于激活RAP1或的Ras抑制细胞生长。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的,2008年7月提供]
RASSF5基因(以及对应的蛋白质)的细胞分布位置:
RASSF5基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neuroblastoma | 0.123267234 | 2 | 0 | BeFree_CTD_human_LHGDN |
| Kidney Neoplasm | 0.12 | 1 | 0 | CTD_human |
| Lupus Erythematosus, Systemic | 0.08 | 0 | 0 | MGD |
| Liver carcinoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
| Thyroid Neoplasm | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of breast | 0.002638474 | 2 | 0 | BeFree_GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
| Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Ganglioneuroma | 0.000271442 | 1 | 0 | BeFree |
| Glioma | 0.000271442 | 1 | 0 | BeFree |
| Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
| Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
| Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
| Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
| Conventional (Clear Cell) Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Growth Hormone-Secreting Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
| Gastric Cardia Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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