RASAL1(RAS protein activator like 1 (GAP1 like)) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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12q23-q24
基因染色体位置图

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

[中文简述(自动翻译):]  由该基因编码的蛋白质是GAP1家族GTP酶激活蛋白质的成员。这些蛋白质会刺激正常RAS p21蛋白的GTP酶活性而不是它的致癌对应。作为RAS功能的抑制剂,蛋白质增强导致的RAS的非活性的GDP结合形式,从而允许细胞增殖和分化的控制RAS蛋白的弱内在GTP酶活性。这个特定的家庭成员包含它们RasGAP蛋白质GAP1亚科的特性,但是,与此相反的其他GAP1家族成员结构域,此蛋白质的强烈和选择性在内分泌组织中表达。编码不同亚型选择性剪接转录变异体已被描述[按RefSeq的,2010年7月提供]

RASAL1基因的碱基序列:[NCBI]
RASAL1基因的碱基突变:           显示全部snp
rs1674096       rs116763556       rs143284394       rs376513538       rs545000066       rs558222065       rs562492844       rs3759378       rs7975596       rs34170110       rs36081841       rs73208704       rs78847209       rs111508146       rs112300082       rs115466121       rs117089794       rs117864705       rs138743238       rs140407240       rs141607050       rs141928754       rs143704733       rs143941696       rs145197034       rs148229864       rs149469661       rs150144380       rs150673548       rs151076001       rs182599930       rs183470992       rs183841308       rs185600546       rs186661244       rs187151688       rs188457184      
rs191565344       rs192121577       rs192888904       rs369681327       rs397706509       rs528594253       rs531473692       rs533299669       rs533406577       rs533915753       rs534124931       rs535209074       rs535648282       rs536107420       rs539430108       rs540027180       rs542208750       rs542681077       rs544063046       rs544468399       rs545291937       rs545862889       rs548121331       rs550608714       rs550889408       rs551671490       rs553637895       rs555601067       rs555767556       rs557278462       rs557683730       rs560151760       rs562619820       rs566557068       rs568049909       rs568607243       rs572336872       rs573768710       rs575558274       rs575709568       rs577996801       rs736284       rs736285       rs751280       rs751281       rs936387       rs936388       rs1284865       rs1284871       rs1284872       rs1284873       rs1284874       rs1284875       rs1284876       rs1284877       rs1284878       rs1284879       rs1284880       rs1284881       rs1284882       rs1293810       rs1293811       rs1379864       rs1613022       rs1613480       rs1613964       rs1613990       rs1674097       rs1674098       rs1674099       rs1674100       rs1674101       rs1674103       rs1674104       rs1674105       rs1674113       rs1732771       rs1732772       rs1732798       rs1807335       rs1824276       rs1824277       rs1902955       rs2061386       rs2256465       rs2305907       rs2305908       rs2305909       rs2305910       rs2305911       rs2468355       rs2701619       rs2701620       rs2701621       rs2701626       rs3759379       rs3782881       rs3888858       rs3888859       rs4505119       rs7314336       rs7953387       rs7960087       rs7962821       rs7963750       rs7964202       rs7971164       rs7976407       rs7978460       rs7978582       rs10161235       rs10507237       rs10603536       rs11066493       rs11066494       rs11066496       rs11610033       rs11612134       rs11613119       rs11830567       rs12229054       rs12300313       rs12422305       rs12422636       rs12422659       rs12423351       rs12423570       rs12423732       rs12423838       rs12423906       rs12425097       rs12425107       rs12426422       rs12427427       rs12819481       rs12826437       rs16934236       rs16934243       rs16942569       rs16942582       rs17643821       rs17700336       rs33962607       rs33988430       rs34456143       rs34598602       rs34945890       rs35026779       rs35122341       rs35235298       rs35259724       rs35293017       rs35505918       rs35612573       rs35786393       rs35910801       rs36067474       rs36093755       rs55857148       rs56174199       rs56340203       rs56395319       rs56901983       rs57245306       rs59511442       rs60757124       rs61740514       rs61741904       rs61759863       rs61759864       rs61941395       rs61941396       rs71086144       rs71086145       rs71445601       rs71455142       rs71465879       rs71465880       rs71465881       rs71465882       rs73207006       rs73207007       rs73207009       rs73207010       rs73207011       rs73207013       rs73207014       rs73207015       rs73207016       rs73207017       rs73207018       rs73207019       rs73207024       rs73207025       rs73207027       rs73207092       rs73207098       rs73207099       rs73207101       rs73208703       rs73439822       rs74477223       rs74505652       rs74582021       rs74783089       rs74836121       rs74937438       rs75185906       rs75426961       rs75703273       rs75998361       rs76484307       rs76511905       rs76557824       rs77160473       rs77196406       rs77857590       rs78352563       rs78358273       rs78591522       rs78729431       rs78869307       rs78877576       rs78888236       rs78931443       rs79042200       rs79148912       rs79363987       rs79612265       rs79696888       rs80307726       rs111404822       rs111690926       rs111849270       rs111853407       rs112031974       rs112175468       rs112371393       rs112381009       rs112419326       rs112444989       rs112459491       rs112623602       rs112818161       rs112836826       rs112930117       rs112977155       rs113002402       rs113003385       rs113040486       rs113087701       rs113099893       rs113234955       rs113425247       rs113627600       rs113658895       rs113870254       rs113962286       rs114046720       rs114061862       rs114069162       rs114082247       rs114098151       rs114208280       rs114340616       rs114358122       rs114454388       rs114458989       rs114466295       rs114554819       rs114567810       rs114597209       rs114679988       rs114722893       rs114752692       rs114755787       rs114757798       rs114767140       rs115117790       rs115198254       rs115315287       rs115436611       rs115470689       rs115486967       rs115506727       rs115509344       rs115519676       rs115549046       rs115599720       rs115760006       rs115978875       rs115989112       rs116124176       rs116279838       rs116311409       rs116485092       rs116547898       rs116592947       rs116782043       rs116782402       rs116905766       rs117091084       rs117312476       rs117340338       rs117363714       rs117480141       rs117600998       rs117716873       rs117814532       rs118061364       rs118062729       rs118121765       rs118133147       rs137930457       rs137949771       rs138040733       rs138125207       rs138152363       rs138237047       rs138458660       rs138469096       rs138494388       rs138807317       rs138820670       rs138927914       rs138940004       rs138940470       rs139030196       rs139146871       rs139171712       rs139178103       rs139215075       rs139219731       rs139282882       rs139292837       rs139329607       rs139356328       rs139458626       rs139573405       rs139689700       rs139807465       rs140062325       rs140071990       rs140096373       rs140140724       rs140221973       rs140271939       rs140447785       rs140560284       rs140563833       rs140623604       rs140740372       rs140785723       rs141188926       rs141248555       rs141266799       rs141337603       rs141386207       rs141435232       rs141439531       rs141467289       rs141493209       rs141545340       rs141550692       rs141559105       rs141788578       rs141892919       rs142148147       rs142253370       rs142331902       rs142414221       rs142463372       rs142478473       rs142515094       rs142526299       rs142556970       rs142687628       rs142748655       rs142798646       rs142936191       rs143036009       rs143084883       rs143194167       rs143280752       rs143431574       rs143527778       rs143662886       rs143684371       rs143768388       rs143783324       rs143821565       rs143871397       rs143883660       rs143974863       rs144041447       rs144083793       rs144170305       rs144308437       rs144377548       rs144525203       rs144567747       rs144593587       rs144631652       rs144658188       rs144694121       rs144731755       rs144974155       rs145139178       rs145160110       rs145166265       rs145345802       rs145374624       rs145400350       rs145488408       rs145610587       rs145669580       rs145751777       rs145770939       rs145802134       rs146065175       rs146085296       rs146208169       rs146436822       rs146488011       rs146551951       rs146589835       rs146594348       rs146608350       rs146632065       rs146662259       rs146708893       rs146865681       rs146988485       rs147181578       rs147185286       rs147235005       rs147426193       rs147442333       rs147515894       rs147692878       rs147755661       rs147771814       rs147788291       rs147894971       rs147983803       rs148179381       rs148186900       rs148239033       rs148281552       rs148285524       rs148353967       rs148402420       rs148436962       rs148454620       rs148498985       rs148534085       rs148574885       rs148805987       rs148907126       rs148924845       rs148977743       rs149148612       rs149283617       rs149378240       rs149732792       rs149779001       rs149869393       rs150016253       rs150032840       rs150043739       rs150321616       rs150474525       rs150499262       rs150546216       rs150572787       rs150670339       rs150792397       rs150829834       rs150844584       rs150845235       rs150954103       rs151114938       rs151129597       rs151201489       rs151285967       rs151288599       rs151317113       rs180945062       rs180953587       rs181066159       rs181083260       rs181085497       rs181183595       rs181316025       rs181553902       rs181561492       rs181681096       rs181685651       rs181859181       rs181904261       rs181970289       rs182170652       rs182272330       rs182407256       rs182541534       rs182616498       rs182758010       rs182925059       rs183008754       rs183022162       rs183028028       rs183036731       rs183263506       rs183272138       rs183360433       rs183373096       rs183639292       rs183802200       rs183916678       rs183929966       rs183938500       rs184005282       rs184078674       rs184089526       rs184131828       rs184236542       rs184254130       rs184287388       rs184357681       rs184630780       rs184764327       rs184905618       rs184939279       rs185010862       rs185436972       rs185443164       rs185550370       rs185596903       rs185774050       rs185843896       rs185893869       rs186420346       rs186427687       rs186538579       rs186539390       rs186551966       rs186552705       rs186672266       rs186820565       rs187118201       rs187146531       rs187237042       rs187261824       rs187269257       rs187272235       rs187338024       rs187398150       rs187416032       rs187479138       rs187617878       rs187745478       rs187904169       rs187936585       rs188088244       rs188230394       rs188851054       rs188858936       rs188898304       rs189020549       rs189159984       rs189190190       rs189457620       rs189511047       rs189743270       rs189758072       rs189802974       rs189929817       rs189948175       rs189958241       rs189992882       rs190101109       rs190255055       rs190489302       rs190496041       rs190550020       rs190701695       rs190716943       rs190807539       rs190860705       rs190969340       rs191196719       rs191255635       rs191483138       rs191617932       rs191658361       rs191683395       rs191761983       rs191931666       rs192121577       rs192159030       rs192243081       rs192299920       rs192388437       rs192461950       rs192469451       rs192539786       rs192780825       rs192828718       rs193003262       rs193144574       rs193184132       rs193208024       rs199511842       rs199548072       rs199562986       rs199699304       rs199748998       rs199799964       rs199908089       rs199970864       rs200091326       rs200100020       rs200175078       rs200175893       rs200200008       rs200267385       rs200350606       rs200507195       rs200565872       rs200610789       rs200723951       rs200729934       rs200888284       rs200909206       rs200935362       rs200952426       rs200968955       rs201028670       rs201065218       rs201072698       rs201119080       rs201231208       rs201266361       rs201278006       rs201347572       rs201379300       rs201380507       rs201384471       rs201422502       rs201452149       rs201457819       rs201490687       rs201565397       rs201571351       rs201674516       rs201691381       rs201754782       rs201775307       rs202023606       rs202032513       rs202127063       rs202143463       rs367591172       rs367641450       rs367924897       rs368169508       rs368185324       rs368316612       rs368437876       rs368503142       rs368533675       rs368561887       rs368672089       rs368725777       rs368835731       rs368956948       rs369224953       rs369328234       rs369348565       rs369370670       rs369697367       rs369964052       rs369971530       rs370006678       rs370026733       rs370035582       rs370191767       rs370406183       rs370426676       rs370483079       rs370491950       rs370529158       rs370733523       rs370790688       rs371137700       rs371368874       rs371474518       rs371501617       rs371581968       rs371604812       rs371716541       rs371725387       rs371819478       rs371917753       rs371960438       rs372102614       rs372288724       rs372426715       rs372608661       rs372736495       rs372767854       rs373333866       rs373363826       rs373371809       rs373447601       rs373600540       rs373635740       rs373894554       rs373920890       rs374162859       rs374395824       rs374439753       rs374674388       rs374813048       rs375042957       rs375333418       rs375479601       rs375528107       rs375600307       rs375624612       rs375972115       rs375978420       rs376142926       rs376186483       rs376187198       rs376378145       rs376380142       rs376406753       rs376459869       rs376563221       rs376574248       rs376810243       rs376866610       rs376869468       rs376952672       rs376963321       rs377165995       rs377187984       rs377263513       rs377377467       rs377439712       rs377520341       rs398021104       rs398044816       rs527299763       rs527404634       rs527449348       rs527467430       rs527574708       rs527648626       rs527728549       rs527765051       rs527896476       rs528011528       rs528036061       rs528160094       rs528161701       rs528283415       rs528324514       rs528469776       rs528494920       rs528573372       rs528596143       rs528745100       rs528779843       rs528912693       rs528957259       rs529213166       rs529255345       rs529335061       rs529373759       rs529461492       rs529537931       rs529551803       rs529589033       rs529769620       rs529788468       rs529954587       rs529978634       rs530091740       rs530124013       rs530130807       rs530231879       rs530277893       rs530322863       rs530511136       rs530619536       rs530697013       rs530900146       rs530906895       rs530939996       rs530944866       rs530945290       rs531222487       rs531347873       rs531388983       rs531552078       rs531586041       rs531629603       rs531635304       rs531664501       rs531834126       rs531863333       rs532068389       rs532120460       rs532249670       rs532430334       rs532520590       rs532570197       rs532709313       rs532874442       rs532891031       rs533255988       rs533299251       rs533315254       rs533392480       rs533477147       rs533826621       rs533917757       rs533976641       rs534178782       rs534262818       rs534417574       rs534422141       rs534544276       rs534568397       rs534643054       rs534682951       rs535027240       rs535147348       rs535156784       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rs766531792       rs766532967       rs766592126       rs766695912       rs766749639       rs766766771       rs766951079       rs766980005       rs767038020       rs767051886       rs767102083       rs767104974       rs767207673       rs767213525       rs767308119       rs767521571       rs767551203       rs767574570       rs767633294       rs767731640       rs767822991       rs767938818       rs767972223       rs767981036       rs767990189       rs768084694       rs768146867       rs768398088       rs768537738       rs768611166       rs768620397       rs768655166       rs768708499       rs768735353       rs768763593       rs768930508       rs768938790       rs769112911       rs769124586       rs769177443       rs769177666       rs769191485       rs769355412       rs769365015       rs769443360       rs769540932       rs769600688       rs769744325       rs769890741       rs769955878       rs770070521       rs770176291       rs770259667       rs770316572       rs770391051       rs770493024       rs770691333       rs770825732       rs770842458       rs770857292       rs770869596       rs770909103       rs770975785       rs770995082       rs771052473       rs771246357       rs771248214       rs771265537       rs771299604       rs771387920       rs771394878       rs771443005       rs771520960       rs771551713       rs771553529       rs771593148       rs771713691       rs771817509       rs771861456       rs771907622       rs771926532       rs771995998       rs772049057       rs772051639       rs772081449       rs772138601       rs772185784       rs772214936       rs772287244       rs772385623       rs772392072       rs772394101       rs772470547       rs772616072       rs772684767       rs772738002       rs772809882       rs772985485       rs772985946       rs773081417       rs773125955       rs773150705       rs773166556       rs773168362       rs773175319       rs773203954       rs773415214       rs773504316       rs773546396       rs773694191       rs773749996       rs773830752       rs773838506       rs773875544       rs773884149       rs773926403       rs774212828       rs774222018       rs774283460       rs774318450       rs774352133       rs774388104       rs774437375       rs774566679       rs774574207       rs774764449       rs774856230       rs774939653       rs774940987       rs774994848       rs775056600       rs775126974       rs775212975       rs775239286       rs775310094       rs775357703       rs775386741       rs775390181       rs775401110       rs775460878       rs775516448       rs775567886       rs775629834       rs775740621       rs775762781       rs775802135       rs775838120       rs775911109       rs776084638       rs776086015       rs776090911       rs776144253       rs776274311       rs776320770       rs776361314       rs776361931       rs776470575       rs776495484       rs776525047       rs776546854       rs776577530       rs776726337       rs776753979       rs776781876       rs776841061       rs776914173       rs776973911       rs777101668       rs777154983       rs777155036       rs777231819       rs777375870       rs777425909       rs777473977       rs777475728       rs777531383       rs777584914       rs777629471       rs777811863       rs777946684       rs778040742       rs778093110       rs778232401       rs778251016       rs778438398       rs778493072       rs778529198       rs778582088       rs778593081       rs778593894       rs778659367       rs778676077       rs778732471       rs778768025       rs778770856       rs778849939       rs779035937       rs779090932       rs779124226       rs779208167       rs779300095       rs779387266       rs779459111       rs779460272       rs779467476       rs779641843       rs779693957       rs779700187       rs779740196       rs779753593       rs779766676       rs779783782       rs779799787       rs779874408       rs780019986       rs780028842       rs780084630       rs780147286       rs780200643       rs780355192       rs780380915       rs780424797       rs780440026       rs780507959       rs780563787       rs780575788       rs780606160       rs780681186       rs780842074       rs780843452       rs780898456       rs781002376       rs781045247       rs781118184       rs781147636       rs781218570       rs781234233       rs781312039       rs781367202       rs781389743       rs781456563       rs781529188       rs781635534       rs869106337      

RASAL1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTTCAAGAAGCGCTACGTC
59
ATGGAGTGACACATCTGCC
60
TTAGCCGTGTCTTTGAGGAG
60
CAGGTACTTCACATCCGGG
60
CTTCAAGAAGCGCTACGTC
59
CCTCCAGTAATTTCAGCCTG
58
CTTCAAGAAGCGCTACGTC
59
ATGGAGTGACACATCTGCC
60
TCGAGAAGGCTATCTGCTG
59
AGTGACACATCTGCCACTC
60
TAGCCGTGTCTTTGAGGAG
59
CAGGTACTTCACATCCGGG
60
GACATCTCTGGCACATCTG
58
AGTCTTCTTGATGGTTGAGG
57
ACTGGATCCTGATGCTGAG
59
CCTCCAGTAATTTCAGCCTG
58
CCAGAGACATCTCTGGCAC
60
TCTTGATGGTTGAGGTCTCC
59
TGAAGGTACGCCTGATTGAG
60
CTAGCAGTGTCCTCCTCTG
59
      尚未收录相关数据

RASAL1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

RASAL1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0000165
O95294(UniProtKB)
TAS
GO:0005096
O95294(UniProtKB)
IEA
GO:0005543
O95294(UniProtKB)
TAS
GO:0005829
O95294(UniProtKB)
IDA
GO:0005829
O95294(UniProtKB)
TAS
GO:0005829
O95294(UniProtKB)
TAS
GO:0007165
O95294(UniProtKB)
TAS
GO:0031235
O95294(UniProtKB)
IBA
GO:0043547
O95294(UniProtKB)
IEA
GO:0046580
O95294(UniProtKB)
IBA
GO:0046872
O95294(UniProtKB)
IEA
GO:1903861
O95294(UniProtKB)
IDA
GO:0005886
O95294(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控RASAL1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Kidney Diseases 0.12 1 0 CTD_human
Colorectal Neoplasms 0.002995792 1 0 BeFree_LHGDN
Malignant neoplasm of stomach 0.001357209 5 0 BeFree
Carcinogenesis 0.001357209 5 0 BeFree
Stomach Carcinoma 0.001357209 5 0 BeFree
Adenoma 0.000542884 2 0 BeFree
Malignant neoplasm of thyroid 0.000542884 2 0 BeFree
Colonic Neoplasms 0.000542884 2 0 BeFree
Follicular thyroid carcinoma 0.000542884 2 0 BeFree
Anaplastic thyroid carcinoma 0.000542884 2 0 BeFree
Thyroid carcinoma 0.000542884 2 0 BeFree
Adenocarcinoma 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Hamartoma Syndrome, Multiple 0.000271442 1 0 BeFree
Stomach Neoplasms 0.000271442 1 0 BeFree
Thyroid Neoplasm 0.000271442 1 0 BeFree
Papillary thyroid carcinoma 0.000271442 1 0 BeFree
Gastric Adenocarcinoma 0.000271442 1 0 BeFree
Chronic Kidney Insufficiency 0.000271442 1 0 BeFree
Cardiac fibrosis 0.000271442 1 0 BeFree
Xenograft Model 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Chronic Kidney Diseases 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
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