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The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是GAP1家族GTP酶激活蛋白质的成员。这些蛋白质会刺激正常RAS p21蛋白的GTP酶活性而不是它的致癌对应。作为RAS功能的抑制剂,蛋白质增强导致的RAS的非活性的GDP结合形式,从而允许细胞增殖和分化的控制RAS蛋白的弱内在GTP酶活性。这个特定的家庭成员包含它们RasGAP蛋白质GAP1亚科的特性,但是,与此相反的其他GAP1家族成员结构域,此蛋白质的强烈和选择性在内分泌组织中表达。编码不同亚型选择性剪接转录变异体已被描述[按RefSeq的,2010年7月提供]
RASAL1基因(以及对应的蛋白质)的细胞分布位置:
RASAL1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Kidney Diseases | 0.12 | 1 | 0 | CTD_human |
| Colorectal Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Malignant neoplasm of stomach | 0.001357209 | 5 | 0 | BeFree |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Stomach Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Adenoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of thyroid | 0.000542884 | 2 | 0 | BeFree |
| Colonic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Follicular thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Anaplastic thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hamartoma Syndrome, Multiple | 0.000271442 | 1 | 0 | BeFree |
| Stomach Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Insufficiency | 0.000271442 | 1 | 0 | BeFree |
| Cardiac fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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