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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  氨酰tRNA合成酶由它们的同源氨基酸催化的tRNA的氨酰化。因为它们在联用包含在tRNA的核苷酸三联氨基酸核心作用,氨酰tRNA合成酶被认为是出现在进化第一蛋白中。精氨酰tRNA合成酶属于I类氨酰tRNA合成家族。 [由RefSeq的,2008年7月提供]
RARS基因(以及对应的蛋白质)的细胞分布位置:
RARS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
LEUKODYSTROPHY, HYPOMYELINATING, 9 | 0.24 | 1 | 0 | ORPHANET_UNIPROT |
IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
Refractory anaemia with excess blasts | 0.00434307 | 16 | 0 | BeFree |
Refractory anemias | 0.001900093 | 7 | 0 | BeFree |
Refractory anemia, without ringed sideroblasts, without excess blasts | 0.001900093 | 7 | 0 | BeFree |
Leukemia, Myelomonocytic, Chronic | 0.001628651 | 6 | 0 | BeFree |
Refractory anemia with ringed sideroblasts | 0.001628651 | 6 | 2 | BeFree |
Thrombocytosis | 0.000814326 | 3 | 0 | BeFree |
Anemia | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Monosomy | 0.000542884 | 2 | 0 | BeFree |
Thrombocythemia, Essential | 0.000542884 | 2 | 2 | BeFree |
Juvenile Myelomonocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
5q-syndrome | 0.000542884 | 2 | 0 | BeFree |
Myelodysplastic Syndrome with Isolated del(5q) | 0.000542884 | 2 | 0 | BeFree |
Myelodysplastic-Myeloproliferative Diseases | 0.000542884 | 2 | 0 | BeFree |
Refractory anemia with excess blasts II | 0.000542884 | 2 | 0 | BeFree |
Chromosome 5, trisomy 5q | 0.000542884 | 2 | 0 | BeFree |
Primary Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
Aplastic Anemia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 4 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Myelofibrosis | 0.000271442 | 1 | 0 | BeFree |
Myeloproliferative disease | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Congenital pontocerebellar hypoplasia | 0.000271442 | 1 | 0 | BeFree |
Secondary acquired sideroblastic anemia | 0.000271442 | 1 | 0 | BeFree |
secondary acute myeloid leukemia | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 4 | BeFree |
Pontoneocerebellar hypoplasia | 0.000271442 | 1 | 0 | BeFree |
Pontocerebellar Hypoplasia Type 6 | 0.000271442 | 1 | 0 | BeFree |
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