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This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
[中文简述(自动翻译):]  这个基因代表了核维甲酸受体。所编码的蛋白质,视黄酸受体α,调节转录的配体依赖性。该基因有牵连的发育,分化,凋亡,granulopoeisis和转录时钟基因的调节。该位点和其他几个位点之间的易位已与急性早幼粒细胞白血病有关。另外剪接转录变体也发现了该基因位点。[由RefSeq的,2010年9月提供]
RARA基因(以及对应的蛋白质)的细胞分布位置:
RARA基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Acute Promyelocytic Leukemia | 0.347243502 | 399 | 1 | BeFree_CTD_human_LHGDN_ORPHANET |
Mammary Neoplasms | 0.127077352 | 9 | 0 | BeFree_CTD_human_LHGDN |
Liver carcinoma | 0.121085767 | 5 | 0 | BeFree_CTD_human |
Phyllodes Tumor | 0.12 | 1 | 0 | CTD_human |
Neoplasms, Second Primary | 0.12 | 1 | 0 | CTD_human |
Sciatic Neuropathy | 0.12 | 1 | 0 | CTD_human |
Fibroadenoma | 0.12 | 1 | 0 | CTD_human |
Amyotrophic Lateral Sclerosis | 0.08 | 1 | 0 | RGD |
Promyelocytic leukemia | 0.025244094 | 93 | 0 | BeFree |
leukemia | 0.020397866 | 39 | 0 | BeFree_LHGDN |
Leukemia, Myelocytic, Acute | 0.014396351 | 43 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.009229024 | 34 | 2 | BeFree |
Breast Carcinoma | 0.008957582 | 33 | 2 | BeFree |
Leukemogenesis | 0.006243163 | 23 | 0 | BeFree |
Leukoencephalopathy, Progressive Multifocal | 0.005428837 | 20 | 0 | BeFree |
Cleft Lip | 0.005005506 | 3 | 0 | BeFree_GAD |
Cleft Palate | 0.005005506 | 3 | 0 | BeFree_GAD |
Squamous cell carcinoma | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Myeloid Leukemia | 0.003528744 | 13 | 0 | BeFree |
Prostatic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Carcinogenesis | 0.002442977 | 9 | 0 | BeFree |
Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
Liver Cirrhosis | 0.002367032 | 1 | 0 | GAD |
Hepatopulmonary Syndrome | 0.002367032 | 1 | 0 | GAD |
Neoplasm, Residual | 0.001900093 | 7 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.001357209 | 5 | 1 | BeFree |
melanoma | 0.001357209 | 5 | 1 | BeFree |
Stomach Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Congenital chromosomal disease | 0.001085767 | 4 | 0 | BeFree |
Acute lymphocytic leukemia | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001085767 | 4 | 0 | BeFree |
Myeloproliferative disease | 0.001085767 | 4 | 0 | BeFree |
Neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Cervix carcinoma | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Non-Neoplastic Disorder | 0.001085767 | 4 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Rheumatoid Arthritis | 0.000814326 | 3 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000814326 | 3 | 0 | BeFree |
Nephroblastoma | 0.000814326 | 3 | 0 | BeFree |
Schizophrenia | 0.000814326 | 3 | 0 | BeFree |
Acute leukemia | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Blood Coagulation Disorders | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 1 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Measles | 0.000542884 | 2 | 0 | BeFree |
Lipoid nephrosis | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma | 0.000542884 | 2 | 0 | BeFree |
Trisomy | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
Isochromosomes | 0.000542884 | 2 | 0 | BeFree |
Spastic syndrome | 0.000542884 | 2 | 0 | BeFree |
Hypergranular promyelocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Osteosarcoma of bone | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Refractory cancer | 0.000542884 | 2 | 0 | BeFree |
Smith-Magenis syndrome | 0.000542884 | 2 | 0 | BeFree |
Glomerulonephritis, Minimal Change | 0.000542884 | 2 | 0 | BeFree |
Acute Disease | 0.000271442 | 1 | 0 | BeFree |
Alcoholic Intoxication, Chronic | 0.000271442 | 1 | 0 | BeFree |
Asthma | 0.000271442 | 1 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Bipolar Disorder | 0.000271442 | 1 | 0 | BeFree |
Borderline Personality Disorder | 0.000271442 | 1 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Cholestasis | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Keratoderma, Palmoplantar, Diffuse | 0.000271442 | 1 | 0 | BeFree |
Palmoplantar Keratosis | 0.000271442 | 1 | 0 | BeFree |
Lymphoid leukemia | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Microcephaly | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Schistosomiasis | 0.000271442 | 1 | 0 | BeFree |
Seminoma | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Varicocele | 0.000271442 | 1 | 0 | BeFree |
AIDS-Associated Nephropathy | 0.000271442 | 1 | 0 | BeFree |
B-Cell Lymphomas | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Follicular thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Multiple malignancy | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Refractory anemia with excess blasts I | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Renal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Mammary Tumorigenesis | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
47, XYY syndrome | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
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