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The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]
[中文简述(自动翻译):]  由该基因编码的蛋白质是RAD51蛋白家族的一个成员。 RAD51家族成员是进化保守的用于通过同源重组DNA修复必需的蛋白质。这种蛋白已经显示出,以形成与家人RAD51C,其进一步与其他家族成员,例如RAD51,XRCC2和XRCC3相互作用的稳定二聚体。该基因的过度表达被发现会引起细胞周期G1期延迟和细胞凋亡,这表明该蛋白在感测DNA损伤的作用。至少三个可变剪接转录物变体编码不同同种型已被观察到。该位点和高迁移率族AT钩2(HMGA2,GeneID 8091)之间的重组已在子宫平滑肌瘤被观察到。 [由RefSeq的,2011年7月提供]
RAD51B基因(以及对应的蛋白质)的细胞分布位置:
RAD51B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Malignant neoplasm of breast | 0.132453989 | 15 | 26 | BeFree_GAD_GWASCAT |
| Mammary Neoplasms | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Age related macular degeneration | 0.120542884 | 3 | 2 | BeFree_GWASCAT |
| Rheumatoid Arthritis | 0.120271442 | 2 | 1 | BeFree_GWASCAT |
| Primary biliary cirrhosis | 0.12 | 1 | 1 | GWASCAT |
| Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Breast Neoplasms, Male | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of prostate | 0.12 | 1 | 1 | GWASCAT |
| Hamartoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Breast Carcinoma | 0.002985861 | 11 | 23 | BeFree |
| Glioma | 0.002638474 | 1 | 0 | BeFree_GAD |
| Atrial Fibrillation | 0.002367032 | 1 | 3 | GAD |
| Brain Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Biliary cirrhosis | 0.002367032 | 1 | 1 | GAD |
| Animal Mammary Neoplasms | 0.002367032 | 1 | 0 | GAD |
| Multiple Sclerosis | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Uterine Fibroids | 0.001628651 | 6 | 0 | BeFree |
| Fibroid Tumor | 0.001085767 | 4 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Chondroid Hamartoma | 0.000542884 | 2 | 0 | BeFree |
| Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
| Macular degeneration | 0.000271442 | 1 | 1 | BeFree |
| Meigs Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Thymoma | 0.000271442 | 1 | 0 | BeFree |
| Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of Male Breast | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of male breast | 0.000271442 | 1 | 0 | BeFree |
| Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 3 | BeFree |
| Perivascular Epithelioid Cell Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Mammographic Density | 0.000271442 | 1 | 0 | BeFree |
| Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 6 | BeFree |
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