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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一个成员。的PTPs已知是信令调节多种细胞过程,包括细胞生长,分化,有丝分裂周期,和致癌性转化的分子。此PTP具有一个胞外区,一个跨膜区和两个串联的催化结构域,并因此代表了受体型PTP。胞外区含有meprin-A5抗原PTP亩(MAM)结构域,Ig样结构域和四个纤连蛋白III型样重复。此PTP已经示出通过与上相邻小区此PTP的另一分子的相互作用介导的细胞 - 细胞聚集。此PTP可以与支架蛋白RACK1 / GNB2L1,这可能是必需的下游信号响应于细胞 - 细胞粘附相互作用。选择性剪接结果编码不同亚型多重成绩单。 [由RefSeq的,2008年7月提供]
PTPRM基因(以及对应的蛋白质)的细胞分布位置:
PTPRM基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 2 | GAD |
| Lupus Erythematosus, Systemic | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Fibrinogen Adverse Event | 0.002367032 | 1 | 1 | GAD |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Multiple Sclerosis | 0.000271442 | 1 | 11 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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