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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
[中文简述(自动翻译):]  由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一个成员。的PTPs已知是信令调节多种细胞过程,包括细胞生长,分化,有丝分裂,和致癌性转化的分子。此PTP包含一个细胞外结构域,单个跨膜片段和两个串联胞质内催化域,并因此被归类为受体型PTP。此PTP已被证明是T形的一个基本调节剂和B细胞抗原受体信号传导。它的功能或者通过与抗原受体复合物的组分的直接相互作用,或通过激活对抗原受体信号所需的各种Src家族激酶。此PTP也抑制JAK激酶,因此作为细胞因子受体信号传导的调节器。 ,已经报道了这个基因的可变剪接转录物变体,其编码不同同种型。 [由RefSeq的,2012年6月提供]
PTPRC基因(以及对应的蛋白质)的细胞分布位置:
PTPRC基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Severe Combined Immunodeficiency, Autosomal Recessive, T Cell Negative, B Cell Positive, NK Cell Positive | 0.36 | 0 | 1 | CLINVAR_CTD_human_ORPHANET |
| Multiple Sclerosis | 0.146532747 | 15 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Rheumatoid Arthritis | 0.130553895 | 9 | 1 | BeFree_CTD_human_GAD |
| Hepatitis C | 0.125362824 | 2 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Ulcerative Colitis | 0.12 | 1 | 1 | GWASCAT |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Retinal Diseases | 0.12 | 1 | 0 | CTD_human |
| HEPATITIS C VIRUS, SUSCEPTIBILITY TO | 0.12 | 0 | 0 | CLINVAR |
| Lupus Erythematosus, Systemic | 0.082638474 | 2 | 0 | BeFree_GAD_MGD |
| Neointima | 0.08 | 1 | 0 | RGD |
| HIV Infections | 0.011073035 | 14 | 0 | BeFree_GAD_LHGDN |
| Multiple Myeloma | 0.010877538 | 22 | 0 | BeFree_LHGDN |
| Hepatitis, Autoimmune | 0.007729856 | 2 | 0 | BeFree_GAD_LHGDN |
| Graves Disease | 0.00764398 | 3 | 0 | BeFree_GAD |
| Systemic Scleroderma | 0.005634266 | 2 | 0 | BeFree_GAD_LHGDN |
| Diabetes Mellitus, Insulin-Dependent | 0.00554839 | 4 | 0 | BeFree_GAD |
| Infection | 0.0054487 | 2 | 0 | LHGDN |
| Paraparesis | 0.004734064 | 2 | 0 | GAD |
| Severe Combined Immunodeficiency | 0.004267125 | 8 | 0 | BeFree_GAD |
| Leber Congenital Amaurosis | 0.003257302 | 12 | 0 | BeFree |
| Inflammatory Bowel Diseases | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Myasthenia Gravis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Lymphoma | 0.002985861 | 11 | 0 | BeFree |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Pathological Dilatation | 0.00272435 | 1 | 0 | LHGDN |
| Fetal Distress | 0.00272435 | 1 | 0 | LHGDN |
| Myocardial Infarction | 0.00272435 | 1 | 0 | LHGDN |
| Alzheimer's Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
| Hepatitis B | 0.002638474 | 2 | 0 | BeFree_GAD |
| Leukemia, Myelocytic, Acute | 0.002442977 | 9 | 0 | BeFree |
| Ascariasis | 0.002367032 | 1 | 0 | GAD |
| Hepatitis, Chronic | 0.002367032 | 1 | 0 | GAD |
| Lymphopenia | 0.002367032 | 1 | 0 | GAD |
| Lupus Erythematosus | 0.002367032 | 1 | 0 | GAD |
| Chronic Lymphocytic Leukemia | 0.002171535 | 8 | 0 | BeFree |
| B-Cell Lymphomas | 0.001900093 | 7 | 0 | BeFree |
| Neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
| Central neuroblastoma | 0.001628651 | 6 | 0 | BeFree |
| leukemia | 0.001085767 | 4 | 0 | BeFree |
| Precursor B-cell lymphoblastic leukemia | 0.001085767 | 4 | 0 | BeFree |
| Graft-vs-Host Disease | 0.000814326 | 3 | 0 | BeFree |
| Immunologic Deficiency Syndromes | 0.000814326 | 3 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
| Lymphohistiocytosis, Hemophagocytic | 0.000814326 | 3 | 0 | BeFree |
| Reticulosarcoma | 0.000814326 | 3 | 0 | BeFree |
| Monoclonal Gammopathy of Undetermined Significance | 0.000814326 | 3 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000814326 | 3 | 0 | BeFree |
| Autoimmune Diseases | 0.000542884 | 2 | 1 | BeFree |
| Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
| melanoma | 0.000542884 | 2 | 0 | BeFree |
| Plasmacytoma | 0.000542884 | 2 | 0 | BeFree |
| Granulocytic Sarcoma | 0.000542884 | 2 | 0 | BeFree |
| Ki-1+ Anaplastic Large Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm, Residual | 0.000542884 | 2 | 0 | BeFree |
| Solid tumour | 0.000542884 | 2 | 0 | BeFree |
| Senile Plaques | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Hematologic Neoplasms | 0.000542884 | 2 | 0 | BeFree |
| Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Classical Hodgkin's Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Plasma Cell Neoplasm | 0.000542884 | 2 | 0 | BeFree |
| Plaque, Amyloid | 0.000542884 | 2 | 0 | BeFree |
| AIDS Dementia Complex | 0.000271442 | 1 | 0 | BeFree |
| Aneurysm | 0.000271442 | 1 | 0 | BeFree |
| Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Cholestasis | 0.000271442 | 1 | 0 | BeFree |
| Bronchitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Colitis | 0.000271442 | 1 | 0 | BeFree |
| Common Variable Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Conjunctival Diseases | 0.000271442 | 1 | 0 | BeFree |
| Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
| Infection by Cryptococcus neoformans | 0.000271442 | 1 | 0 | BeFree |
| Mental Depression | 0.000271442 | 1 | 0 | BeFree |
| Diabetes | 0.000271442 | 1 | 0 | BeFree |
| Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
| Hemangioma | 0.000271442 | 1 | 0 | BeFree |
| Immune System Diseases | 0.000271442 | 1 | 0 | BeFree |
| Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Lymphoid leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000271442 | 1 | 0 | BeFree |
| Lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
| Waldenstrom Macroglobulinemia | 0.000271442 | 1 | 0 | BeFree |
| Meningioma | 0.000271442 | 1 | 0 | BeFree |
| Myelodysplasia | 0.000271442 | 1 | 0 | BeFree |
| Myocarditis | 0.000271442 | 1 | 0 | BeFree |
| Nasal Polyps | 0.000271442 | 1 | 0 | BeFree |
| Preleukemia | 0.000271442 | 1 | 0 | BeFree |
| Psychotic Disorders | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Respiratory Syncytial Virus Infections | 0.000271442 | 1 | 0 | BeFree |
| Retinal Degeneration | 0.000271442 | 1 | 0 | BeFree |
| Retinitis Pigmentosa | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Thromboangiitis Obliterans | 0.000271442 | 1 | 0 | BeFree |
| Thymoma | 0.000271442 | 1 | 0 | BeFree |
| Immunoblastic Large-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Amyloid Angiopathy | 0.000271442 | 1 | 0 | BeFree |
| Polymyositis | 0.000271442 | 1 | 0 | BeFree |
| Hamman-Rich syndrome | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
| Migraine Disorders | 0.000271442 | 1 | 0 | BeFree |
| Strawberry nevus of skin | 0.000271442 | 1 | 0 | BeFree |
| Mastocytosis, Systemic | 0.000271442 | 1 | 1 | BeFree |
| X-linked agammaglobulinemia | 0.000271442 | 1 | 0 | BeFree |
| Memory impairment | 0.000271442 | 1 | 0 | BeFree |
| Inclusion Body Myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
| X-linked hypogammaglobulinemia | 0.000271442 | 1 | 0 | BeFree |
| Amyloidosis, familial visceral | 0.000271442 | 1 | 0 | BeFree |
| Familial Cerebral Amyloid Angiopathy | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
| stage, neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor necrosis | 0.000271442 | 1 | 0 | BeFree |
| Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
| Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Transplant glomerulopathy | 0.000271442 | 1 | 0 | BeFree |
| Trisomy 12 | 0.000271442 | 1 | 0 | BeFree |
| Chromosome 8, trisomy | 0.000271442 | 1 | 0 | BeFree |
| Low grade B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Precursor B-lymphoblastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Renal ischaemia | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
| Primary Effusion Lymphoma | 0.000271442 | 1 | 0 | BeFree |
| T-cell/histiocyte rich large B-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Mesenchymal Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cerebral Amyloid Angiopathy, Hereditary | 0.000271442 | 1 | 0 | BeFree |
| Astler-Coller B1 Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| AURAL ATRESIA, CONGENITAL | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| T-Lymphocytopenia | 0.000271442 | 1 | 0 | BeFree |
| Plasmablastic lymphoma | 0.000271442 | 1 | 0 | BeFree |
| Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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