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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一个成员。的PTPs已知是信令调节多种细胞过程,包括细胞生长,分化,有丝分裂周期,和致癌性转化的分子。此PTP的N末端部分包含两个串联的Src同源(SH2)域,它作为蛋白质磷酸酪氨酸结合结构域,并介导此PTP与其底物的相互作用。此PTP主要在造血细胞,并用作在造血细胞中多种信号传导途径的重要调节表达。此PTP已显示与交互,和去磷酸化参与造血细胞信号磷酸 - 蛋白质的宽光谱。 ,已经报道了这个基因的多个可变剪接变体,其编码不同同种型。 [由RefSeq的,2008年7月提供]
PTPN6基因(以及对应的蛋白质)的细胞分布位置:
PTPN6基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Calcinosis | 0.12 | 1 | 0 | CTD_human |
Heart valve disease | 0.12 | 1 | 0 | CTD_human |
Respiratory Hypersensitivity | 0.12 | 1 | 0 | CTD_human |
Lymphoma | 0.007891677 | 9 | 0 | BeFree_LHGDN |
leukemia | 0.007620235 | 8 | 0 | BeFree_LHGDN |
Lymphoma, T-Cell, Cutaneous | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Multiple Myeloma | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Multiple Sclerosis | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Sezary Syndrome | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Epstein-Barr Virus Infections | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Anemia | 0.00272435 | 1 | 0 | LHGDN |
Adult T-Cell Lymphoma/Leukemia | 0.00272435 | 1 | 0 | LHGDN |
Medullary carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Lupus Erythematosus, Systemic | 0.002638474 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Liver carcinoma | 0.001900093 | 7 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001628651 | 6 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.001357209 | 5 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Autoimmune Diseases | 0.000814326 | 3 | 0 | BeFree |
Polycythemia Vera | 0.000814326 | 3 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Leukemogenesis | 0.000814326 | 3 | 0 | BeFree |
Asthma | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Diabetes | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
Hyperinsulinism | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Mitral Valve Stenosis | 0.000542884 | 2 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.000542884 | 2 | 0 | BeFree |
Myeloproliferative disease | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Dermatologic disorders | 0.000542884 | 2 | 0 | BeFree |
B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Juvenile Myelomonocytic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Helicobacter pylori infection | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Neutrophilic dermatosis | 0.000542884 | 2 | 0 | BeFree |
Inflammatory disorder | 0.000542884 | 2 | 0 | BeFree |
Primary Effusion Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000542884 | 2 | 0 | BeFree |
Epithelioma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Cancer | 0.000542884 | 2 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Burkitt Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Dermatitis, Atopic | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Eczema | 0.000271442 | 1 | 0 | BeFree |
Filarial Elephantiases | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Histiocytosis, Langerhans-Cell | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
Leishmaniasis | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
Lymphohistiocytosis, Hemophagocytic | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Melioidosis | 0.000271442 | 1 | 0 | BeFree |
Myopathy | 0.000271442 | 1 | 0 | BeFree |
Mycoplasma Infections | 0.000271442 | 1 | 0 | BeFree |
Myositis | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Psoriasis | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Pyoderma Gangrenosum | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Mastocytosis, Systemic | 0.000271442 | 1 | 0 | BeFree |
Pseudolymphoma | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Non-small cell lung cancer stage I | 0.000271442 | 1 | 0 | BeFree |
Congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
X-Linked Lymphoproliferative Disorder | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
Philadelphia chromosome positive | 0.000271442 | 1 | 0 | BeFree |
Breast adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic inflammatory disorder | 0.000271442 | 1 | 0 | BeFree |
Human T-cell lymphotropic virus 1 infection | 0.000271442 | 1 | 0 | BeFree |
Severe congenital neutropenia | 0.000271442 | 1 | 0 | BeFree |
CAMPOMELIC DYSPLASIA | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Leukemia, B-Cell | 0.000271442 | 1 | 0 | BeFree |
Infection - suppurative | 0.000271442 | 1 | 0 | BeFree |
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