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This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
[中文简述(自动翻译):]  这是编码催化arachinodate的前列腺素的转化类似的酶的两个基因中的一个。所编码的蛋白质调节在内皮细胞的血管生成,并且由非类固醇抗炎药如阿司匹林抑制。根据它的功能既用作环氧合酶和过氧化物酶的能力,所编码的蛋白质已被鉴定为一个兼职蛋白质。蛋白质可以肿瘤进展过程中促进细胞增殖。选择性剪接结果在多个抄本变形。 [由RefSeq的,2014年1月提供]
PTGS1基因(以及对应的蛋白质)的细胞分布位置:
PTGS1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Esophageal Neoplasms | 0.2 | 2 | 0 | CTD_human_RGD |
Hyperalgesia | 0.2 | 2 | 0 | CTD_human_RGD |
Gastric ulcer | 0.1289015 | 7 | 1 | BeFree_CTD_human_GAD_LHGDN |
Flushing | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Drug Allergy | 0.12 | 1 | 0 | CTD_human |
Heart failure | 0.12 | 1 | 0 | CTD_human |
Intestinal Polyps | 0.12 | 2 | 0 | CTD_human |
Kidney Failure, Chronic | 0.12 | 1 | 0 | CTD_human |
Ovarian Cysts | 0.12 | 1 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Reperfusion Injury | 0.12 | 1 | 0 | CTD_human |
Sleep Deprivation | 0.12 | 1 | 0 | CTD_human |
Bronchial Hyperreactivity | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Alzheimer's Disease | 0.08617715 | 7 | 0 | BeFree_GAD_LHGDN_RGD |
Pre-Eclampsia | 0.082367032 | 1 | 0 | GAD_MGD |
Renal Cell Carcinoma | 0.080271442 | 2 | 0 | BeFree_RGD |
Ulcerative Colitis | 0.080271442 | 2 | 0 | BeFree_RGD |
anaphylaxis | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Experimental Autoimmune Encephalomyelitis | 0.08 | 1 | 0 | RGD |
Glioblastoma | 0.08 | 1 | 0 | RGD |
Hepatic Encephalopathy | 0.08 | 1 | 0 | RGD |
Hypertension, Renovascular | 0.08 | 1 | 0 | RGD |
Polycystic Kidney Diseases | 0.08 | 1 | 0 | RGD |
Neuritis, Autoimmune, Experimental | 0.08 | 1 | 0 | RGD |
Pain | 0.08 | 2 | 0 | RGD |
gliosarcoma | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
Colorectal Cancer | 0.010901282 | 16 | 3 | BeFree_GAD |
Adenoma | 0.010725648 | 4 | 0 | BeFree_GAD_LHGDN |
Colorectal Neoplasms | 0.009825446 | 4 | 0 | GAD_LHGDN |
Peptic Ulcer | 0.008458305 | 6 | 3 | BeFree_GAD |
Myocardial Infarction | 0.008001298 | 4 | 0 | BeFree_GAD_LHGDN |
Stomach Neoplasms | 0.007458414 | 3 | 0 | GAD_LHGDN |
Inflammation | 0.007101096 | 3 | 0 | GAD |
Premature Birth | 0.007101096 | 3 | 0 | GAD |
Squamous cell carcinoma | 0.00680591 | 6 | 0 | BeFree_LHGDN |
Asthma | 0.006720033 | 6 | 0 | BeFree_GAD_LHGDN |
Cardiovascular Diseases | 0.00617715 | 4 | 0 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.006091273 | 6 | 1 | BeFree_GAD |
Head and Neck Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
Dyspepsia | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Atherosclerosis | 0.005276948 | 4 | 0 | BeFree_GAD |
Infection | 0.005091382 | 2 | 0 | GAD_LHGDN |
Helicobacter Infections | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of breast | 0.003995683 | 6 | 0 | BeFree_GAD |
Adenocarcinoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Epithelial ovarian cancer | 0.003724241 | 6 | 0 | BeFree_GAD |
Rheumatoid Arthritis | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Malignant neoplasm of ovary | 0.003452799 | 5 | 0 | BeFree_GAD |
Neoplasm Metastasis | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Colorectal Carcinoma | 0.003257302 | 12 | 0 | BeFree |
Carcinogenesis | 0.003257302 | 12 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.003181358 | 4 | 0 | BeFree_GAD |
Acute Promyelocytic Leukemia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Coronary Arteriosclerosis | 0.002909916 | 2 | 0 | BeFree_GAD |
Schizophrenia | 0.002909916 | 3 | 0 | BeFree_GAD |
Coronary Artery Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Gastritis | 0.00272435 | 1 | 0 | LHGDN |
Hepatitis | 0.00272435 | 1 | 0 | LHGDN |
Hyperlipidemia | 0.00272435 | 1 | 0 | LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Lupus Nephritis | 0.00272435 | 1 | 0 | LHGDN |
Lyme Disease | 0.00272435 | 1 | 0 | LHGDN |
Myositis | 0.00272435 | 1 | 0 | LHGDN |
Thrombosis | 0.00272435 | 1 | 0 | LHGDN |
Medullary carcinoma | 0.00272435 | 1 | 0 | LHGDN |
ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Chronic Obstructive Airway Disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Precancerous Conditions | 0.002638474 | 2 | 0 | BeFree_GAD |
Acute Coronary Syndrome | 0.002638474 | 2 | 0 | BeFree_GAD |
Abdominal Pain | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Colonic Polyps | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Cystic Fibrosis | 0.002367032 | 1 | 0 | GAD |
Duodenal Ulcer | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
Stomach Diseases | 0.002367032 | 1 | 0 | GAD |
Ulcer | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of lung | 0.002367032 | 1 | 0 | GAD |
Atrophic | 0.002367032 | 1 | 0 | GAD |
Metabolic Syndrome X | 0.002367032 | 1 | 0 | GAD |
ASPIRIN RESISTANCE | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Ovarian Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Colon Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Breast Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Malignant tumor of colon | 0.001357209 | 5 | 0 | BeFree |
Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
Ischemic stroke | 0.001357209 | 5 | 8 | BeFree |
Ischemic Cerebrovascular Accident | 0.001357209 | 5 | 8 | BeFree |
Cyst | 0.001085767 | 4 | 0 | BeFree |
Nasal Polyps | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of bladder | 0.001085767 | 4 | 0 | BeFree |
Adenoma of large intestine | 0.001085767 | 4 | 0 | BeFree |
Arthritis | 0.000814326 | 3 | 0 | BeFree |
Coronary heart disease | 0.000814326 | 3 | 0 | BeFree |
Hypertensive disease | 0.000814326 | 3 | 0 | BeFree |
Cervix carcinoma | 0.000814326 | 3 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000814326 | 3 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Acidosis, Lactic | 0.000542884 | 2 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Rectal Carcinoma | 0.000542884 | 2 | 6 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of cervix | 0.000542884 | 2 | 0 | BeFree |
Pulmonary Hypertension | 0.000542884 | 2 | 0 | BeFree |
Arthropathy | 0.000542884 | 2 | 0 | BeFree |
Lung diseases | 0.000542884 | 2 | 0 | BeFree |
Synovitis | 0.000542884 | 2 | 0 | BeFree |
Memory impairment | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cervical Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Hyperplastic Polyp | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of gastrointestinal tract | 0.000542884 | 2 | 0 | BeFree |
Thrombocytosis | 0.000542884 | 2 | 1 | BeFree |
Idiopathic Pulmonary Fibrosis | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
Body Temperature Changes | 0.000271442 | 1 | 0 | BeFree |
Capillaria infection | 0.000271442 | 1 | 0 | BeFree |
Cestode Infections | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 1 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 1 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Echinococcosis | 0.000271442 | 1 | 0 | BeFree |
Eclampsia | 0.000271442 | 1 | 0 | BeFree |
Esophagitis | 0.000271442 | 1 | 0 | BeFree |
Hamartoma | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Creutzfeldt-Jakob disease | 0.000271442 | 1 | 0 | BeFree |
keratoacanthoma | 0.000271442 | 1 | 0 | BeFree |
Leigh Disease | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000271442 | 1 | 0 | BeFree |
Lupus Vulgaris | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Discoid | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
Nose Diseases | 0.000271442 | 1 | 0 | BeFree |
Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
Peutz-Jeghers Syndrome | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Rotavirus Infections | 0.000271442 | 1 | 0 | BeFree |
Scabies | 0.000271442 | 1 | 0 | BeFree |
Ureteral obstruction | 0.000271442 | 1 | 0 | BeFree |
Urinary tract infection | 0.000271442 | 1 | 0 | BeFree |
Virus Diseases | 0.000271442 | 1 | 0 | BeFree |
Polyendocrinopathies, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Polymyositis | 0.000271442 | 1 | 0 | BeFree |
Primary Sj�gren's syndrome | 0.000271442 | 1 | 0 | BeFree |
Adult type dermatomyositis | 0.000271442 | 1 | 0 | BeFree |
Psychological symptom | 0.000271442 | 1 | 5 | BeFree |
Medullary carcinoma of thyroid | 0.000271442 | 1 | 0 | BeFree |
Systemic Inflammatory Response Syndrome | 0.000271442 | 1 | 0 | BeFree |
Chronic respiratory failure | 0.000271442 | 1 | 0 | BeFree |
Cytochrome-c Oxidase Deficiency | 0.000271442 | 1 | 0 | BeFree |
Bleeding ulcer | 0.000271442 | 1 | 2 | BeFree |
Neurocysticercosis | 0.000271442 | 1 | 0 | BeFree |
Glaucoma, Primary Open Angle | 0.000271442 | 1 | 0 | BeFree |
Helicobacter-associated gastritis | 0.000271442 | 1 | 0 | BeFree |
Infection by Thelazia | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus | 0.000271442 | 1 | 0 | BeFree |
Impaired exercise tolerance | 0.000271442 | 1 | 0 | BeFree |
Dysmorphic features | 0.000271442 | 1 | 0 | BeFree |
Sleep Apnea, Obstructive | 0.000271442 | 1 | 0 | BeFree |
Intraocular pressure disorder | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
gastritis h pylori | 0.000271442 | 1 | 0 | BeFree |
temporal pain | 0.000271442 | 1 | 5 | BeFree |
Idiopathic Inflammatory Myopathies | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori infection | 0.000271442 | 1 | 0 | BeFree |
Endothelial dysfunction | 0.000271442 | 1 | 0 | BeFree |
Polyp of large intestine | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular morbidity | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Chronic Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
Myoglobinuria, Recurrent | 0.000271442 | 1 | 0 | BeFree |
Creutzfeldt-Jakob Disease, Sporadic | 0.000271442 | 1 | 0 | BeFree |
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