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The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一个谷胱甘肽依赖性前列腺素E合成酶。该基因的表达已显示由促炎细胞因子白细胞介素1β(IL1B)来诱导。其表达也可通过肿瘤抑制蛋白的TP53诱导,并且可能参与TP53诱导细胞凋亡。在小鼠中敲除的研究表明,该基因可能有助于胶原诱导的关节炎的发病机制,并且在炎症反应介导的急性疼痛。 [由RefSeq的,2008年7月提供]
PTGES基因(以及对应的蛋白质)的细胞分布位置:
PTGES基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Inflammation | 0.207458414 | 5 | 0 | CTD_human_GAD_LHGDN_RGD |
Hydronephrosis | 0.12 | 2 | 0 | CTD_human |
Polyuria | 0.12 | 1 | 0 | CTD_human |
Barrett Esophagus | 0.080271442 | 2 | 0 | BeFree_RGD |
Ischemia | 0.080271442 | 2 | 0 | BeFree_RGD |
Carcinoma, Transitional Cell | 0.08 | 1 | 0 | RGD |
Peptic Esophagitis | 0.08 | 1 | 0 | RGD |
Papilloma | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Osteoarthritis, Knee | 0.08 | 1 | 0 | RGD |
Arthritis, Experimental | 0.08 | 1 | 0 | RGD |
Rheumatoid Arthritis | 0.009258818 | 7 | 0 | BeFree_LHGDN |
Premature Birth | 0.007101096 | 3 | 0 | GAD |
Lung Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Degenerative polyarthritis | 0.004353001 | 7 | 0 | BeFree_LHGDN |
Liver carcinoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Endometriosis | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.003181358 | 3 | 0 | BeFree_GAD |
Astrocytoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Squamous cell carcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Hepatitis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Alzheimer's Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
Carotid Artery Diseases | 0.00272435 | 1 | 0 | LHGDN |
Inflammatory Bowel Diseases | 0.00272435 | 1 | 0 | LHGDN |
Premature Obstetric Labor | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.002638474 | 2 | 0 | BeFree_GAD |
Hypertensive disease | 0.002638474 | 2 | 0 | BeFree_GAD |
Cerebrovascular accident | 0.002638474 | 2 | 0 | BeFree_GAD |
Adenoma | 0.002367032 | 1 | 0 | GAD |
Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
B-Cell Lymphomas | 0.002367032 | 1 | 0 | GAD |
T-Cell Lymphoma | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of ovary | 0.002367032 | 1 | 0 | GAD |
Infection | 0.002367032 | 1 | 0 | GAD |
Carcinogenesis | 0.001900093 | 7 | 0 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Arthritis | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Adjuvant-Induced | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cholangiocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000542884 | 2 | 0 | BeFree |
Arthritis, Collagen-Induced | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Hepatocarcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Breast Diseases | 0.000271442 | 1 | 0 | BeFree |
Cholangitis, Sclerosing | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Periodontitis | 0.000271442 | 1 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Acute onset pain | 0.000271442 | 1 | 0 | BeFree |
Thymic Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Inflammatory pain | 0.000271442 | 1 | 0 | BeFree |
Gastric Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Gasping for breath | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Primary sclerosing cholangitis | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
invasive cancer | 0.000271442 | 1 | 0 | BeFree |
myeloblastosis | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Cerebral Aneurysm | 0.000271442 | 1 | 0 | BeFree |
Adenoma of large intestine | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
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