PTGDS(prostaglandin D2 synthase 21kDa (brain)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

9q34.2-q34.3
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白质是一个谷胱甘肽无关前列腺素D合成酶，其催化前列腺素H 2（PGH 2）转化为postaglandin D2（PGD2）。 PGD?? 2用作神经调节剂，以及在中枢神经系统中的营养因子。 PGD?? 2还参与平滑肌收缩/松弛是血小板聚集的有效抑制剂。该基因是在大脑中优先表达。用转基因小鼠过表达该基因研究表明，这种基因可能也参与非快速眼动睡眠的调节。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PTGDS基因的介绍     Wikipedia数据库中对PTGDS基因的介绍

基因序列

基因序列

PTGDS基因的碱基序列：[NCBI]

基因突变

基因突变

PTGDS基因的碱基突变：           显示全部snp
rs6926       rs13306       rs4880180       rs10735660       rs34012410       rs34216979       rs34273409       rs34491311       rs34858694       rs34920773       rs35125096       rs35240177       rs35253986       rs35578682       rs140542991       rs142373812       rs181560681       rs184296011       rs189729639       rs371768026       rs372650640       rs375751114       rs528880330       rs534460239       rs534699733       rs535212205       rs537586533       rs540839847       rs542619917       rs543720144       rs543781233       rs544101587       rs550851337       rs551846167       rs555127383       rs555460451       rs557696666      
rs563721180       rs565187087       rs569317950       rs571787174       rs572011244       rs577532035       rs867250       rs867251       rs1401556       rs3814500       rs3814501       rs34357564       rs34441576       rs35381185       rs35575741       rs35906327       rs36121634       rs61741469       rs73668379       rs73668380       rs138754391       rs140968973       rs147081224       rs182637095       rs185504307       rs189608598       rs201446095       rs372972120       rs530235405       rs532730319       rs536402279       rs536464106       rs536576857       rs536777710       rs538603045       rs540400848       rs544154019       rs544340048       rs550695659       rs551057416       rs552814802       rs553324363       rs554666498       rs557091883       rs557228738       rs557839532       rs558707100       rs558805313       rs560857057       rs561007335       rs565393431       rs567008475       rs567338726       rs571204887       rs573861539       rs573888581       rs575591377       rs4880179       rs8192608       rs8192609       rs8192610       rs10870153       rs11145961       rs11552177       rs11552179       rs11552181       rs12002504       rs34184410       rs34273088       rs34352781       rs34418873       rs34537447       rs35224565       rs35556170       rs35595808       rs35848246       rs35868383       rs55788930       rs56030643       rs56174366       rs71385791       rs71508883       rs71897337       rs74736427       rs76009291       rs111364556       rs111555120       rs112340647       rs112707644       rs112837615       rs112940392       rs113054896       rs113082819       rs113138925       rs117121325       rs138748301       rs139484335       rs139945276       rs140155169       rs141656213       rs144270222       rs144528676       rs144919513       rs145298267       rs145567521       rs146102143       rs147964178       rs148430937       rs149190925       rs150535225       rs150560538       rs184480918       rs187244346       rs187328838       rs190538500       rs192054471       rs192576424       rs199511352       rs199535360       rs199952147       rs199978374       rs200357256       rs200484550       rs200775717       rs201569992       rs201575800       rs201690043       rs367824810       rs367927175       rs368219197       rs368301064       rs368434699       rs368896812       rs368916106       rs369718297       rs370391649       rs370589917       rs371143827       rs371337506       rs371566075       rs372272086       rs372493481       rs372776370       rs372967666       rs373022378       rs373555075       rs374266192       rs374552636       rs374596572       rs374720373       rs374794406       rs374843947       rs375649462       rs376118851       rs376199765       rs377155232       rs377518535       rs530539546       rs532228591       rs532268505       rs533384772       rs533953002       rs534076461       rs535375895       rs537329821       rs539531896       rs539968311       rs540197639       rs542517981       rs542593709       rs545926743       rs547370037       rs547801821       rs548091306       rs549927441       rs553759903       rs553993036       rs554233627       rs555766403       rs555864858       rs556743952       rs556902486       rs558159287       rs560552597       rs561526866       rs561963016       rs563147216       rs564177893       rs566121005       rs566590193       rs567253400       rs568159078       rs570272361       rs570733235       rs570864488       rs571822377       rs572666276       rs573774183       rs574472476       rs574558339       rs575627526       rs575763582       rs576705069       rs576840899       rs577231020       rs745602766       rs745665338       rs745688535       rs745900042       rs745964067       rs746444196       rs746498360       rs746553570       rs746600156       rs746731643       rs746821662       rs747130034       rs747337123       rs747346787       rs747612402       rs747612893       rs747932237       rs748103723       rs748159277       rs748389805       rs748503066       rs748562532       rs748744537       rs748990425       rs749117362       rs749275816       rs749499390       rs749550609       rs749879940       rs749923717       rs749983173       rs750108134       rs750192413       rs750421541       rs750503509       rs750598232       rs750840590       rs751343867       rs751347442       rs751562455       rs751563770       rs751612151       rs752118697       rs752466790       rs752516418       rs752568845       rs752622869       rs752754919       rs752796425       rs752969980       rs753030151       rs753598467       rs753695186       rs754030966       rs754125809       rs754264359       rs754278750       rs754669790       rs754675974       rs754723203       rs754766104       rs754996883       rs755300759       rs755435458       rs755794964       rs755850738       rs756045411       rs756080187       rs756456741       rs756487511       rs756699620       rs757166459       rs757188444       rs757296757       rs757549746       rs757576212       rs757757759       rs757847965       rs758055703       rs758292335       rs758327426       rs758440313       rs758569167       rs758722123       rs758904136       rs758951243       rs759326080       rs759483789       rs759559145       rs759793550       rs759838849       rs760383919       rs760426566       rs760634954       rs760651462       rs760801858       rs760846944       rs761003596       rs761122849       rs761254291       rs761444400       rs761489645       rs761604673       rs761916489       rs762051946       rs762127922       rs762230765       rs762273449       rs762358886       rs762486976       rs762742835       rs762788193       rs763203093       rs763265227       rs763320214       rs763754105       rs763835643       rs764104832       rs764301892       rs764588779       rs764597143       rs764897922       rs764984049       rs764992575       rs765064396       rs765353024       rs765659265       rs765697359       rs766085789       rs766235194       rs766251435       rs766458317       rs766619320       rs766717064       rs766802694       rs766884358       rs766974749       rs767459514       rs767676207       rs767729722       rs767774772       rs767807598       rs767863601       rs767866230       rs768017191       rs768199769       rs768517023       rs768688752       rs768749801       rs769070292       rs769301332       rs769689160       rs769704625       rs769774030       rs769983147       rs770084656       rs770402190       rs770453390       rs770634971       rs771192558       rs771362731       rs771694538       rs772067351       rs772102415       rs772302526       rs772381266       rs772458605       rs772624105       rs772692994       rs773016894       rs773391949       rs773443212       rs773451042       rs773494755       rs773617801       rs773725798       rs773800827       rs773999193       rs774604004       rs774745924       rs774777448       rs775135464       rs775406928       rs775507446       rs775508204       rs775855784       rs776225088       rs776286858       rs776301420       rs776456968       rs776567106       rs776575942       rs776663113       rs776817835       rs777210047       rs777306978       rs778013849       rs778530805       rs778834190       rs778889139       rs778932071       rs778955025       rs779000159       rs779164653       rs779297514       rs779438762       rs779452478       rs780041342       rs780155085       rs780158910       rs780265548       rs780379208       rs780608359       rs780668780       rs780797184       rs781181338       rs781284020       rs781719144      

基因表达

基因表达

PTGDS基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GAGAAATTCACCGCCTTCTG
59
TCATGCACTTATCGGTTTGG
59
GACGGAACAATAGGACTCC
57
AGAGCAGAGACATCCAGAG
58
GAGAAATTCACCGCCTTCTG
59
CATGCACTTATCGGTTTGGG
60
GAGAAATTCACCGCCTTCTG
59
CATGCACTTATCGGTTTGGG
60
GAGAAATTCACCGCCTTCTG
59
TCATGCACTTATCGGTTTGG
59
CTACTCCGTGTCAGTGGTG
60
TTCTCCTTTAACTCAGCCCT
58
GAGAAATTCACCGCCTTCTG
59
CATGCACTTATCGGTTTGGG
60
CATGTGCAAGTCTGTGGTG
60
TTTCCTGAGGAAGGTGGAG
59
CATGTGCAAGTCTGTGGTG
60
TTTCCTGAGGAAGGTGGAG
59
AGAAATTCACCGCCTTCTG
58
TCATGCACTTATCGGTTTGG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PTGDS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PTGDS基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005215
H0Y5A1(UniProtKB)
IEA
GO:0005576
H0Y5A1(UniProtKB)
IEA
GO:0006629
H0Y5A1(UniProtKB)
IEA
GO:0006810
H0Y5A1(UniProtKB)
IEA
GO:0036094
H0Y5A1(UniProtKB)
IEA
GO:0001516
P41222(UniProtKB)
ISS
GO:0001516
P41222(UniProtKB)
IDA
GO:0004667
P41222(UniProtKB)
ISS
GO:0004667
P41222(UniProtKB)
IDA
GO:0004667
P41222(UniProtKB)
TAS
GO:0005215
P41222(UniProtKB)
ISS
GO:0005501
P41222(UniProtKB)
ISS
GO:0005504
P41222(UniProtKB)
IDA
GO:0005515
P41222(UniProtKB)
IPI
GO:0005576
P41222(UniProtKB)
IDA
GO:0005615
P41222(UniProtKB)
IDA
GO:0005789
P41222(UniProtKB)
TAS
GO:0005791
P41222(UniProtKB)
IDA
GO:0005794
P41222(UniProtKB)
ISS
GO:0006810
P41222(UniProtKB)
ISS
GO:0019371
P41222(UniProtKB)
TAS
GO:0031965
P41222(UniProtKB)
IEA
GO:0045187
P41222(UniProtKB)
ISS
GO:0048471
P41222(UniProtKB)
IEA
GO:0051384
P41222(UniProtKB)
IEA
GO:0070062
P41222(UniProtKB)
IDA
GO:0070062
P41222(UniProtKB)
IDA
GO:2000255
P41222(UniProtKB)
IEA
GO:0005215
Q5SQ11(UniProtKB)
IEA
GO:0006629
Q5SQ11(UniProtKB)
IEA
GO:0006810
Q5SQ11(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PTGDS基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Sensorineural Hearing Loss (disorder) 0.080271442 2 0 BeFree_RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.08 1 0 RGD
Pendred's syndrome 0.006786047 25 0 BeFree
Alzheimer's Disease 0.005991584 4 0 BeFree_LHGDN
Asthma 0.004267125 8 0 BeFree_GAD
Atherosclerosis 0.003267234 3 0 BeFree_LHGDN
AIDS Dementia Complex 0.00272435 1 0 LHGDN
Schizophrenia 0.00272435 1 0 LHGDN
Malignant neoplasm of breast 0.002638474 1 0 BeFree_GAD
Carotid Atherosclerosis 0.002638474 1 0 BeFree_GAD
Immediate hypersensitivity 0.002367032 1 0 GAD
Kidney Failure, Chronic 0.002367032 1 0 GAD
Periodontitis 0.002367032 1 0 GAD
Bronchial Hyperreactivity 0.002367032 1 0 GAD
Hearing Loss, Mixed Conductive-Sensorineural 0.001628651 6 0 BeFree
Enlarged Vestibular Aqueduct 0.001357209 5 0 BeFree
Dehydration 0.001085767 4 0 BeFree
Goiter 0.001085767 4 0 BeFree
Pneumonia 0.001085767 4 0 BeFree
Flushing 0.000814326 3 0 BeFree
Allergic asthma 0.000814326 3 0 BeFree
Congenital ear anomaly NOS (disorder) 0.000814326 3 0 BeFree
Nonsyndromic Deafness 0.000814326 3 0 BeFree
Adenoma 0.000542884 2 0 BeFree
Arteriosclerosis 0.000542884 2 0 BeFree
Bipolar Disorder 0.000542884 2 0 BeFree
Brain Neoplasms 0.000542884 2 0 BeFree
Colitis 0.000542884 2 0 BeFree
Ulcerative Colitis 0.000542884 2 0 BeFree
Craniosynostosis 0.000542884 2 0 BeFree
Eosinophilia, Tropical 0.000542884 2 0 BeFree
melanoma 0.000542884 2 0 BeFree
Nasal Polyps 0.000542884 2 0 BeFree
Degenerative polyarthritis 0.000542884 2 0 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Thyroid Diseases 0.000542884 2 0 BeFree
Polyendocrinopathies, Autoimmune 0.000542884 2 0 BeFree
Chronic sinusitis 0.000542884 2 0 BeFree
Autoimmune thyroid disease 0.000542884 2 0 BeFree
Dyslipidemias 0.000542884 2 0 BeFree
Manic 0.000542884 2 0 BeFree
Thyroid carcinoma 0.000542884 2 0 BeFree
Astrocytoma 0.000271442 1 0 BeFree
Malignant tumor of colon 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Cryptorchidism 0.000271442 1 0 BeFree
Dermatitis 0.000271442 1 0 BeFree
Dermatitis, Atopic 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Dry Eye Syndromes 0.000271442 1 0 BeFree
Patent ductus arteriosus 0.000271442 1 0 BeFree
Dyspepsia 0.000271442 1 0 BeFree
Eczema 0.000271442 1 0 BeFree
Exanthema 0.000271442 1 0 BeFree
Gastritis 0.000271442 1 0 BeFree
Glioblastoma 0.000271442 1 0 BeFree
Graves Disease 0.000271442 1 0 BeFree
Guillain-Barre Syndrome 0.000271442 1 0 BeFree
Hyperinsulinism 0.000271442 1 0 BeFree
Intestinal Neoplasms 0.000271442 1 0 BeFree
Keratoconus 0.000271442 1 4 BeFree
Lymphoma 0.000271442 1 0 BeFree
Medulloblastoma 0.000271442 1 0 BeFree
Meningioma 0.000271442 1 0 BeFree
Neurofibromatosis 2 0.000271442 1 0 BeFree
Obesity 0.000271442 1 0 BeFree
polyps 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Sinusitis 0.000271442 1 0 BeFree
Thyroid Neoplasm 0.000271442 1 0 BeFree
Renal fibrosis 0.000271442 1 0 BeFree
Congenital heart disease 0.000271442 1 0 BeFree
childhood brain tumor 0.000271442 1 0 BeFree
Papillary thyroid carcinoma 0.000271442 1 0 BeFree
Medulloblastoma, Childhood 0.000271442 1 0 BeFree
Dryness of eye 0.000271442 1 0 BeFree
Senile Plaques 0.000271442 1 0 BeFree
Anaplastic astrocytoma 0.000271442 1 0 BeFree
Aspirin-sensitive asthma with nasal polyps 0.000271442 1 0 BeFree
Medulloblastoma of cerebellum 0.000271442 1 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Unilateral Cryptorchidism 0.000271442 1 0 BeFree
Metabolic Syndrome X 0.000271442 1 0 BeFree
Preauricular Fistulae, Congenital 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Hashimoto Disease 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Spots on skin 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree
Malignant neoplasm of ovary 0.000271442 1 0 BeFree
Attention deficit hyperactivity disorder 0.000271442 1 0 BeFree
Astrocytoma, low grade 0.000271442 1 0 BeFree
Mammary Neoplasms 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Chronic Kidney Diseases 0.000271442 1 0 BeFree
Meningioma, benign, no ICD-O subtype 0.000271442 1 0 BeFree
Acute inflammatory demyelinating polyneuropathy 0.000271442 1 0 BeFree

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